• 🇬🇧󠁿 🇸🇪 🇿🇦 🇮🇪 🇬🇭 🇩🇪 🇪🇺
    European & African
    Drug Discussion

    Welcome Guest!
    Posting Rules Bluelight Rules
  • EADD Moderators: Shambles

Professor Nutt's magic jizz (Sentia)

Ismene2 said:
I think saying Sentia will get you high is like saying my arse is a soft ice-cream machine. Sure I could fill a cone for you but anyone with half a brain knows its not the same.
Click to expand...
WHAT a metaphor...

I'd like to steal it and use it but... tubs only here. BIG tubs... Otherwise all there will be is lots of broken wafer everywhere and crying children (and adults too possibly).
 
4DQSAR said:
It is a 'freebase' or, rather I should say it contains neither a free carboxylic acid nor a basic nitrogen (at least at physiolgical pH) so while yes, you certainly can nebulize the ligand... that would just add risk with no real benefit.

We sort of assumed it would be presented in a similar way to alcoholic drinks i.e. the dilution means taking too much becomes practically much harder. I would start low. Maybe if an 'ethanol equivelence' can be found, shart with drinks that are no more potent that regular lager/beer as very few people come to harm if they stick to weaker forms.

Something pure where 40mg will result in the user ending up fast asleep (but won't vomit so there's a mercy) is probably not a good thing.

We did have several cohor members who INSISTED that 30mg 'wasn't enough' but add 10mg and all of them just fell asleep.

But tranche 2 also demostrates a plateau in it's effects. To be sure it's still going to equate to pretty damned wasted but eat more and duration increases, not subjective effects. One person took 80mg and slept for 24 hours - but was fine. No toxic symptoms.
Click to expand...
Wow. Thanks.

While the addition of the further 10mg may seem useless I'd like to point out that a small number of drinkers drink with oblivion being the end goal. If tranche 2 offers this without the risk of vomitting whilst unconscious and the associated hepatotoxicity then there is a legitimate use in terms of harm reduction. However, any idea what the effects of regular consumption (1-2 times a week) at this level would do to receptor expression and internalisation?

BB
 
I still can't believe this sentia is selling so well. Its total shit. If the money is going towards alcarelle then im ok with it but if its just an ongoing thing with a tiny effect then im not.

Looking like Nutt's best work is behind him.
 
Shill time...well kinda

Got this from a June article.

GABA is a neurotransmitter that blocks signals between nerve cells, producing a feeling of sedation and relaxation. When you consume traditional alcohol, it binds to GABA receptors and mimics their effect. However, alcohol also overstimulates other neurotransmitters, causing side effects such as impaired thinking and movement, hangovers, and liver damage.

Alcarelle specifically targets GABA receptors, allowing the release of dopamine and serotonin without activating the pathways that produce negative effects. According to Nutt, the molecule is approximately 100 times safer than traditional alcohol. A consumer only needs micrograms of Alcarelle to achieve the same effect as the grams of alcohol in a conventional drink.

The exact chemical composition remains a trade secret protected by the company.
 
Update..gaba labs secured funding of about £525,800 in 2026 for the real jiz.


Pea nutts
 
new2drugs said:
Alcarelle specifically targets GABA receptors, allowing the release of dopamine and serotonin without activating the pathways that produce negative effects. According to Nutt, the molecule is approximately 100 times safer than traditional alcohol. A consumer only needs micrograms of Alcarelle to achieve the same effect as the grams of alcohol in a conventional drink.
Click to expand...

This just sounds like GHB but more potent. I don't see him creating a drug that hits the GABA receptors sufficiently but is somehow non-addictive unlike literally every other GABA drug. We've already tried this with heroin as a substitute to morphine and it did not achieve it's goals.
 
Ismene2 said:
Ghb was the only drug ive ever felt was dangerous - the dose between feeling a bit drunk and being collapsing unconscious for 3 hours was tiny. God knows what Dr Nutt did with my ringpeice during that lost period.
Click to expand...


Here he is trying it years ago
 
Ismene2 said:
Ghb was the only drug ive ever felt was dangerous - the dose between feeling a bit drunk and being collapsing unconscious for 3 hours was tiny. God knows what Dr Nutt did with my ringpeice during that lost period.
Click to expand...
Yeah, for safety the doses need to measured accurately with 2ml oral syringes, and also, if discipline can be maintained, as things get more and more chaotic, then making a note of dosage times., so you don't dose too often is sensible.. In practice that can easily fail to happen, ime, but the second best, is -re-dosing when you feel the earlier dose wearing off.

I think 1.2 - 1.4ml is a fairly standard dose range, for a decent strong dose. IIRC.

And I think finding your good dose. and sticking to it, is key to being able to enjoy GBL safely. That is way more important than waiting exact times before re-dosing, as long as your not doing that way too quickly.

IIRC at least an hour should be allowed before re-dosing, ideally more, but individuals speed of metabolising this drug can vary, as well as tolerance, so it's not really possible to give an exact re-dose time that would be right for everyome.
 
Update on the gaba labs website...they've pulled the 2028 target...oh dear. So that's probably never going to happen now.

Think its time to give up hope
 
new2drugs said:
Alcarelle specifically targets GABA receptors, allowing the release of dopamine and serotonin without activating the pathways that produce negative effects. According to Nutt, the molecule is approximately 100 times safer than traditional alcohol. A consumer only needs micrograms of Alcarelle to achieve the same effect as the grams of alcohol in a conventional drink.
Click to expand...
This must have some relatively complex mode of action then?

