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[Mega] Harm protection supplements

levictus said:
Is it safe to take a MAO-B inhibitor with MDMA (Even though Selegine seems pretty tame as far as MAOIs go)? Doesn't that lead to seratonin syndrome? Or is 10-15 mg a safe dose?

L-Tyrosine looks pretty interesting...
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i dont see the big deal in selegiline, i mean if you take a lot of it, it also inhibits MAO-A. and even so it is only reversible inhibition, meaning if there is a higher concentration of serotonin/NE then the selegiline would unbind from the MAO-A.

i never had an issue with selegiline and MDMA my self, you might be different though..

ill just stay with 2.5mg to 5mg per day with food to be safe.
 
Advanc3d said:
Yes long term 5-htp usage depletes Dopamine.

serotonin and dopamine precursors use the same enzymes. and that enzyme is rate limiting.
so when ur taking 5-htp everyday, the enzyme is converting it to serotonin, but that enzyme gets depleted and dopamine's production is inhibited.


the only way to have optimal levels is to take both dopamine and serotonin precursors and not just one.

long term 5-htp usage causes depression and unbalanced neurotransmittor levels.

also, when you take 5-htp, MAO increases to metabolise the excess serotonin, not only does the serotonin get metabolised but so does dopamine and norepinephrine.
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i was taking 5hpt for like month straigth everryday maybe lil longer ..could this be a reason that i cant feel the mdma effects( i am not mdma abuser) n if yes what should i do to get my serotonin n dopamine levels equal?
 
Advanc3d said:
Though the following is for a hardcore night (i.e 4 pills in a night)
so maybe somethings can be cut out but doesnt really hurt.. in this case, more _does_ mean better, but it actually depends.
My Regime

Preload (1 hour before)

2000mg - Vitamin C
2500mg - Acetyl-L-Carnitine
400mg - Alpha Lipoic Acid
500mg - Green Tea extract
1x - Quercetin
4000mg Piracetam


During
2x 300mg Alpha Lipoic Acid


Post
2x 2000mg Vitamin C
2x 400mg Alpha Lipoic Acid
3x 100mg 5-HTP
1x Green Tea Extract
1x Quercetin
400mg Magnesium
3000mg Piracetam
1500mg GABA
9mg Melatonin



p.s when you see "2x" that means like doses a few hours apart
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So how often are you able to roll with no loss of magic, following this regimen?
 
Sounds like aspirin might be worth a try?!

"One novel and unlikely-sounding proposal to minimise MDMA-induced neurotoxicity is pretreatment with aspirin. Aspirin inhibits the enzyme prostaglandin H synthase (PHS). PHS catalyses the transformation of amphetamines into toxic free radical products. Therefore taking aspirin before MDMA use may also indirectly block the conversion of amphetamines into reactive oxygen species responsible for long-term neurotoxicity. As of 2009, no controlled trials of aspirin have yet been conducted with MDMA-using humans. But if aspirin pretreatment does prove an effective harm-reduction strategy, then this is potentially a godsend - not least because other candidate neuroprotectants (SSRIs, selegiline, etc) carry hazards of their own in conjunction with E-use. Aspirin itself cannot strictly be described as risk-free; but the risk/benefit ratio of its use is both favourable and well-known. "

from: http://www.mdma.net/#ecstasyprotect

and

http://www.mdma.net/kobie/simple.html
 
avcpl said:
So how often are you able to roll with no loss of magic, following this regimen?
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the loss of magic has nothing to do with that. well at least from what i theorise

my theory is that the magic has to do with serotonin receptors,
after many rolls, serotonin receptor density decreases and serotonin molecules would not bind completely to receptor sites.

if its permanent, it does not cause any side effect in our general moods because the brain starts producing more serotonin to compensate (to restore equilibrium).

now saying that.
if i go for 6 months without taking pills, if i then wake up one morning and take 100mg of 5-htp i would NOT feel anything at all.
Back in the days when i just began to start taking pills, 100mg of 5-htp would give me some sort of euphoria with a nice brain buzz feeling (the feeling associate with the "magic")
 
