N&PD Moderators: Skorpio
You should upgrade or use an alternative browser.๐๐ Social ๐๐ Rectify's molecular poetry thread
Smyth2
Bluelighter
This is Nikethamide.
TEPID_PEPPERMINT_WUNDERLANDE
1-(3-pyridinyl)-N,N-diethylaminomethanone
Possible Nicotine Alternative.
Is It Carcinogenic?
Probably, But So Are 60% Of The Psych Meds Out There.
Amphetamine Is Not Carcinogenic, However.
Also see Arecoline-Nikethamide (THPC) [26070-52-0]
1-Methyl-1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide)
pubchem.ncbi.nlm.nih.gov
[2] Smythies JR, Beaton J, Benington F, Morin RD. Behavioural effects of some derivatives of amphetamine and LSD and their significance. Nature. 1970 May 16;226(5246):644-5. doi: 10.1038/226644a0. PMID: 5444927.
[3] Smythies JR, Beaton JM, Benington F, Morin RD. The design of some new compounds to block psychotomimetic drugs. Eur J Pharmacol. 1972 Feb;17(2):270-2. doi: 10.1016/0014-2999(72)90168-9. PMID: 5026401.Smyth2
Bluelighter
Have you seen Trimetazidine. This is the closest match to it that I know of.
MEZCAL
1-(3,4,5-trimethoxyphenyl)-piperazine
Possible Antidepressant.
Smyth2
Bluelighter
I have seen an antibiotic before with tranylcypromine in the structure.
ANTISNUFFLEUFUGUS
(2S,5R,6R)-2-carbomethoxy-6-[2-(3,4-methylenedioxyphenyl)-1-methylethylamino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane
It was by Lednicer's colleague Lester Mitscher but he is dead now also.
6-Fppcoqc
[103531-48-2]Smyth2
Bluelighter
This reminded me of 5,6-Dibromotryptamine, which you have probably seen already.
CAPITAN BRO MO 'RUSTY' RIKER
1-(3,4-dibromophenyl)-2-methylaminopropane
Would I Take That? Sure, Why Not?
Another structure that showed up in my database was PC44156003.
[1] Shao, Liming; Li, Wei; Xie, Qiong; Yin, Hong (2013). "Triple reuptake inhibitors: a patent review (2006 โ 2012)". Expert Opinion on Therapeutic Patents. 24 (2): 131โ154. doi:10.1517/13543776.2014.859676.
[2] Dan Peters, John Paul Redrobe, Elsebet รstergaard NIELSEN, WO2009090173 (2009 to Neurosearch A/S).
Dibromo is stronger than for dichloro in the IC50 value which was 4nM for DA, 3.1nM for NE & 120nM for 5HT.
Another place that reminds me of 2 bromine halogens replacing 2 chlorines is for Brombuterol.Smyth2
Bluelighter
or LEK-8841 [145204-80-4]
or Brazergoline [60019-20-7]
or Bromerguride
or Bromocriptine