[Mega] The "Why won't MDMA work for me?" thread

[Freeotrope]

I am also one who seems to have a very high tolerance to MDMA. The first time I tried it was in high school. I had sold a few dozen presses to people and then I tried it and felt nothing, absolutely nothing. Then I heard reports back from people they said they had an amazing time, all describing classic MDMA effects. The second time was someone was a highly trusted friend for whom MDMA was a major part of their life. They said it was lab tested. I tried it and nothing at all. Smoked some cannabis and felt maybe a little tiny something extra. Third time was with another friend who loved MDMA. She felt classic MDMA effects and I felt maybe a little bit, maybe was just resonating with her.

Immune to MDMA?

Here is the situation. A good friend of SWIM has attempted to roll on numerous occasions with me and other peers with no success what-so-ever. The MDMA is without question decent stuff, because SWIM has rolled hard on approx 180mg of it, as do all of SWIMs other friends (all have a slight tolerance as well). Now the interesting part is that SWIMs friend is also non-responsive to opiate drugs; has been given morphine IV at the hospital numerous times with NO EFFECT, very strange. So I am wondering if there is a link between the immunity to opiates and his inability to roll? Had an empty stomach each time... Non of the standard "roll killers" apply to this situation, I believe its something to do with his body? Any ideas? First post on BL btw :D Been trollin for quite a w

This was really interesting for me to read. I also have a really high tolerance/immunity to opiates. I've tried many opiates including IV fentanyl in the hospital. They gave me 2 shots of fentanyl in the hospital. Never felt anything from the opiates either.

MDMA and opiates are metabolized by CYP2D6, and there 1-2% of the population are thought to have a copy of this enzyme that makes an ultra high metabolizer phenotype. This might explain it or be part of the explanation.

I also have a high tolerance to valium and versed. I was once prescribed valium and would take 5 times the recommended dose and still felt nothing. These are metabolized by other enzymes.


I'm thinking the reports in this thread aren't just bunk. In many of the reports there were others who took the same batch who felt something. If it was just bunk than wouldn't everyone feel nothing? In high school I sold that batch to dozens of people and only got positive feedback.

I wonder how much pharmacogenetic testing costs...

 

[Freeotrope]

Also CBD inhibits CYP2D26. it would be interesting to see with preloading with CBD would effect this

 

[hardtack]

Any and all questions regarding MDMA not working for you are to go into this thread.

DO NOT START A NEW THREAD.

Post your question here and it will be answered

-NoT

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I don't know whats wrong with me. my first time taking ecstacy was at my friends house and it was an orange maserati. I felt a light buzz on my body for about 5 mins but then it went away and i was just chill and happy the whole night. it kept me up the whole night and I had to go take a piss every 15 mins. other than that, I didn't feel anything. my friends said i probably didn't feel anything because i just finished eating a whataburger meal not even 5 mins before swallowing the pill with some water. other people said it was probably a bunk so i didn't think much if it after that.

Today, one of my close friends gave me a yellow pisces free so i don't really think they were bunk.(my second pill) So I took this one atleast 2 hours after eating. I took it a different way seeing if it would work, so i let it sit under my tongue for a good minute, chewed it with my front teeth, and then drank the remaining parts with some water.
i was just playing some xbox with some friends till i felt a light body buzz again for a couple minutes and then NOTHING. it had the same effects as last time and im wide awake right now.
whats up with this? am i immune or something? or its seriously just 2 bunks in a row.

haha sorry. im about 6 ft flat and weigh about 170. I have no health problems and i am not on any medication. I was in a pretty comfortable spot on my friends couch. and i was thinking about what it was going to feel like whole time. idk if that affects anything.

You got Bunk , you know it's Good and real first time if you get weezy stomach or craps and then KAPOW it hits you about half hour later and you just wanna Party like you hit the LOTTO. Got so much empathy and feeling of bliss . Just wanna share it with the world. Yeah; got scared first time and then after that the bliss hits and we hit the club I wanted to dance my ass off all night. Yeah definitely get gurning (teeth clenching) so straws from the cranberry & Vodka was a blessing not to mention girls in the club knew I was Rolling ,OK I'm an old fart enough of details on that,,,but yeah those were the real days of XTC from real sassafras , WOW not much of that original power anymore .