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New Drugs in the future???

also things like escaline & proscaline have rather high dosages & thus lower profit margins. Also, from what i recall in pihkal they weren't terribly interesting.
 
^I think these were just some examples to demonstrate that there is still plenty to commercialize from TIHKAL & PIHKAL. The vast majority (if not all) of Shulgin's children is now directly forbidden resp. by analogue laws. Sad enough! This man has done some really good work. But it's not just him. Nichols, Glennon, etc etc...

Still I don't see a point in suggesting the next RC. I know, the OP asked which one might come next; nonetheless is every guess as good as a suggestion. If you can't make up your own mind or are too lazy to do some literature research (no offense intended!), well, that's simply bad luck.
There are a couple of very intelligent and creative people at work, trying to find (and test) novel psychoactive substances, but as soon as they mention their findings in a forum, it gets instantly exploited by some faggot vendors. Only short time later we see irresponsible fools overdose, fatalities happen and the stuff is on the prohibition lists. It happened so many times, and with absolute certainty it will happen again.

Therefore, I disagree with Phener in this case: I prefer not to discuss such stuff in public anymore. I don't give a damn for half-baked dummies*, only greedy for the next quick high, preferably commercially available with fancy names a lá "Benzo Motherfuck". I had a different opinion not too long ago :\


Back on topic, I still agree that the next RCs to come are probably some of the NBOMe-family. They are no secret anymore.
I'd also think that some AAI-derived cannabinoids will be seen; some, which do not fit into the phrasing of the current analogue laws. The majority of the THC-derived cannabinoids have a too complex stereochemistry and are too expensive for marketing though.
Opioids are rather unlikely but not impossible. Desmethyltramadol was sold (maybe it still is), first fentanyls were spotted, too.


Peace! - Murphy


* Don't get me wrong: I'm not aiming at anybody in particular with this term, e.g. Phener. It's just my frustration that you see here.
 
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MurphyClox said:
There are a couple of very intelligent and creative people at work, trying to find (and test) novel psychoactive substances, but as soon as they mention their findings in a forum, it gets instantly exploited by some faggot vendors. Only short time later we see irresponsible fools overdose, fatalities happen and the stuff is on the prohibition lists. It happened so many times, and with absolute certainty it will happen again.

Therefore, I disagree with Phener in this case: I prefer not to discuss such stuff in public anymore. I don't give a damn for half-baked dummies*, only greedy for the next quick high, preferably commercially available with fancy names a lá "Benzo Motherfuck". I had a different opinion not too long ago

Back on topic, I still agree that the next RCs to come are probably some of the NBOMe-family. They are no secret anymore.
I'd also think that some AAI-derived cannabinoids will be seen; some, which do not fit into the phrasing of the current analogue laws. The majority of the THC-derived cannabinoids have a too complex stereochemistry and are too expensive for marketing though.
Opioids are rather unlikely but not impossible. Desmethyltramadol was sold (maybe it still is), first fentanyls were spotted, too.
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I feel and share your anger but feel uncertain as to what exactly you are suggesting. Do we all keep quiet until HIT with the next wave of drug - then thank god we can discuss it?! I.e is it now safe for us to talk about NBOMe-family drugs?

* Don't get me wrong: I'm not aiming at anybody in particular with this term, e.g. Phener. It's just my frustration that you see here.
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Lashing out at people discussing anything remotely novel is not going to magically resolve the meph-madness hangover from hell.
 
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RC = Research chemical (that question absolutely on topic, btw ;) )

@Phener: Well, I know that I'm a minority with my thinking and most others consider my attitude as snobbish and downright arrogant, but reality seems to confirm it. As an example, there was a recent thread where somebody asked about (I cite) "amthetamine & methamthetamine", which seem to have reached the market recently. These compounds (being the thiophene-analogues of plain (meth)amphetamine) were actually discussed beforehand on another forum, too, but that makes no difference. (I just checked Bluelights ADD and found discussion that is even older)

I personally even claim the right to have invented these two names. Don't get me wrong: Not the compounds, just the names, which were derived with the same logic as once the term 'alpha-methyl phenethylamine' (the correct spelling for the bioisosters would be 'amthienetamine' though).

Anyway, the name is of no importance. What is important that these compounds were actually discussed beforehand, including unambiguous statesments like:
this one with 2-thienyl would have strong vasoconstrictor properties, i remember someone assayed it on xxxxxxxx.xxxx and said that stimulation was better than amphetamine but those damn vasoconstrictor properties are bad.
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Please, be careful with thiophenes, especially if dosages are high or if repeated use is expected. The thiophene ring can be metabolized to its S-oxide, sulfone or S-chloride. All of them are electrophilic, which may result in toxicity.
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more peripheral actions than amph (reported tactile feelings in the extremities)
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The compound was assayed but there were reports of negative peripheral activity in comparison to amphetamine. Something about a weird hideous smell if I remember right, but I may not.
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...and more. Search Bluelight and you'll find these statements confirmed by FnB & Nuke.

NONETHELESS did they hit the market! Personally, I was still in the phase of aquiring precursors and scheduling a synthesis plan - but these compounds are most probably banned before I can say 'WTF'.

The same story with BTCP!!! :(

Therefore, you wont see any more new suggestions from me. I may confirm what was already revealed, but for sure I wont name compounds just to increase some idiot's salary.


- Murphy



P.S. I cited the details with the naming just to show that I'm well aware that discussions in which I took part were used as inspiration for 'novel RCs'. That's all. Even if my invention was not used for the naming, the chronological coincidence of the discussion about these compounds and their appearance on the market could be seen by 5-year-old, blind retard.
 
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ok :) Appologies - I do now at least understand your logic and even more so your anger.

The old buzzed up days of just reading peoples plans and experiments was absolutely golden. Totally did it for me. If now bluelight itself is slowing down - *sigh* bad times
 
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it's time like this when I wish I was in a place where I could talk to people about such things and keep it local. :( The internet used to be my escape from not being able to talk about such things with anyone I know!

possibly time to get back in to research:\
 
Phener said:
it's time like this when I wish I was in a place where I could talk to people about such things and keep it local. :( The internet used to be my escape from not being able to talk about such things with anyone I know!

possibly time to get back in to research:\
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Local research for local people (sorry had to have my 'League of Gentlemen' moment =D)
 
^^I don't think so, though if I'm wrong it wouldn't be the first time (not even today, LOL) but his trip report (still right at the top in the trip reports forum) had alot to do with it's popularity.
 
any major dude said:
also things like escaline & proscaline have rather high dosages & thus lower profit margins. Also, from what i recall in pihkal they weren't terribly interesting.
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They are still enjoyable. It might require more space, but unless you have more than you can carry I dont see the need for preferring chemicals active in micrograms.

I prefer drugs with dosages similar to escaline and proscaline because I feel safer eye balling it.
 
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