Well. I can fathom this. Fact is, we don't know the binding affinity of the molecule, or how much of what is taken actually binds to an opioid receptor. Maybe only a small percentage.
I went from snorting 5 mg opana to rectal dosing of 4 40mg tablets/day, and the bioavailability of rectal administration of opana is almost ten times as high. So, let's call it 6 times bioavailability, just to stay conservative. 6 x 160 = 960mg opana /day, which is equal to roughly 2000mg oxy/day. While this is purely conjecture, it is educated congecture, and somewhat supported by the fact that at one point I could take three OC80s at once, chewed, to get off for two hours. This was a completely new experience for me, and when I ran out of everything the WDs started within 3 hours, and intensified greatly by the minute. They were unbearable at the 24hour mark. I went to the hospital and waited two hours just to get a lecture and a clonodine - no narcotics were given for WDs where I went. Long story short, the hard physical part lasted roughly two weeks, followed by a week of total confusion and weakness. About midway into the fourth week I obtained some suboxone. It took 24mg to make me feel normal. I had five pills only, and I took the last two the next day. I was worried that it would throw me back into withdrawals when it wore off, but I just kind of felt sluggih for a few days after it wore off, and one week after that I felt pretty normal. So I thought it might be fun to take a bit of oxy one night, so, assuming my tolerance was back down I took one OC80 and felt nothing. Followed it with three OC40s and got a pretty good buzz that ;lasted about two hours. No withdrawals. Anyway, I just wanted to point out how easy a tolerance can grow to unbelievable dimensions if you are taking a powerful opioid all day, every day.
