• N&PD Moderators: Skorpio

New Drugs in the future???

And probably as such, a 5HT2b agonist, which was the reasonm fenfluramine was withdrawn (caused pulmonary hypertension).

Someone else can be the guinea pig for that drug!

Lol, good thing I'm not part of that scene I guess. I'm curious if you feel that 3-fluoroethamphetamine is potentially the most dangerous of the potentially recreational 2,3,4 fluorinated amphetamines with and without N-alkyl groups, because it is the most similar to fenfluramine or if you're equally concerned by the others like 4-FA and 4-FMA or 4-FEA. I'm probably wrong but I was under the impression that in this respect the para-fluoroamphetamines had more potential for risk since at least according to the experience reports they're often used at the high doses necessary to bring entactogenic qualities and these high doses also appear to carry strong appetite suppression as a side effect. The meta and ortho fluorinated amphetamines appear to be used in lower doses and seem to be more strictly stimulants which would imply less general 5-ht affinity, although of course this doesn't say much about 5-ht2b affinity. I suppose the damage from 5-ht2b agonism can take a long time before it is apparent and just because there's no reports of these problems yet with 4-FA doesn't mean that 3-FA and it's N-substituted relatives are not risky even if they are less dangerous than 4-FA.
 
i wish they would invent an antidepressant that actually works.

Tianeptine, Amineptines little brother. My suggestion is to sudy that class a bit more to find a drug that has pleasant and mood-lifting properties with a great therapeutic range and little addiction potential.
 
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Ah you Brit's have the most cool humour!

New drugs in the future? I still hope something stems from these Glutamate-antagonists which will be, finally, accepted by a broad audience.
 
More like Ibogaine.

remember seeing a tv program about ayahuasca and ibogaine both as methods for curing addiction. also about how Francis Crick deduced the double-helix structure of DNA whilst taking lsd.=D
 
I was one of the victims of the AMT/5-MeO-AMT mishap. Once it was emergency scheduled, I obtained some from a vendor overseas and trusted that it was actually AMT. Took 60mg, my normal AMT dose, and I knew something was wrong when in about 15 minutes later I got super sick, everything started spinning, then the heart palpitations started and my heart rate quickly increased... I was at a house party and I (stupidly) made the decision to drive home - the patterns were more intense than DMT - much more intricate and quite "real" in the sense that they were interactive... Anyway. I ended up calling the ambulance when the chest pains started.

Pulse was 225, BP 190/95. Got to the hospital and told them what I took, they looked it up online, I heard some discussion about how its just going to keep stimulating me until my body gives up and they pumped me full of ativan. After four IV Ativan doses, my body calmed down. They released me 6 hours later and I continued to feel the immense body load of 5-MeO-AMT for two more days with transient hallucinations for another 18 hours and auditory hallucinations for about 20 hours. I don't know how I didn't die that night - and neither does the hospital.

I have not touched research chemicals since - other than M1 - and I don't plan to either. I personally think that these companies (both that do the synth and do the selling) are purely in it for the money and really don't give a damn about anything else, including making sure they are getting the right product out, that the product is pure, etc. Thanks but no thanks.

Well duhh... Name one drug dealer or even a legit chemical company the ISN'T in it for the money. Sorry to hear about yer episode(that's y I always carry benzos whenever I trip). Drugs are dangerous, the same shit u described happens on the street aswell all the time, especially with opiates and Epills. It's because its such a grey market thing. If these vendors wanted to spend all the extra cash to make their company legit and then provide private individuals like us with easy access to the drugs we seek then they are just asking to get shutdown, sued, jailed... Unfortunatly cuz of the laws the way they are there just can't b any regulation. All the companies I knew of that sold these things for decent prices that were legit are now regretting it. It sux but that's the way govs make it
 
remember seeing a tv program about ayahuasca and ibogaine both as methods for curing addiction. also about how Francis Crick deduced the double-helix structure of DNA whilst taking lsd.=D

francis crick stole the X-ray crystallography evidence of the double helix from rosalind franklin.

i think your misremembering the story of kary mullis who thought of PCR while tripping acid
 
back-to-the-future-delorean.jpg



quick let's push it to 88 and totally step on shulgins toes
 
A bit further in the future; electronic drugs, devices that electrically activate receptors. Technology exists.

Just how do you see this working? Because I sure as hell don't! Anyways

How about some peptides for drugs of the future?

Same targets, new tricks.
 
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francis crick stole the X-ray crystallography evidence of the double helix from rosalind franklin.

i think your misremembering the story of kary mullis who thought of PCR while tripping acid

no it was definitely crick who was interviewed on the program - i remember taping it and watching it a few times - had loads of famous acid heads talking about stuff. don't know as to his claims of being the first to visualise the double-helix structure though... maybe he took lsd and then convinced himself he had discovered it but was just tripping balls at the time. =D

http://www.mayanmajix.com/art1699.html
 
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