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Opioids Methadone

Methadone don't really have blocking effects. Hydromorph and a few others have higher binding properties and fentanyl would definitely get through. I was ok on 60 but like most i went up more then needed trying to catch a buzz. I took 40mg of oxy when i was on methadone and i felt it.

If you're not in withdrawl or craving bad i would just stay at 60mg. The higher you go the longer to get off of it. But if you're craving bad go for a higher dose before taking street drugs. In 15 years of pretty heavy use last year i used something i never though i would, fentanyl, when i got off methadone and i od'd. 80 isn't extremely high but please take more methadone then street fent.
In my previous reply I was an apposition to this theory

….of being long term stable on daily Methadone 80mg for years + and being able to use Dilaudid, H, etc, other certain opioids. I would’ve said NO

But….last week I was 1.5 days without my daily Methadone 80mg and legs soar and painful, typical discomfort. I’ll NEVER I.V. drugs ever again. SO ….Hydromorphone HCL XR beads pulverized slightly warmed and swirled around to dissolve all that water soluble HM drawn up in a 1cc oral syringe

Laying on bed insert slightly and pushed warm solution into rectum……..within minutes 3-5 an unmistakable warmth and comfort took over, leg pains gone, felt warm inside brain and could taste the HM ….it DID work with 1.5 days of abstinence

The smell of Zippo lighter fluid still does something to my brain….I can smell and taste shooting junk, real quality Heroin 10-15 years ago before that dirty commie Fent infected entire supply chain. Injecting my massive monthly scripted Dilaudid 2mg & Hydromorph-Contin XR 9mg blue capsules

F@ck…..that winter I’ll never forget……safe & warm inside my house watching awesome docs, etc, banging serious sh!t 5-8 times daily. Morning before breakfast even…..a FAT shot and a cigarette. The euphoric pleasure of injecting Oxycodone, Hydromorphone and illicit Heroin of excellent quality no joke, amazing H, light tan, strong vinegar odour and banging was a unique rush unlike others…..more potent and euphoric relaxation

After that ……cold turkey…..month of hell. now it’s daily dose Methadone 80mg
 
The doses of methadone for visceral pain are generally much lower than doses used for methadone maintenance and if that dose works for you - it's a good choice.

Why a doctor would add morphine I don't know. Is it for breakthrough pain?

The toxicity of methadone is dose-dependant and risk of cardiotoxicity isn't uniform, their is a genetic predisposition.

I'm not a doctor and so I would be fairly confident that a doctor would seek to provide the best outcome.

IF your doctor doesn't know about the methadone and vice versa, I would be honest. When given for pain methadone is prescribed [BID] or even [TID[. This means it's less toxic AND increases it's analgesic properties.
Sorry for not replying. I typed the post but apparently didn't hit reply.

Well my case is a mess, but I don't want to bore people with my life story so short version - due to some wrong diagnosis when I was younger only option for me to get pain relief (I live in EU) was through treating opioid addiction. So with nowhere to go as I had "red flags" due to said past mistakes by doctors I am treating pain in this manner. And for the "why morpinineon top of methadone" question I sure hope that I will be able to replace almost all methadone (15-20mg I could live with) with morphine. My doc is not a chatty bloke so I can only assume that this is his train of thought also. I mean why would you prescribe SR formulation of morphine if it is only for a brake through pain? 50 or even 40 is a pretty hefty methadone dose for my body and it comes with many side effects i don't like. So I truly hope to crossover to only morphine but I can not do a thing about it but wait, tell how I feel and see what happens in the future.
 
Im not looking forward to when I eventually decide to come off....if ever.....Im currently on a once daily dose of 240 mgs. I get that from the Safe Supply program here in Canada, with 90 mg of methylphenidate daily (just went up from 80) and 30 mgs of baclofen daily. My close friend gets these meds dispensed daily, and I am not bullshitting; 180 mgs of methadone, 30 of the 8 mg Dilaudid tablets, 80 mg of ER methylphenidate and 110 mgs of IR MPH. keep in mind we are in the grips of an overdose epidemic, caused by extremely powerful Fentanyl dope. said friend recently took some locally available red coloured fent to the testing service, which came back as ~20% fentanyl and ~2% bromazolam. which translates to every 0.1 of this particular batch of "down" containing around 20 mgs of fentanyl and 2 mgs of bromazolam. When you take into account the fact that people are smoking a gram a day on average of this, (200 mgs of fent) the 30 dillies and methadone doses make a lot more sense. I was smoking about 5 grams of down a day, but 240 mgs of methadone holds me without dilaudid so, i dont get them.

