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[MEGA] Synthetic Cannabinoid Discussion - Take 4

I've posted this in the other iterations of the official 'noid threads, and I'll do it again for good measure: Synthetic Cannabinoids are NON-TOXIC as a rule. There seem to be a few notable exceptions, usually when people go overboard or are using commercial blends, but I would take a nice foily of CBDs over real bud ANY DAY OF THE WEEK. My significant other feels the same way. We weigh our doses with microgram scales, vaporize off aluminum foil using a candle (lower burn temp than butane), and only smoke a couple times a day.

I get great bud, too. So it's not that.

Either you guys need to find better vendors, or start being more careful with your dosing, because I've been a daily user since 2009 and have yet to experience any real side effect that isn't also present with weed.


(If you overdose, you will not feel well, just like with practically any other drug. That doesn't mean it's "toxic" or "poisonous". Ignorance is poisonous, as is sensationalism. I have personally had a hand in helping research and develop some of the newer 'noids available right now, and am in touch with others in that area. We are well acquainted with cannabinoid QSAR. People aren't just making random pseudopoisons and hoping they work)

EDIT: It IS true that some of the newer ones are orders of magnitude more potent than some of you might be expecting. 5F-PB22, for instance, is OVERWHELMINGLY active at less than 500 MICROgrams (with no tolerance)...an amount not really visible to the naked eye. If you load up a JWH-018 sized dose of 5F-PB22, yeah you'll probably feel 'poisoned' too. But to quote the colloquialism, "The only real difference between medicine and poison is DOSAGE (and intent)."

EDIT2: as another example, 5F-ADB-PINACA and ADBICA are easily active at 100mcg
 
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^^
I feel the same way, in fact I can't wait for my next batch of noids to arrive.
I think the only real problem with them is that if you can't control yourself you can very easily go overboard and tolerance raises very easily with these chemicals, even at "regular" doses
and you end up smoking 1 gram a week. but that's not quite my problem

I don't really prefer noids over weed, it's just that there is really shitty mj going around here and with synths you always know what to expect and they're super cheap

and with a ghetto style lightbulb you can smoke (vape) everyfuckingwhere, which is important to me because I live with my parents and with this method I don't have to worry about the smell and can smoke sitting on a comfy armchair browsing bluelight or playing videogames.

and to who defined them "crackabis", well I think that's the most accurate way to describe noids that I've ever read lol
 
I just find it so fucking annoying that the "commercial" incense blends have been lumped in with noids, demonising them. Nobody's has a clue what these shady vendors are putting in there blends, not to mention the Insane markups they're selling them for. Who knows what RC's, pesticides or god knows what these things contain. Shit, some blends in japan contained the RC opiate ah-791 or whatever it's called. I see nothing wrong with the pure noids themselves; in fact Pfizer briefly marketed one such noid as an analgesic according to wiki.
 
I heard that pfizer developed some of them (ab-fubinaca i think), but i didnt know they actually marketed one?
 
I really don't know I just got it off wiki, (and yeah it was fubinaca) and they're not the be all of knowledge. I can see why a pharma company would do that though; these compounds could be designed to target particular receptor sites, not to mention standardisation; a drug is simply more reliable than a plant, not to mention a drug can be patented. I believe some of the noids which are fucking people up are the ones with huge affinity for the thc receptor. I'm interested in ones with a high affinity for the CB1 receptor myself.

Edit: I remember reading years ago that patients were prescribed a synthetic cannabis pill, but results proved poor. Anyone know anything about this?
 
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Ive looked at a lot of cannabinoids in the jwh-, cp- and am series, a lot of them have affinity only for CB2 and they seem only to have pain-reliving properties, not a high. So maybe this is what the pharma companies were after, i mean a lot of the new ones have much higher affinity for CB2.
 
CB 1/2 ratios are no longer considered to be good predictors of 'IF' a compound will retain psychoactivity, but rather, 'HOW'. We now have examples of compounds which are highly psychoactive yet exhibit low binding at CB1. The CB2 receptor is thought to potentiate CB1 response, so as long as there is some mild CB1 binding, a full CB2 agonist will usually be psychoactive. This is my interpretation of the result of my own research, so I cannot quote a source for this. But it explains why many SELECTIVE CB2 agonists seem almost worthless, and even why SELECTIVE CB1 agonists are often psychoactive, but qualitatively unlike marijuana.

In addition, it explains why mostly CB2-ergic compounds which retain a small (but measurable) affinity for CB1 (UR144) are much more psychoactive than one would expect from their CB1 Ki.
 
i GUESS that makes sense? since as you say, ur-144 has a very high selectivity for CB2. There are some others that do the same, but i havent smoked them so i cant say anything. Good old JWH-018 is also a bit more keen on the CB2 but i doubt its enough difference to CB1 to be relevant. Really, i dont know, but its an interesting theory!

On another note, anyone know how (or by whom) the APINACA, AB-PINACA, AB-FUBINACA, etc, etc, cannabinoids are named?
 
Maybe they're prototype names by the drug companies which are making them? They all sound kind of organic, almost like breed names. I reckon akb48 is blatantly try to steal some of ak47's name recognition.

I've just ordered some pb22; the vendor claim it's far more potent than previous noids they've sold in the past - anyone smoked this one yet?
 
