New Drugs in the future???

[atara]

don't know as to his claims of being the first to visualise the double-helix structure though... maybe he took lsd and then convinced himself he had discovered it but was just tripping balls at the time.

The way it happened was, Watson and Crick proposed a helical structure, but they had it wrong at first, with the nucleotide base pairs on the outside and the glycophosphate chain on the inside. Franklin had proposed some wierd crystal structure, not a helix.

Later, Watson and Crick rearranged their ideas, based on findings from Franklin, to say the bases were on the inside. This was later shown to be correct.

 

[fastandbulbous]

Well duhh... Name one drug dealer or even a legit chemical company the ISN'T in it for the money. Sorry to hear about yer episode(that's y I always carry benzos whenever I trip). Drugs are dangerous, the same shit u described happens on the street aswell all the time, especially with opiates and Epills. It's because its such a grey market thing. If these vendors wanted to spend all the extra cash to make their company legit and then provide private individuals like us with easy access to the drugs we seek then they are just asking to get shutdown, sued, jailed... Unfortunatly cuz of the laws the way they are there just can't b any regulation. All the companies I knew of that sold these things for decent prices that were legit are now regretting it. It sux but that's the way govs make it

Yeah no-ones in it to be a charity, but there are vendors that care about what they sell and don't want to cause anybody distress (and as such generally have some understanding of organic chemistry names) and there are others that only see pound signs and couldn't give a fuck. A pretty wide chasm exists between the two

 

[Phener]

Yeah no-ones in it to be a charity, but there are vendors that care about what they sell and don't want to cause anybody distress (and as such generally have some understanding of organic chemistry names) and there are others that only see pound signs and couldn't give a fuck. A pretty wide chasm exists between the two

amen to that, seems the latter are dominating the market at the moment $$$ which sucks - analogue laws here we come

 

[Hammilton]

IIRC, franklin had one of the two look at her crystallography, see if she was right, and then proceeded to publish "their" results w/o her.

 

[PsychedelicPeptide]

Peptides alert the immune system and don't usually cross the BBB. Now, peptides are great drugs, intrathecally -- just look at w-conotoxin!

Well you are just a hater, aren't you?

First of all not every peptide is going to "alert the immune system." A well-designed molecule will have sufficient target potency to keep doses small thus rendering the probability of immune reactions minimal.

Besides you shouldn't be taking powerful psychedelics on a daily basis anyways so I don't see where this is a legitimate concern.

Second of all your apparently outdated view of peptides not crossing the BBB thus not being viable for CNS targets can be overcome rather easily by intranasal delivery, assuming the analog is sufficiently stable and soluble to pass the nasal cavity quickly without compromising proteolysis.

But these are things someone like myself is more than aware of. Anyways I think modern techniques to alter peptide physical properties such as fatty acid acylation and covalent stabilization for small helices will be of more importance than nasal delivery itself.

 

[fryingsquirrel]

Yeah no-ones in it to be a charity, but there are vendors that care about what they sell and don't want to cause anybody distress (and as such generally have some understanding of organic chemistry names) and there are others that only see pound signs and couldn't give a fuck. A pretty wide chasm exists between the two

True, but there is also a wide chasm between the the masses buying unknown powders from dodgy vendors and the elitist drug snobs here on ADD who get to try a huge variety of interesting drugs that few people will ever hear of. They are happy snorting god knows what and we're happy experiencing things few ever will. And you are an inspiration to us all.

 

[fastandbulbous]

Think I'll start putting that after my name - fastandbulbous E.D.S. Sounds like I've got an award for services to drug piggery!

 

[Top_Cat]

BTCP and the thiophene-amphetamine-analogues were both reported to be offered by some RC dealers. I do not buy from any of them and can't confirm this though. But the reports are still somewhere here in ADD.

- Murphy

the main cunt behind these never got anything other than Ethylphenidate out if i'm correct and now he is "under maintenance", BTCP was pulled before they 'opened' and another chemical changed, I believe because of this forum...

as for the naming that may have been coincidental given his products other names....

Mods please delete post if too close to vendor discussion​

he had told me that he could recreate nearly all the wonders of PIHKaL with thienyl/phenyl ring substitutions... sounded like bull though

cunt was s'posed to be sending me a full sample range aswell....

 

[MurphyClox]

Thanks for that info. And good to hear that the guy was silenced.

 

[stormyweathers]

IIRC, franklin had one of the two look at her crystallography, see if she was right, and then proceeded to publish "their" results w/o her.

they broke into her lab and stole it.
she died not knowing that her work helped prove the structure.
and since the nobel prize cannot be awarded posthumously, waston and dick still have the credit.
they later confessed.

 

[Top_Cat]

Thanks for that info. And good to hear that the guy was silenced.

i know it could have been spectacular (at least in variety) but would have lead to scottish rhea law being applied to everything- the crime being in the intent (i.e. a substance which gets you off, becomes heavily restricted or completely illegal) there's something similar in norway I believe?