They started recently giving out vials of 10 mg/ml hydromorphone for IV injection as well. This is in Ottawa Canada. as for the morphine on top of methadone as Pain in vain addressed, in pain cases it may be for synergy or breakthrough. here it is used in high doses with methadone for opioid maintenance. a random example maybe someone might get a daily dose of 150 mgs of methadone as well as 1700 mgs of morphine. my understanding is to prevent withdrawal from severe dependance and to possibly curb cravings. though I think high dose oral and IV dilaudid may be what is prescribed more for breakthrough cravings
 
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Just out of interest - why the increase in methylphenidate? To offset the soporific effects of the methadone?

I contacted the Canadian government department that deals with the drug problem noting that R-4066 is a methadone analogue that is some x414 more potent and has such a long duration of action that clients can take it every 48-72 hours.

Given the cardiotoxicity of methadone and the levels of dependence some people must reach, I just don't think methadone is going to be practical.

Carfentanil is also turning up in Canada and it's got a longer duration of action (than fentanyl) so it's popular with users. It's also x100 more potent than fentanyl, so it's popular with 'cooks'.

I've known of five chemists who broke rule 1. Two are dead, one is in prison, one was still in the acute phase of withdrawal (after 12 months) and one recovered after two years. They were IVing between one and two grams of pure fentanyl a day. They had to rig up cannulas and syringe-drivers so that they could sleep (since they needed a hit every 20 minutes). And that was just fentanyl - carfentanil, the stuff used to knock out elephants? Who KNOWS how to treat that dependence.

But R-4066 is the only practical thing I could think of. 10mg/day would stop someone doing a gram of fentanyl a day from withdrawal.
 
Just out of interest - why the increase in methylphenidate? To offset the soporific effects of the methadone?

I contacted the Canadian government department that deals with the drug problem noting that R-4066 is a methadone analogue that is some x414 more potent and has such a long duration of action that clients can take it every 48-72 hours.

Given the cardiotoxicity of methadone and the levels of dependence some people must reach, I just don't think methadone is going to be practical.

Carfentanil is also turning up in Canada and it's got a longer duration of action (than fentanyl) so it's popular with users. It's also x100 more potent than fentanyl, so it's popular with 'cooks'.

I've known of five chemists who broke rule 1. Two are dead, one is in prison, one was still in the acute phase of withdrawal (after 12 months) and one recovered after two years. They were IVing between one and two grams of pure fentanyl a day. They had to rig up cannulas and syringe-drivers so that they could sleep (since they needed a hit every 20 minutes). And that was just fentanyl - carfentanil, the stuff used to knock out elephants? Who KNOWS how to treat that dependence.

But R-4066 is the only practical thing I could think of. 10mg/day would stop someone doing a gram of fentanyl a day from withdrawal.
I increased the methylphenidate due to tolerance and my doctor decided to increase it after I told him I was experiencing cravings for illicit stimulants (e.g methamphetamine, freebase cocaine etc)

as far as the methadone goes, I think it will probably stay since its established itself as the "gold standard" of opioid maintenance drugs. I believe they will simply use traditional-highish doses, in addition to high dose 24 hour release morphine formulations (Im talkin like 2000+ mgs in many cases) along with high doses of oral hydromorphone and IV hydromorphone vials for cravings. I think the government here has realized its less taxing and harmful on society as a whole to just allow ppl who want to access recreational drugs and/or maintenance drugs for addiction/dependance to do so.

I think they should just start giving out more fentanyl patches and even IV vials of fentanyl citrate to users who need it. It is approved for the safe supply here, as are diacetylmorphine dry ampules, but I rartely if ever see them.
 
Wow - I remember when fentanyl citrate was only available as Sublimaze and was only used as part of general anesthesia. and the PIL specified that artificial ventilation should be available.

I presume fentanyl is given to people with huge levels of tolerance.