Rolki373 said:
i was taking 5hpt for like month straigth everryday maybe lil longer ..could this be a reason that i cant feel the mdma effects( i am not mdma abuser) n if yes what should i do to get my serotonin n dopamine levels equal?
Click to expand...


short answer, stop taking 5-htp and give it a rest for a month until your brain restores equilibrium.
 
oooo it was looooooong time ago like back in march april i havent taken 5hpt since than @ allll
 
Great thread in relation to harm minimisation supplements. Was just wondering whether Quercetin and Piracetam are able to be imported legally in Australia. Found this on another forum:

Just found this on piracetam: http://www.erowid.org/smarts/piracet...tam_law1.shtml

Please note, that after 1 May 2007, the /Standard for the Uniform
Scheduling of Drugs and Poisons/(SUSDP) will place this medication into
Schedule 4 (ie prescription medicine). This means that if the goods are
sent to you after this date, along with the medicines, documentation
(either a copy of the prescription or a letter from an
Australian-registered doctor) which demonstrates clearly that the
medicines have been prescribed to you must be included in the parcel.
This is a legal requirement.

Thoughts?

Also what is your daily supplement regime?
 
I bought myself some Magnesium Chelate. I go home and find out that it also has some Calcium in it too. Is That counter-productive to take? Cus I know calcium promotes nerve firing, whereas magnesium calms it. It seems more ideal to just take the magnesium to give it a better Magnesium:Calcium ratio or whatnot.

Should I just take my magnesium taurate instead? or ZMA..
 
BeenBeaningDFW said:
I bought myself some Magnesium Chelate. I go home and find out that it also has some Calcium in it too. Is That counter-productive to take? Cus I know calcium promotes nerve firing, whereas magnesium calms it. It seems more ideal to just take the magnesium to give it a better Magnesium:Calcium ratio or whatnot.

Should I just take my magnesium taurate instead? or ZMA..
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If two minerals were contraindicated to take together, why would they be put in the same supplement? ;)
Should be fine.
 
What I sincerely believe is that if you take care of the brain and give it what it wants and needs. Keep those nuerotransmitters buzzing on all cylinders you can have fun the rest of your life.
 
If I drink green tea and orange juice all day before and after, and supplement with 5HTP for a few days after - which other supplements do you think I absolutely MUST take for my brain health?

Also, do you think there would be a negative effect on my brain health or my roll from the caffeine and sugar or anything else in the tea or OJ?

I normally take a multivitamin, which includes B6... I read somewhere (and I don't know if this is totally bullshit or what) that B6 and 5HTP shouldn't be taken together because the 5HTP will be metabolized before it can reach your brain. Would you guys recommend holding off on the multivitamin for a few days post-roll while I supplement with 5HTP - or would just taking the multivitamin be better in the long run? I guess 5HTP mostly helps with the come down and not being depressed... but the multivitamin might be better for overall health / recovery?
 
Advanc3d said:
i differ from most people who take mdma, i usually just sit in a corner or on a seat just smacking out while i watch everyone dance around. this usually puts me in some kind of psychedelic half-sleep sorta thing, modafinil/adrafinil seems to stop that from happening
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Why on Earth would you want to prevent that from happening? That's THE experience. Fuck dancing around. No offense, but anyone who uses MDMA simply to dance and fuck and do all other sorts of shit you can do SOBER, you are completely wasting a brilliant substance. Ya'll go to the club, I'll be in galaxies NASA will never discover. Feel free to join me.

Anyway, I thought this was interesting regarding Selegiline:

http://en.wikipedia.org/wiki/Selegiline#L-amphetamine_and_L-methamphetamine
 
Advanc3d said:
also any one thinking about taking L-Tyrosine or L-tryptophan post MDMA. it will not DO ANYTHING!

MDMA usage causes oxidation on the enzymes that convert tyrosine and tryptophan to l-dopa and 5-htp. these enzymes will not work for about a week after mdma usage.

people are advised to take direct precursors of serotonin and dopamine to increase their neurotransmittors. otherwise in that week, serotonin and dopamine levels can drop upto 40% since our body can not synthasis the neurotransmittors from food sources
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Yeah, why stop for gas? Your tank is empty, you're not going anywhere.

I get your point though; there are better ways.
 
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