During WWII NAZI scientists studies many opioids and determined that Eukadol (Oxycodone) was the closest to Cocaine regarding its euphoric subjective effects. The original patent states “profound euphoria and a potent narcotic opioid analgesic.
I find it very interesting that Ritalin (Methylphenidate) & Oxycodone were the only 2 drugs to EVER give me true euphoria. And Ritalin & Cocaine are nearly identical in their MOA, both “Inverse Agonists” both releasing/increasing Dopamine in the brains reward centre Stratum Nac (Pleasure & Reward)
Ritalin - DAT>NET
Cocaine - DAT>SERT>>NET
Ritalin is nearly twice as potent than Cocaine at inhibiting DAT (ED-50) effective dose to inhibit 50% of Dopamine Transporters = required to experience euphoric subjective effects / reinforcing dopaminergic pleasure.
Ritalin will ALWAYS win out because it’s 100% pure pharmaceutical grade….and not some pathetic weak, cut, shit that’s passed through 10 freaking degenerates who adulterate the 80% pure Cocaine alkaloid to 60, then 45, 30, 20……pathetic dry, crumbly, trash. Pure Cocaine straight from jungle in Columbia is so oily, moist, shimmery sparkling diamonds smelling of ether / gasoline …..would melt in your hands from body warmth, fingers so oily from touching this amazing tropaine alkaloid, triple reuptake inhibitor, inverse agonist ….the ultimate antidepressant & euphoriant / Dopamine, Serotonin, Norepinephrine all increased in the brains reward centre …..damn. Just pure fckn Sex.
Pure Cocaine and pharmaceutical Diacetylmorphine (Heroin) in the same 30 gauge 1cc insulin syringe, injected directly into a vein and in 3-5 seconds the most insainly pleasurable feeling of warmth & euphoric bliss wash over every fibre of your being , your brain just climaxes with endorphins & dopamine …..ughhhhh ……damn those 3-5 years of injecting speedballs, quality Heroin, scripted Oxycodone & Dilaudid (Hydromorphone), quality Cocaine and scripted Ritalin (Methylphenidate) those cold winters,,,,,inside all winter safe & cozy injecting powerful narcotics 4-5 times daily, watching documentaries warm & cozy inside, watching the snow falling outside after taking a FAT shot of Cocaine & Heroin lol……my lord.
Oxycodone synthesized from theBaine is an opiate alkaloid featuring stimulating properties, as apposed to the sedative properties for morphine type opioids (morphine, diamorphine, hydromorphon, etc) Oxycodone is an uplifting, energizing, Profoundly Euphoric Bliss ….both dopaminergic & mu-opioid agonist properties
Ritalin 20mg & Oxycodone 10mg taken by a naive individual would be pure ecstasy lol. My GF is a school teacher and librarian (such a square lol) I would LOVE to give her a drink with these two drugs dissolved inside…..and see her behaviour change in 30-45min lol. She has never taken a dopaminergic/opioid candy bar in her life.
it would make her CNS cum with euphoric ecstasy……but ethically I could never do that without her knowledge & consent. I’d absolutely love to though…..she has Nooooo freaking idea on how insainly pleasurable Ritalin & Oxycodone are