In my communications with him it seemed like a new dawn to the RC market but his actions (media-wise) were appalling mis-direction only works if they don't continue looking at you

 

[atara]

Well you are just a hater, aren't you?

First of all not every peptide is going to "alert the immune system." A well-designed molecule will have sufficient target potency to keep doses small thus rendering the probability of immune reactions minimal.

Besides you shouldn't be taking powerful psychedelics on a daily basis anyways so I don't see where this is a legitimate concern.

Second of all your apparently outdated view of peptides not crossing the BBB thus not being viable for CNS targets can be overcome rather easily by intranasal delivery, assuming the analog is sufficiently stable and soluble to pass the nasal cavity quickly without compromising proteolysis.

But these are things someone like myself is more than aware of. Anyways I think modern techniques to alter peptide physical properties such as fatty acid acylation and covalent stabilization for small helices will be of more importance than nasal delivery itself.

Man, I should have known better than to argue about psychedelic peptides with the guy named psychedelicpeptide.

Yes, you can get things past the barrier intranasally. Yes, you can dodge the immune system. Yes, you can block degradation by peptidase.

But these things are hard; so hard, in fact, that even ligands for peptide receptors (oxytocin receptor, opioid receptors) are commonly non-peptides (WAY-267464, morphine). The most powerful computer cluster in the world is being used to predict protein folding, because it's so damn hard. It is comparatively much easier for a genius to synthesize hundreds of active compounds in a warehouse in his backyard.

 

[PsychedelicPeptide]

I make peptides. It is not so hard once you get started and the chemical space is growing to enormous proportions thanks to immense numbers of commercially available unnatural amino acids with special protecting groups and additional techniques for example secondary structure stabilization or attachment of more exotic things such as fatty acids, sugars and even small molecules.

The primary advantages for peptides are then the potential for stronger target affinity due to increased binding surfaces along with that a greater number of sites in the molecule to do things with and the potential for longer half-lives (assuming you use some tricks to prevent general deactivation/proteolysis and/or enhance circulation time).

Designing peptides from scratch is much more feasible than it may sound if you have access to quality structures or models of desired targets. Proteins like the serotonin receptor and serotonin transporter can easily be modeled using existing structures of homologous entities.

Then the scientist is left to fill in the holes regarding a desired mode of ligand binding and with a little luck and lots of hard work you may see new short peptides (think less than 20 amino acids) doing things that small molecules were once king of.

Perhaps the largest barrier lies in not letting your mind be strapped down by conventional perspectives and to simply imagine the possibilities.

 

[carbon unit]

New drugs in the future? I am reminded of the novel by Philip K. Dick The Three Stigmata of Palmer Eldrich .... http://en.wikipedia.org/wiki/Palmer_Eldritch

Eldritch discovered an alien hallucinogen in the Prox system and plans to market it as "Chew-Z," with U.N. approval, on off-world colonies.

In fact, PKD wrote quite a bit on future drugs... some featured in the film adaptations 'A Scanner Darkly' and 'Minority Report'

 

[Top_Cat]

New drugs in the future? I am reminded of the novel by Philip K. Dick The Three Stigmata of Palmer Eldrich .... http://en.wikipedia.org/wiki/Palmer_Eldritch

Eldritch discovered an alien hallucinogen in the Prox system and plans to market it as "Chew-Z," with U.N. approval, on off-world colonies.

In fact, PKD wrote quite a bit on future drugs... some featured in the film adaptations 'A Scanner Darkly' and 'Minority Report'

A Scanner Darkly is an incredible film.. just thought i'd say...

 

[Top_Cat]

but on topic:

sonic?

 

[atara]

I make peptides. It is not so hard once you get started and the chemical space is growing to enormous proportions thanks to immense numbers of commercially available unnatural amino acids with special protecting groups and additional techniques for example secondary structure stabilization or attachment of more exotic things such as fatty acids, sugars and even small molecules.

The primary advantages for peptides are then the potential for stronger target affinity due to increased binding surfaces along with that a greater number of sites in the molecule to do things with and the potential for longer half-lives (assuming you use some tricks to prevent general deactivation/proteolysis and/or enhance circulation time).

Designing peptides from scratch is much more feasible than it may sound if you have access to quality structures or models of desired targets. Proteins like the serotonin receptor and serotonin transporter can easily be modeled using existing structures of homologous entities.

That's new on me. I have only one remaining objection: How is Jon von Meth Lab going to make this for me? MDMA is a simple synthesis.

 

[stormyweathers]

jon von meth lab doesnt make any research chemicals that most people in this board are interested in.

 

[atara]

I want to see some lysergamides. Where's my AL-LAD, PRO-LAD, lysergic acid 2-butylamide, methylisopropyllysergamide, and lysergic acid dimethylazetidide?

 

[mgrady3]

wouldn't AL-LAD and PRO-LAD be analogues of LSD, thus already covered under FAA?
Not saying they wouldn't be interesting to try just that they wouldn't be readily available as RCs (to buy online for instance)