Europe hasn't seen the fentanyl epidemic YET but I think it's only a matter of time.

But I've noted that, at least in this town, that most people receiving opiate-substitution therapy have to pick up their medicines every day. I suspect it's so that people eventually get tired of having to take a (sometimes long) trip to the pharmacy where supervised consumption is required in most cases.

When fentanyl hits, I can honestly see the UK choosing R-4066 because it's slow onset and long duration stop physical withdrawal symptoms and cravings... and it's affinity is so high it will blockade fentanyl or, at least dull it's effects so taking it doesn't produce a flash or a high.

Cravings - local drug services provide counselling. Yes, we ALL know it doesn't work but the mindset is that managing cravings can be learnt.
 
Wow - I remember when fentanyl citrate was only available as Sublimaze and was only used as part of general anesthesia. and the PIL specified that artificial ventilation should be available.

I presume fentanyl is given to people with huge levels of tolerance.

Europe hasn't seen the fentanyl epidemic YET but I think it's only a matter of time.

But I've noted that, at least in this town, that most people receiving opiate-substitution therapy have to pick up their medicines every day. I suspect it's so that people eventually get tired of having to take a (sometimes long) trip to the pharmacy where supervised consumption is required in most cases.

When fentanyl hits, I can honestly see the UK choosing R-4066 because it's slow onset and long duration stop physical withdrawal symptoms and cravings... and it's affinity is so high it will blockade fentanyl or, at least dull it's effects so taking it doesn't produce a flash or a high.

Cravings - local drug services provide counselling. Yes, we ALL know it doesn't work but the mindset is that managing cravings can be learnt.
Yes here for the hydromorphone program, you have to pick up your 30 dilaudid tablets daily. though, at least where I am, there are a few locations across the city where this can be done. I agree that we need to do more with therapy though. I dont believe drugs themselves are the problem, its that there isnt enough focus on mental health, but its getting better. In my city, it seems every addict has a co-occuring mental health disorder. and it seems as much as 50-60% of them have a serious illness like schizophrenia. people suffering what appears to be ongoing/permanent paranoid delusions from exessive methamphetamine abuse seems to be extremely common as well.

I think we just need to regulate and legalize recreational drug use. I mean, here in Canada, Cannabis is legal for recreation, there seems to be 1 or more marijuana stores on every city block, we can buy alcohol, and tobacco and small amounts of codeine. why not legalize the others? Id literally have to walk further from my doorstep to buy weed/booze/cigarettes than Id have to walk to score fentanyl or speed or coke. most urban centers have large open air illicit drug markets anyways, with unregulated, uncontrolled and many times dangerously potent narcotics. I mean the safe supply is just a step away from doing that anyways, all you have to do is say you are addicted to or use street drugs for recreation or pain and you are concerned about the tainted drug supply and you will leave with an Rx alternative to your DOC. so really its legal, but u need a signed piece of paper... If you go in and say you use Fentanyl, you will get Methadone,Dilaudid,Morphine or all 3 together (potentially Heroin or fentanyl as well if you asked I guess) if you use crack/coke or street speed, you will get high dose methylphenidate, lisdexfetamine, dextroamphetamine or adderall. Its a step in the right direction, but that alone wont solve the addiction crisis. certainley it will likely help the overdose crisis, and already seems to be cutting down crime, since people dont have to steal from stores or homes or people to get a fix anymore.
 
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Literature I found lists 20mg == 150 oral morphine, which would put you around 600mg oral morphine. A sizeable habit
 
I know many people who get high on methadone. There's drugs with higher binding affinity that will break through methadone. Buprenorphine fentanyl and hydromorph are 3 but there are more
While bupe has a higher binding affinity I think you’ll get sick as shit if you take it while on methadone.

I’ve never tried it but asked here if I could safely take bupe with out precipitated withdrawal on 5 mg of methadone per day and they said don’t even try that.
 
While bupe has a higher binding affinity I think you’ll get sick as shit if you take it while on methadone.