^^^
you mean 5f pb22? I just smoked it once and as far as I can remember (I may be wrong tho) it was a rather mellow high, almost hash-like.
I kinda.recall it even if I tried it only once because
me and my friend recorded a jam while on it and we called it "5f pb22" what fantasy lol

I'm not sure tough so I'd like to hear somone else's reports

P.S. I just ordered some AM2201 and reports say that it is active at even 500ug is it really that potent? how does ot compare to 5f-akb48?
 
dopemegently said:
Maybe they're prototype names by the drug companies which are making them? They all sound kind of organic, almost like breed names. I reckon akb48 is blatantly try to steal some of ak47's name recognition.
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akb48 is the name of a band of .japanese bitches lol (j-pop I believe)
maybe they named it after them?
EDIT sorry for the double post but I'm using my mobile and opera mini sucks ass even tough it's fucking fast
 
ComfortablyNumb95 said:
P.S. I just ordered some AM2201 and reports say that it is active at even 500ug is it really that potent? how does ot compare to 5f-akb48?
Click to expand...

its regarded as being the most potent synthetic cannabinoid out there. i have not tried 5F-AKB-48 so i cannot compare between the two, but AM-2201 has a distinct rush to it that can leave you very anxious. i kept smoking it through the anxiety though, lol.
 
thenightwatch said:
its regarded as being the most potent synthetic cannabinoid out there. i have not tried 5F-AKB-48 so i cannot compare between the two, but AM-2201 has a distinct rush to it that can leave you very anxious. i kept smoking it through the anxiety though, lol.
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heh thanks for the info... but unfortunately is no longer necessary as they won't ship it to my country :p gotta stick to good old akb
 
Guys its a chemical what? No on fkkn knows for fucks sake keeep smoking that fake weed u will die!!!!! Smoke real ! Safe and smells good nasty chem sprayed grass
 
euphoricc said:
Guys its a chemical what? No on fkkn knows for fucks sake keeep smoking that fake weed u will die!!!!! Smoke real ! Safe and smells good nasty chem sprayed grass
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Its not a chemical, its many!

ComfortablyNumb95 said:
akb48 is the name of a band of .japanese bitches lol (j-pop I believe)
maybe they named it after them?
EDIT sorry for the double post but I'm using my mobile and opera mini sucks ass even tough it's fucking fast
Click to expand...
I suppose, its the same with 2NE1. Theyre korean, i think.
 
ComfortablyNumb95 said:
^^^
you mean 5f pb22? I just smoked it once and as far as I can remember (I may be wrong tho) it was a rather mellow high, almost hash-like.
I kinda.recall it even if I tried it only once because
me and my friend recorded a jam while on it and we called it "5f pb22" what fantasy lol

I'm not sure tough so I'd like to hear somone else's reports

P.S. I just ordered some AM2201 and reports say that it is active at even 500ug is it really that potent? how does ot compare to 5f-akb48?
Click to expand...

Sorry too much of a syncan (love that name) newbie to compare flavours for you. I got my first batch through: akb48, bb22, pb22 one gram of each, and far too much for my needs. The prices for the pure noids were too cheap to resist. Anyway, when they ban these things, it can't hurt to have a stash.I tried smoking an mg or so of bb22 (the only one I've tried) for a very relaxed, hash-like high more physical than mental. Very enjoyable, just like smoking a drag on a decent hash joint, only not so trippy. Them I screwed up and vaped around six mgs, and got the most fucked up I've probably been in my life, almost gave in to the fear, but took 2 mg of intas and staggered into bed like a zombie, heart pounding like a jackhammer, and crashed hard. I'm not touching this stuff until I can make a proper blend; eyeballing too risky. Noids aren't something I'd want to do everyday - I could imagine these things really frying your receptor sites if used too much.

Edit: Oh yeah, the effects lasted far longer than I was expected. The larger dose went on for around 4 hours, and I have a mild but distinct weed hangover today.

I do have a question; if I was gonna make 50 grams of incense/blend, how much acetone would I need to ensure a decent infusion of noid to herbal material? I won't be spraying the herb, but making a kind of acetone bath for it, sprinkling in my noids, and stirring.

One thing I don't get are these 5f varieties that are cropping up; eg 5fpb22, 5fakb48. Are these stronger than the standard noids?
 
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That's great 2 know. Literally haven't heard an exact ratio anywhere; thanks. Are there any other commonly used solvents which dissolve noids btw?

Edit: found a comfortable dose of bb25 and it's mellow, fairly cerebral, only not too trippy and panicky of some others I've heard. I can only compare it to a really clean version of UK soap bar hash, with none of that grotty, headachy feeling. It's strange, but effects have lasted a good 2 hours and going strong. Probably due to the fact I haven't touched any type of cannabis for years, and always did have a lo tolerance.
 
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i prefer using 99% Isopropyl Alcohol over acetone. it takes a bit longer to dry, but seems to make a smoke that is less harsh than acetone.

plus a dude buying rubbing alcohol looks pretty inconspicuous.

the 99% isopropyl is harder to find. i've used 91% in a pinch.... i wouldn't use anything less concentrated than that, though.
 
Yeah something cheap and inconspicuous like rubbing alcohol would be absolutely perfect. I'll check out my local hardware store for sure.

Sorry for the dumb question, but how about that gel alcohol hand wash as used in hospitals; I wonder if that would evaporate. I'm guessing almost certainly not btw.
 
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