Because although my knowledge of brain chemistry and how substances affect this is pretty much just a basic grasp of the essential fundamentals, and I'm not going to pretend to know much more than that, but as far as I understand things, gabaergic substances like benzos boost gaba, (obviously,) and substances that act on dopamine, such as the ADHD stimulants for example, boost levels of dopamine (again self-evidently obviously). And things like Ecstasy release floods of serotonin into your brain, as everyone who knows the first thing about Es knows.

I am aware of some substances that act on more than one neurotransmitter, eg mephedrone hits dopamine and serotonin, and I think cannabis activates dopamine as well as the cannabinoid receptors. I'd have to give myself a refresher course on all of this, (and also a more in depth understanding would certainly be beneficial,) to be confident in any further statements. But I believe that alcohol acts on gaba and dopamine (for some - I don't think I get any noticeable increase in dopamine from it) and it seems Alcarelle is trying to mimic alcohol's modes of action by trying to act on various multiple neuro transmitters - gaba, dopamine, and serotonin - all from one subtance.

It seems pretty ambitious and unusual to me, but as I've said this is not a subject I know a great deal about, although I am interested. I suspect Alcarelle is only going to lightly tickle those 3 receptors, at best. I mean, if it had powerful effects on all 3 receptors / neurotransmitters it would be one of the best substances ever invented. And I doubt it is that.

I still don't even understand how he can invent a substance that is supposedly psycho-active, when all such old and new substances were blanket banned in the UK under the NPS Act of 2016, or whenever it was.

If it is actually psychoactive then it must be banned, and if it isn't, then it's totally useless?
 
Last edited:
Bleaney said:
This must have some relatively complex mode of action then?

Because although my knowledge of brain chemistry and how substances affect this is pretty much just a basic grasp of the essential fundamentals, and I'm not going to pretend to know much more than that, but as far as I understand things, gabaergic substances like benzos boost gaba, (obviously,) and substances that act on dopamine, such as the ADHD stimulants for example, boost levels of dopamine (again self-evidently obviously). And things like Ecstasy release floods of serotonin into your brain, as everyone who knows the first thing about Es knows.

I am aware of some substances that act on more than one neurotransmitter, eg mephedrone hits dopamine and serotonin, and I think cannabis activates dopamine as well as the cannabinoid receptors. I'd have to give myself a refresher course on all of this, (and also a more in depth understanding would certainly be beneficial,) to be confident in any further statements. But I believe that alcohol acts on gaba and dopamine (for some - I don't think I get any noticeable increase in dopamine from it) and it seems Alcarelle is trying to mimic alcohol's modes of action by trying to act on various multiple neuro transmitters - gaba, dopamine, and serotonin - all from one subtance.

It seems pretty ambitious and unusual to me, but as I've said this is not a subject I know a great deal about, although I am interested. I suspect Alcarelle is only going to lightly tickle those 3 receptors, at best. I mean, if it had powerful effects on all 3 receptors / neurotransmitters it would be one of the best substances ever invented. And I doubt it is that.

I still don't even understand how he can invent a substance that is supposedly psycho-active, when all such old and new substances were blanket banned in the UK under the NPS Act of 2016, or whenever it was.

If it is actually psychoactive then it must be banned, and if it isn't, then it's totally useless?
Click to expand...
I think of it this way in layman's terms.

.Alcohol is a SMALL molecule so it gets everywhere in the brain, but starts with gaba.

.This new thing will be a LARGE molecule and only affects gaba cause it doesn't fit anywhere else no matter how much of it there is.
 
Bleaney said:
This must have some relatively complex mode of action then?

Because although my knowledge of brain chemistry and how substances affect this is pretty much just a basic grasp of the essential fundamentals, and I'm not going to pretend to know much more than that, but as far as I understand things, gabaergic substances like benzos boost gaba, (obviously,) and substances that act on dopamine, such as the ADHD stimulants for example, boost levels of dopamine (again self-evidently obviously). And things like Ecstasy release floods of serotonin into your brain, as everyone who knows the first thing about Es knows.

I am aware of some substances that act on more than one neurotransmitter, eg mephedrone hits dopamine and serotonin, and I think cannabis activates dopamine as well as the cannabinoid receptors. I'd have to give myself a refresher course on all of this, (and also a more in depth understanding would certainly be beneficial,) to be confident in any further statements. But I believe that alcohol acts on gaba and dopamine (for some - I don't think I get any noticeable increase in dopamine from it) and it seems Alcarelle is trying to mimic alcohol's modes of action by trying to act on various multiple neuro transmitters - gaba, dopamine, and serotonin - all from one subtance.

It seems pretty ambitious and unusual to me, but as I've said this is not a subject I know a great deal about, although I am interested. I suspect Alcarelle is only going to lightly tickle those 3 receptors, at best. I mean, if it had powerful effects on all 3 receptors / neurotransmitters it would be one of the best substances ever invented. And I doubt it is that.

I still don't even understand how he can invent a substance that is supposedly psycho-active, when all such old and new substances were blanket banned in the UK under the NPS Act of 2016, or whenever it was.

If it is actually psychoactive then it must be banned, and if it isn't, then it's totally useless?
Click to expand...
Trying to make it as a food additive rather than a substance. and also getting it granted on the American GRAS thing ..

generally regarded as safe.
 
You must log in or register to reply here.
Top