I’ve never tried it but asked here if I could safely take bupe with out precipitated withdrawal on 5 mg of methadone per day and they said don’t even try that.
here what they do is get ppl to a low dose of methadone, like 20 mgs or less I believe, and then begin microdosing people with bupe. like 0.125 mg at a time, and titrate up. Im not totally sure if they do this while maintenance with methadone is ongoing, or if you quit the low dose methadone for a cpl of days. Ive had different ppl tell me they use both methods, and since I find many,if not most, street addicts have no idea what they are talking about and just repeat nonsense they heard from another user who has no idea what they are talking about, so I dont believe anything anyone on the street tells me until I research it or hear it from a pharmacist or doctor. Ill ask my pharmacist this morning when I go to pick up my methadone
 
Yes here for the hydromorphone program, you have to pick up your 30 dilaudid tablets daily. though, at least where I am, there are a few locations across the city where this can be done. I agree that we need to do more with therapy though. I dont believe drugs themselves are the problem, its that there isnt enough focus on mental health, but its getting better. In my city, it seems every addict has a co-occuring mental health disorder. and it seems as much as 50-60% of them have a serious illness like schizophrenia. people suffering what appears to be ongoing/premanent paranoid delusions from exessive methamphetamine abuse seems to be extremely common as well.

I think we just need to regulate and legalize recreational drug use. I mean, here in Canada, Cannabis is legal for recreation, there seems to be 1 or more marijuana stores on every city block, we can buy alcohol, and tobacco and small amounts of codeine. why not legalize the others? Id literally have to walk further from my doorstep to buy weed/booze/cigarettes than Id have to walk to score fentanyl or speed or coke. most urban centers have large open air illicit drug markets anyways, with unregulated, uncontrolled and many times dangerously narcotics. I mean the safe supply is just a step away from doing that anyways, all you have to do is say you are addicted to or use street drugs for recreation or pain and you are concerned about the tainted drug supply and you will leave with an Rx alternative to your DOC. so really its legal, but u need a signed piece of paper... If you go in and say you use Fentanyl, you will get Methadone,Dilaudid,Morphine or all 3 together (potentially Heroin or fentanyl as well if you asked I guess) if you use crack/coke or street speed, you will get high dose methylphenidate, lisdexfetamine, dextroamphetamine or adderall. Its a step in the right direction, but that alone wont solve the addiction crisis. certainley it will likely help the overdose crisis, and already seems to be cutting down crime, since people dont have to steal from stores or homes or people to get a fix anymore.

Also in Canada….I can “legally” Purchase online LSD-25, Psilocybin, Cannabis, DMT, Ketamine, MDMA (of questionable purity & chemical makeup…by NO means 100% pure pharmaceutical grade MDMA) sketchy garbage and probably made up of several obtainable analogs selling under the guise of MDMA)

Tylenol # 1 or whatever, weak @$$ shit, Ohhhh 8mg of Codeine, 25mg Caffeine, 325mg Acetaminophen…..you would be hospitalized of liver failure due to a MASSIVE acetaminophen toxicity in a reckless attempt to get “high” of low dose weak ass Codeine

However ….in Canadian PF Codeine-Contin 200mg scored tablets (25/50/100/200mg tablets). An opioid naive patient would feel great from a 200mg tablet of Codeine, or a few.

These colour tablets tablets look like candy to me….I have a morbid attraction to all CII controlled substances

Hydromorph-Contin 3/6/9/12/18/24/30mg XR capsules with pretty coloured capsules (Red-Rockets 30mg)
Dilaudid 2/4/8mg tablets

Oxy-IR 5/10/20mg tablets
OxyContin 20/40/80/160mg tablets (damn those exotic blue 160mg OC tablets) those PF green CDN 80’s.

Metadol (Methadone) 1/5/10/25mg scored tablets

Dexedrine 5mg tablets
Dexedrine Spansule 5/10/15mg “Halloween Candies” lol

Adderall XR 5/10/15/20/25/30mg capsules (those classic 30’s are like Gold)

Ritalin 5/10/20mg IR tablets
Biphentin XR 10/15/20/30/40/50/60/80mg coloured capsules (Methylphenidate 40/60 XR beads)

Diazepam 2/5/10mg tablets
Alprazolam/Lorazepam/Clonazepam

They all look like pure fckn Sex…..it’s like looking at pornography to me, I get aroused and a desire to obtain 10,000 tablets/capsules of each CII substance ….like XXX rated candy.

