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nasal spray possibility?

how would a coke nasal spray work
say 100mg/ml per spray

take out liquid in spray,disolve 1g of coke in 10ml of water. that all?
 
First you would need Cocaine HCl as base is not H2O soluble, but HCl is

second you need to know the amount of liquid the sprayer you are using emits per spray

thirdly you would then make a solution to a concentration that can be metered out accurately wherein then you know the mg/spray whether it be possible to be one spray or multiple sprays
 
how do i make cocaine into the right compound then, its written on the bottle how much the spray sprays per go.
 
LuxEtVeritas said:
First you would need Cocaine HCl as base is not H2O soluble, but HCl is

second you need to know the amount of liquid the sprayer you are using emits per spray

thirdly you would then make a solution to a concentration that can be metered out accurately wherein then you know the mg/spray whether it be possible to be one spray or multiple sprays
Click to expand...
bases aren't soluble in water? wtf is this? seems like someone is lacking basic chemical theory.
 
I did a bit of looking at the drug store today and most of the nasal sprays looked to be pretty useless, but there were a couple that had a pump and were metered to provide a consistent dose. It also appears that the pump can be unscrewed to put any desired solution in. Unfortunately the packages only provided limited information and although it said how much liquid was in the bottle, they didn't mention how many sprays per bottle etc.

I assume I can probably just spray a few times into a very small measuring cup and get a fairly accurate idea of how much liquid is in each spray (or just count the total number of sprays in the bottle) then calculate how concentrated to make my solution that way...

Would there need to be anything in the solution other than distilled water and the active ingredient?
 
Cocaine freebase is soluble in water and does work in a nasal spray. I haven't tried this with actual crack, but I have sprayed coca tea in my nose and gotten the usual buzz.

If base wasn't H2O soluble, coca tea wouldn't work at all.
 
Listen, this is ADVANCED drug discussion, and no one here can remember to PUT SOME SALT in the nasal spray? Placing water into orifices is not a good idea unless it's saline. It can be painful and damaging. Just add like .1ml volume of salt for every 10ml of water to protect your nasal passages. It also feels better.
 
^nah, you're exagerating about adding NaCl there.
there's no place for more solute there if you really want to spray a solution with a reasonable drug concentration. adding salt will only make it harder to dissolve more of the desired drug. that's totally against the spray principle since you can't spray a lot of solution into your nose all at once because all you'll get is a huge drip.
 
I do niot have hands on expertise here, but:

Freebase
Main article: Freebase (chemistry)
As the name implies, “freebase” is the base form of cocaine, as opposed to the salt form of cocaine hydrochloride. Whereas cocaine hydrochloride is extremely soluble in water, cocaine base is insoluble in water and is therefore not suitable for drinking, snorting or injecting. Whereas cocaine hydrochloride is not well-suited for smoking because the temperature at which it vaporizes is very high, and close to the temperature at which it burns; however, cocaine base vaporizes at a much lower temperature, which makes it suitable for inhalation.

Smoking freebase is preferred by many users because the cocaine is absorbed immediately into blood via the lungs, reaching the brain in about five seconds. The rush is much more intense than snorting the same amount of cocaine nasally, but the effects do not last as long. The peak of the freebase rush is over almost as soon as the user exhales the vapor, but the high typically lasts 5–10 minutes afterward. What makes freebasing particularly dangerous is that users typically do not wait that long for their next hit and will continue to smoke freebase until none is left. These effects are similar to those that can be achieved by injecting or “slamming” cocaine hydrochloride, but without the risks associated with intravenous drug use (though there are other serious risks associated with smoking freebase).

Freebase cocaine is produced by first dissolving cocaine hydrochloride in water. Once dissolved in water, cocaine hydrochloride (Coc HCl) dissociates into protonated cocaine ion (Coc-H+) and chloride ion (Cl– ). Any solids that remain in the solution are not cocaine (they are part of the cut) and are removed by filtering. A base, typically ammonia (NH3), is added to the solution. The following net chemical reaction takes place:

Coc-H+Cl– + NH3 → Coc + NH4Cl
As freebase cocaine (Coc) is insoluble in water, it precipitates and the solution becomes cloudy. To recover the freebase in the "traditional" manner, diethyl ether is added to the solution. Since freebase is highly soluble in ether, a vigorous shaking of the mixture results in the freebase being dissolved in the ether. As ether is practically insoluble in water, it can be siphoned off. The ether is then left to evaporate, leaving behind the nearly pure freebase.
 
The cocaine alkaloid is soluble in water that has had its pH raised slightly by the addition of a base, like Ca(OH)2. I can only reiterate that, if this weren't the case, coca tea would not work.
 
Yes but we are talking about getting a concentration that is usable for nasal spray administration...

as a tea in hot water it is soluble perhaps, but i still suspect poorly so as in one is getting a solution that is quite dilute

just a conjecture...and we were not talking about using base agents or such which may or may not be practical...

anyway, ...
Cocaine — Solubility in Water: 1800 mcg/mL (20 °C)

Obviously moreso in hot water
 
Basifying, extracting with hot water, and using as a nasal spray is practical. I've tried it and it works. I'm sure you can't make the spray anywhere near as strong as if you were simply dissolving cocaine HCl in water, and if someone really wanted to use cocaine as a nasal spray that's definitely what I'd recommend, but freebase is soluble enough (in pH ~9 soln) to work.
 
