• 🇳🇿 🇲🇲 🇯🇵 🇨🇳 🇦🇺 🇦🇶 🇮🇳
    Australian & Asian
    Drug Discussion

    Welcome Guest!
    Posting Rules Bluelight Rules
  • AADD Moderators: andyturbo

Selegiline (l-deprenyl) - too good to be true?

The experiment has begun! 5mg saturday, 5mg sunday, 5mg today.

I tried having 500mg DL-Phenylalanine on an empty stomach and definitely felt more awake, esp since I was up late last night and felt tired this morning... Hard to say whether there was significant mood lift.

Will keep an update of the situation...
 
The soviets (and the Americans probebly) used sensory ilsolation for interigation during the cold war, sent people up the wall....except there wasn't one :)
 
I have to say my experience with selegiline has been mediocre at best.

Initially I felt a mild stimulant effect, but that subsided within a day or two.

After a week at 5mg some days / 10mg other days I assumed i would have reached near total MAO-B inhibition.

500mg of DL-Phenylalanine made me feel a little more alert, though nothing significant.
1000mg of DL-Phenylalanine woke me up a bit more, but still only really comparable to about 50mg caffeine. No real mood lift in either case.

My head doesn't really feel any clearer now, nor my memory better...

I was mostly interested in selegiline for a nootropic/stimulant effects, but both seem to be quite minimal in my case.

Additionally: Had like 3 glasses of wine last night and felt rediculously tired.

I'm wondering whether perhaps I haven't given it long enough, or whether some other factor comes into play, but on the whole I'm extremely disappointed. :(
 
Damnit! So you cant read my thoughts? Are we sure? Im thinking really hard of a number between 1 and 10.
 
Interesting... as Nanobrain said in one of his posts that the effects are noticeable almost immediately. Its probably because you're trying to hard to notice the effects that you want to feel (maybe?). Anyway, I also have some on the way, hopefully arriving this week, so I will let you know if I have sismilar results. Also will be potentiating with L-Phenylalanine. Just on that note, you mentioned that you used DL not L-Phenylalanine........maybe that was the problem?
 
DLPA is 50% L-Phenylalanine anyway, I can hardly see the problem.

I have a long-term experience with depression.

I found selegiline + DLPA to be of no benefit for that either.
 
Damn thats disappointing.

Will you be combining with mdma at all?

Im interested in this as a secondary curiosity only. All the literature seems inconclusive and if I do try this it will be with a half only (somewhat nervously I might add).

EDIT: just your recent semi-trip report in ecstacy discussion where you again describe disappointing effects. Its strange that there are so many contradictory reports out there. (Ive read reports on a different board that describe the experience to be more on the positive side.....also Nano's).
 
Last edited:
Re that discussion in ED, I have a feeling its because I'd taken 5mg the day before... possible dopamine receptor downregulation?

At the same time it's quite possible to attribute it to the fact that I've got a semi-high tolerance at the moment.... really hard to say.

I may try the combination with MDMA again in the future, when my neurochemical slate is a little cleaner :p, but if that proves fruitless then no.
 
^DLPA is crap, does not work, i reckon the dextro cancels out the action of the levo ;-)

seriously. 1,500 mg LDPA has zero effects on me, wheras 500 mg of LPA produces a definite mood lift.

as for Deprenyl, thankfully, you will probably never get to total MAO-B inhibition with standard dosing. its a good thing, Chairman MAO's activities are not limited to metabolising fun drugs.

remember, the action of l-dep is cumulative, wait for ~4 weeks before pronouncing final judgement.

did i mention DLPA is crap?
 
does 5 mg every other day have a noticeable effect?

[Edit: sourcing question removed. BT]
 
Last edited by a moderator:
Hey,
I just purchased l-phenylalanine online no probs. From NZ...
 
Last edited by a moderator:
no probs getting it into here? customs sticker and all?

nanobrain - in your opinion, how long after you cease administration does it take to return to baseline... esp after taking it for a long time?

I'm extremely concerned about the interaction between selegiline and MDMA after chronic dosing... not just in terms of the absence of a high, which many report, but in terms of safety.

nanobrain - i see your brand is Musashi. Did you have any problems ordering it into the country?
 
Just received 'Xcel Health' brand L-P today with my 5-htp. Took no less than 5 days to arrive. Nice.
 
LPA is available freely in Australia - it is a nutritional supplement after all, you dont have to go online.

Musashi powder is available at many health/nutrition stores, although i prefer the 500 mg LPA caps

here's how to increase bioavailability and synergism of both substances: take the LPA w/your morning coffeee if you are a coffee drinker, on an empty stomach. take the l-dep shortly after you have a bit of brekkie (l-dep bioavailability is increased 3-4-fold w/food).

takes about 2-4 weeks to return to baseline MAO levels after a course.

VelocideX, combining MDMA and l-dep is always risky from a safety standpoint given individual sensitivity and metabolic differences. while i haven't heard of any adverse reactions besides the ones mentioned by Murple awhile back and have not personally had any trouble, i would still be cautious even though it does not sound like your dosing regimen / cumulation levels are a cause for concern.

it would be sensible, to start out by cutting the MDMA dose to 1/2 standard (although this may lead to the absense of a high you spoke of).
 
Last edited by a moderator:
Guys, there's only 2 exceptions to the no sources rule - 5-HTP and EZ-test.

BigTrancer :)
 
Last edited:
eep. sorry :(
kinda presumed it was ok considering its legal. apologies again.
 
the DLPA gave me huge amounts of energy to the point of hyperactivity...maybe verging on some euphoria...and then a couple of hours later i couldnt keep my eyes open. i was falling asleep in class and at home i had to take afternoon naps of several hours..
given uni and masses of assessments, i couldnt keep the whole thing going long enough to see if this improved any...
 
I've only briefly browsed this thread, so forgive any misconcpetions I have. Here's my input:

1. Serotonin syndrome is chiefly dangerous becuase of serotonin's role in thermoregulation, most importantly core temperature. A person may feel cool to the touch but have a very high core temperature. Rhabdomyolysis (and subsequent death) is generally the worst case scenario in both serotonin syndrome and heatstroke. This is no conincidence...

2. Deprenyl should not be used by people who cannot explain how it works, every possible drug interaction and carry a card in their wallet stating: "WARNING: TAKING MAOI, DO NOT ADMINISTER ANY SYNTHETIC OPIATES/OPIOIDS (Demerol, Fentanyl, etc). USE MORPHINE ONLY!"

3. Aromatic amino acids (phenylalanine, tyrosine, tryptophan) need to be taken with copious amounts of vitamin B6 (5:1 amino acid/B6 ratio) and need to be taken on a completely empty stomach (at least 3 hours fasting) followed by another 60-90 minutes of fasting.

4. Deprenyl has ZERO, Z-E-R-O, Z-E-R-O recreational potential. It is not euphoric itself and does not potentiate the euphoric effects of any drugs, if anything (in my experience) it greatly diminishes them. The possible exception is MDMA. It does not potentiate MDMA, but not does it diminish euphoria.

5. Is anyone capable of posting references on this website???


X
 
You must log in or register to reply here.
Top