Dopaminergic euphoric pleasure (DAT/NET/SERT / Mu-Opioid agonists / GABA-A PAM’s)

Dopaminergic stimulants / Opioids / Anxiolytic & Muscle Relaxation

NOTE: Currently in B.C. Canada (due to sickening amounts of deaths due to title wave flood of commie Fentanyl from China the Government has been prescribing I.V. Diacetylmorphine (Heroin) & injectable Hydromorphone, in addition to many services such as safe injection site and services to “get your drugs tested” which use lab grade equipment to analyze that unknown powdered substance you’ve obtained off the streets. Oral Methadone is great by many need to bang that sh!t for that euphoric warmth & relaxation. Clean new fresh needles, medical staff on site, and pharmaceutical Diamorphine & Hydromorphone for injection. Crack/Cocaine/Meth addictions are often treated with oral XR Amphetamines (Adderall 30’s X 4 daily or Dexedrine Spansule 15mg X 4 daily in addition to IR Dexedrine 5mg tablets. It’s a cluster f@ck over there. I’m in Ontario other side of the country

Through Health Canada’s “Special Access Program” any physical can order in Desoxyn (d-Meth), Diamorphine (Heroin) or any other highly regulated controlled substances not currently available in market in Canada
 
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Yea been on methadone 20 years , it did save me from being in /out prison, but I think it's over used and over prescribed on upping the dose way to much ,most ppl don't need 100 ml on H ,habit,
 
Also in Canada….I can “legally” Purchase online LSD-25, Psilocybin, Cannabis, DMT, Ketamine, MDMA (of questionable purity & chemical makeup…by NO means 100% pure pharmaceutical grade MDMA) sketchy garbage and probably made up of several obtainable analogs selling under the guise of MDMA)

Tylenol # 1 or whatever, weak @$$ shit, Ohhhh 8mg of Codeine, 25mg Caffeine, 325mg Acetaminophen…..you would be hospitalized of liver failure due to a MASSIVE acetaminophen toxicity in a reckless attempt to get “high” of low dose weak ass Codeine

However ….in Canadian PF Codeine-Contin 200mg scored tablets (25/50/100/200mg tablets). An opioid naive patient would feel great from a 200mg tablet of Codeine, or a few.

These colour tablets tablets look like candy to me….I have a morbid attraction to all CII controlled substances

Hydromorph-Contin 3/6/9/12/18/24/30mg XR capsules with pretty coloured capsules (Red-Rockets 30mg)
Dilaudid 2/4/8mg tablets

Oxy-IR 5/10/20mg tablets
OxyContin 20/40/80/160mg tablets (damn those exotic blue 160mg OC tablets) those PF green CDN 80’s.

Metadol (Methadone) 1/5/10/25mg scored tablets

Dexedrine 5mg tablets
Dexedrine Spansule 5/10/15mg “Halloween Candies” lol

Adderall XR 5/10/15/20/25/30mg capsules (those classic 30’s are like Gold)

Ritalin 5/10/20mg IR tablets
Biphentin XR 10/15/20/30/40/50/60/80mg coloured capsules (Methylphenidate 40/60 XR beads)

Diazepam 2/5/10mg tablets
Alprazolam/Lorazepam/Clonazepam

They all look like pure fckn Sex…..it’s like looking at pornography to me, I get aroused and a desire to obtain 10,000 tablets/capsules of each CII substance ….like XXX rated candy.

Dopaminergic euphoric pleasure (DAT/NET/SERT / Mu-Opioid agonists / GABA-A PAM’s)

Dopaminergic stimulants / Opioids / Anxiolytic & Muscle Relaxation

NOTE: Currently in B.C. Canada (due to sickening amounts of deaths due to title wave flood of commie Fentanyl from China the Government has been prescribing I.V. Diacetylmorphine (Heroin) & injectable Hydromorphone, in addition to many services such as safe injection site and services to “get your drugs tested” which use lab grade equipment to analyze that unknown powdered substance you’ve obtained off the streets. Oral Methadone is great by many need to bang that sh!t for that euphoric warmth & relaxation. Clean new fresh needles, medical staff on site, and pharmaceutical Diamorphine & Hydromorphone for injection. Crack/Cocaine/Meth addictions are often treated with oral XR Amphetamines (Adderall 30’s X 4 daily or Dexedrine Spansule 15mg X 4 daily in addition to IR Dexedrine 5mg tablets. It’s a cluster f@ck over there. I’m in Ontario other side of the country