Don't use codeine.

You can't use codeine any way other than orally - it has to be metabolized into morphine to have any effect.
 
Creating bespoke nasal sprays

NB: please note all discussion of figures are purely hypothetical and are simply illustrative

First, all this discussion about dosing has been answered above. Choose your nasal spray (pharmacy method), empty contents, clean. Then fill entirely with saline solution. Now spray normal dosing into the air, keeping count of how many, until the bottle is empty. Take volume of bottle/number of doses available = the volume per dose. Then if using pills I would have thought you would prepare as if for IV to concentrate the active substance. Now the maths. If for example you have already experimented and know that your 5ml bottle will give 30 doses (for example), add your filtered acive solution accordingly (eg - if your usual 'hit' of OC is 20mg, you're looking at turning 600mg of OC into saline solution of 5ml (or 300mg to 2.5 ml, or 150mg to 1.75ml tc etc)....or heed the warnings above and half your normal hit (due to increased efficacy of this method).. Or if you wish to control the dosing better (eg - have a choice of 5/10/15/20 mg OC - giving you the option of 1 to 4 squirts).

A much easier way (web method) is to to procure an empty 'nasal solution dispenser' from the web-net-work
01_Nasal_Sprayers_5types.JPG


Where you can get to choose from a selection of bottles, ranging from 0.01-0.5 ml per dose/squirt (+/- 10%). This options allows for more precision and flexibiliy. If you have a high ml per dose ratio (eg 0.1ml per dose) you can opt for a higher dosing bottle to keep the squirting withing an acceptable range (2-5 for a hit). Higher concentrated solutions can be used with the 0.01-0.10 dosing bottles. I woud still experiment, and err of course on the side of caution, if you find your 'end product' is too weak, add incremental ammounts of acitve solution until you hit the sweet spot (taking note of additional quantity added, to facilitate your next bottle prep). Conversely, if results are too strong and 1 squirt has you on your arse, empty bottle into sterile container and add more saline etc (NB - try and keep the process sterile (eg buy sterile saline solution, rinse dispenser with cleaning alchohol etc)

Result - A bottle of innoccuous looking saline solution, a couple of squirts of which will give you the exact dose you require. (you can even print off your own 'pharmacy label' - be creative, call it 'allergeneze', list ingredients, make your own logo, add a 'may cause drowsiness' warning, add a Sanofi logo etc etc)

Iam currently awaiting delivery of a selection of bottles to experiment with creating a methylphenidate nasal doser. I will report back on progress. My plan is to use a 10ml/0.1ml doser bottle, which I plan to fill with a mixture of saline + 100 x 10mg mehylphenidate tabs - and here is where I'm asking advice from you bluelighters.

First I am assuming a 10mg/ml ratio is fine? I'm thinking yes.
Second, how to turn 100 binder/filler-filled tabs into a pure Methylphenidte solution I can work with. Is there any reason why the IV prep method, upscaled to 100 tabs, wouldn't work? Would CWE, cooking, alcohol come in to the equation? I plan to use plenty of water to dissolve the tablets as I will evaporate off water from filtered/resultant solution, hopefully leaving me with 100 mg pure MPH powder to add to my 10ml saline, add to bottle, shake well, and squirt away!!. Surely worth the effort? Anyone know of a sustance one can add to the solution to aid intranasal absorbption?

This seems to me an excellent method of administration, particulalry for those of us who like insufflating pills. I will edit with updates, any suggestions for improvement of method much appreciated.

If my maths is poor in places I apologise, but hope you get the general gist.
cheers.
'GNOTHI SEAUTON'
AN
 
e1evene1even said:
I did a bit of looking at the drug store today and most of the nasal sprays looked to be pretty useless, but there were a couple that had a pump and were metered to provide a consistent dose. It also appears that the pump can be unscrewed to put any desired solution in. Unfortunately the packages only provided limited information and although it said how much liquid was in the bottle, they didn't mention how many sprays per bottle etc.

I assume I can probably just spray a few times into a very small measuring cup and get a fairly accurate idea of how much liquid is in each spray (or just count the total number of sprays in the bottle) then calculate how concentrated to make my solution that way...

Would there need to be anything in the solution other than distilled water and the active ingredient?
Click to expand...

VICKS SINEX has a top that is easily popped off and on.....
 
soundthecymbals said:
Don't use codeine.

You can't use codeine any way other than orally - it has to be metabolized into morphine to have any effect.
Click to expand...

First part is wrong wrong wrong. Any method of admin that features it passing through the liver will work (IV should work then too, but then you have the issue that it will just cause massive histamine release before this happens, making your lungs fill with fluid and thus you potentially dying - oops).
For example, plugging codeine = win. Much less nausea, I find. (but the local histamine release can cause some amusing situations :! !)
 
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