Through Health Canada’s “Special Access Program” any physical can order in Desoxyn (d-Meth), Diamorphine (Heroin) or any other highly regulated controlled substances not currently available in market in Canada
Yes, we do have it good. being able to buy things like LSD,MDA, and all sorts of psilocin analogs on the clearnet is pretty cool. Rilmazofone is easily to find domestically as well. And in real life, in a 3 block radius from me are A safe supply prescribing and dispensing site, (Methadone, Dilaudid,morphine, amphetamines etc), about 5-6 cannabis stores, and 2 psilocybin mushroom shops. I actually bought 7 grams of penis envy mushrooms from the mushroom store up the street from me a little while ago.

Id like to see more methadone tablets, Ive only ever seen the 25s, and that was in Quebec, which is like 20 mins away from me, so youd think id see em more. I once had some pure methadone hcl powder from the darknet. they capsules that were advertised as 50 mg doses, though dumping out caps and comparing it was noticeable some contained less. so probably like 40-50 mgs approx depending on the cap.
 
Yea been on methadone 20 years , it did save me from being in /out prison, but I think it's over used and over prescribed on upping the dose way to much ,most ppl don't need 100 ml on H ,habit,
This is true, especially in past times, people were on major overkill doses of methadone. people who were using 200 mgs of IV morphine sulfate per day were ending up on 120 mgs of methadone. now the opposite seems to be the problem here unfortunately. Fentayl dope is so cheap and so potent, Dr's are finding that traditional opioids are not able to completely cover a serious fentanyl addicts withdrawal. hence why here in Canada, the doses are so insanely high. a 10$ 0.1 of fentanyl in my area probably on average contains like 10 mgs of fentanyl. thats fucking crazy.

I know a dealer who mixes his own down. he makes 12 ounces of "down" from one ounce of raw fent.
 
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I dont believe anything anyone on the street tells me until I research it or hear it from a pharmacist or doctor. Ill ask my pharmacist this morning when I go to pick up my methadone
I wouldn’t trust most doctors and wouldn’t trust any pharmacist at all over an informed drug addict (ie the ppl on this sub) on this issue. With the exception of a doctor that specializes in addiction medicine. Even pain specialists I’ve heard moronic questions and statements from re opioids.

But I see your point that the typical street addict community is full of urban myths and liars.

The best person to ask would be both a drug addict and a doctor though. These guys know their shit but are hard to find.



I had an MD tell me methadone wasn’t an opioid. Some of them have no idea what they are doing.
 
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Yea I had Doctor she specialises in addiction say ,"u can not get high from subs"
 
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I wouldn’t trust most doctors and wouldn’t trust any pharmacist at all over an informed drug addict (ie the ppl on this sub) on this issue. With the exception of a doctor that specializes in addiction medicine. Even pain specialists I’ve heard moronic questions and statements from re opioids.

But I see your point that the typical street addict community is full of urban myths and liars.

The best person to ask would be both a drug addict and a doctor though. These guys know their shit but are hard to find.



I had an MD tell me methadone wasn’t an opioid. Some of them have no idea what they are doing.
Alot of the pharmacists I know are actually much more versed in pharmacology than any Dr Ive met, I mean certainley there are some, especially at bigger chain outlets I find that are not so in touch, but, I find the pharmacists I talk to who work the small pharmacy that dispenses the safe suppply in my neighbourhood are very knowledgable.
 
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Well I'm not at 60mg I'm at 80mg, I believe you misread that lol. It's okay. And well too be honest, the 80mg has pretty much completely took care of the physical withdrawals (I was using Fentynal) but I'm still having MAJOR cravings. To the point I'm still using like every other day. (Smoking blue Fentynal pills) do you guys think increasing my dose up to 90 or 100mg that will cut down my cravings?? Thank you.
yeah man i’d go up to maybe around 120-130 if you can, as you’re not supposed to be craving while on methadone maintenance that badly. hope all is well, keep us informed! much love
 
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