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[Mega] Harm protection supplements

topgunner19 said:
thank u Advance!!!! wicked information,, how do you keep trk of all the supps,,, how do you take them all,,
i tried the paracetam,, a bit of preload 5htp,,, is the ALA really better before,, during, and after??
if a newbie, or rookie were reading all this,, what would be,, say the top 3 or 4 most important, best bang for buck, must haves,,,,, ?? say like 1 to 4,,,
fascinating!! its pure science
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I pretty much mix my own ratios in to capsules and prepare my self pre and post loading stacks.

i put them in seperate ziplock bags and mark the capsules with a nontoxic marker on what it contains and take them accordingly..

i would say the main supplements to take would be;

1. Alpha Liopic Acid combined with Vitamin C. This is pretty good for before during and after. though studies show neurotoxicity really happens after but better be safe then sorry i guess.

2. Some sort of MAO-B inhibitor (cat's claw, Quercetin, or once off dose of 10-15mg of Deprenyl 3 hours before MDMA, this seems to effectively attentuate about 90% of neurotoxicity. i never had a problem with a high dose of deprenyl if its only once off, meaning its okay to take 15mg before mdma without inhibiting MAO-A if taken 3 weeks apart)

3. Piracetam

4. 5-HTP
 
Euphenomenologist said:
Everyone should check out Life-Extension supplements, especially their state-of-the-art multi-vitamin-mineral mix: www.lef.org :)
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you mean their state of the art pricing also?

multivitamins of that kind, to my opinion is really not necessary unless you have some sorta OCD that compels you to use it



I've taken a picture of all my supplements lined up > click the link for full size picture

http://img177.imageshack.us/img177/208/supplements.jpg

supplements.jpg
 
Advanced, or anyone else who has an interest, is this ready to be archived for posterity or does it still require work?
 
Well is there a supplement solution to cause faster replenishment of cell surface 5-HTRs yet? If not, then no it is not done. However it might not be 20 years before this happens...
 
Is imageshack a stable long-term image hosting provider? Or will they delete that image long before people stop reading this thread?
 
Will these supplements help prevent the loss of the "magic?" Or is that the type of thing that only extended breaks can bring back?
 
would anybody know about using vitamin B's (i.e B12 or a complex) to 1) help cell production, 2) improve memory (seeing as this is one of the key areas affected by MDMA usage) and 3) increase energy levels (post-usage)? Just wondering if anyone has any experience with these as they are said to help improve mental clarity..

also, what about use of st. johns wort (post-usage or continuous) to help with maintaining mood?
 
MazDan said:
Advanced, or anyone else who has an interest, is this ready to be archived for posterity or does it still require work?
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well its pretty much done unless i read up about something, read in to it and find it useful for this thread.
and im sure people are still going to ask questions, but who knows.
you can achieve it if you want?
 
Thanatos_Nyx said:
would anybody know about using vitamin B's (i.e B12 or a complex) to 1) help cell production, 2) improve memory (seeing as this is one of the key areas affected by MDMA usage) and 3) increase energy levels (post-usage)? Just wondering if anyone has any experience with these as they are said to help improve mental clarity..

also, what about use of st. johns wort (post-usage or continuous) to help with maintaining mood?
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Well from what i have been told,

in general B vitamins are good for cell maintenance and what not, but to what extent to someone who takes drugs.. im not to sure.

Though i can break down what B vitamins do..

in general speaking they all have a part in amino acid / carbohydrate metabolism (i.e energy prouction.. ATP production), building blocks of neurotransmitters.
hence why they are pretty essential and found nearly in all foods.

But stuff like Methylated B12 would be useful in nerve regeneration, though whether that property is because of the combination of B12 and a methyl group attached, or sorely because its a Methyl donor..

From my understanding, Methyl donors are important, and we are depleted in such levels during stressful times, particularly mental stress rather than physical stress.

Studies show that people who consume methyl donors regularly, whether its Methyl-B12, Dimethylglycine, Trimethylglycine, Methyl-Folate or what ever have increased neurotransmitters, not to mention methyl donors are also an alternative to antidepressants



I personally wouldn't touch SSRI's, i don't know to much about st. johns wort, but if it has the same properties as prescription grade SSRI's then i wouldn't want to have long term sexual dysfunction after coming off, as well long term downregulation of serotonin receptors.
 
topofthetrees said:
Will these supplements help prevent the loss of the "magic?" Or is that the type of thing that only extended breaks can bring back?
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Well no one knows why "loss of magic" happens.. chemically speaking.
But the only thing that makes sense to me is that is caused from sensitization, down regulation, and also increased inactivity of some of the subtypes of serotonin receptors after being over used by serotonergic drugs, Theoretically speaking with time things should return back to normal in terms of gaining the magic back. but that is if you dont take drugs in total.


An interesting read i had the other day, which i don't have the source at the moment that... Inositol (listed on front page of this thread) aids in desensitization of serotonin receptors, which is why its also an alternative to antidepessants at dosage over 10g a day as well as a cure to withdrawal effects from SSRI's
 
I'm curious about your opinion on vitamin C. I read a post of yours on M&M that said that preloading with vitamin C cuts your roll in half. But then, you recommend here to preload with vitamin C. What's your updated/final opinion now?

Also, one more question: if I'm taking the supplements that you recommend, since some of them potentiate MDMA, should I cut back on my MDMA dose? I usually drop 2 pills at the start so I don't have to keep redosing later (which I read is quite harmful - do you agree?); should I cut back since I'll be potentiating the roll with quercetin/piracetam, etc?
 
hi Advanc3d,
i just bought sleepasil, http://www.sleepasil.com/ and i'm adding it to my pre/post load regimen.
The contents section of the site says it contains 3mg melatonin, 30mg magnesium oxide and 40mg calcium carbonate. There are other stuff like valerian root, hops and stuff but this is my main concern/query:
3g Melatonin is to be administered sublingually post usage while magnesium is to be taken before dropping to help with the clenching. Obviously, there's no way for me to separate the contents of the supplement capsule.
Based on the contents and your knowledge on this matter (lol, i sound too formal), do you think i should take it as a pre/post load supplement?
I also read somewhere that calcium increases clenching, which is another factor that's confusing me with regards to taking this pre/post usage.
Any info from you or from other BLr's would be greatly appreciated.
Thanks in advance... High five guys!
 
I went through the medical literature on pubmed and others and made a list of all the compounds that have successfully reduced brain damage in mice when given in conjunction with MDMA.

L-Deprenyl is the most important, I think--it prevents the metabolism of dopamine, which is where you get all those nasty peroxides. The rest are powerful antioxidants that have been shown to greatly mitigate MDMA's destructive effects on mitochondria in mice.

Here are some of the studies:

Selegeline / L-Deprenyl: Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria.

ALCAR: Acetyl-L-carnitine provides effective in vivo neuroprotection over 3,4-methylenedioximethamphetamine-induced mitochondrial neurotoxicity in the adolescent rat brain.

Alpha Lipoic Acid: Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced neurotoxicity.
 
Outside of 5-htp, which supplements would you guys say are most important? (and that I can buy at cvs) I already have magnesium and 5htp. I'm thinking piracetam, green tea extract, and vitamin c would be good.

I'd rather not spend $100 at cvs buying every supplement, ha.
 
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I'd say ALA and Acetyl-L-carnitine, after all, prevention is better than cure.
 
Hm do any local stores even sell piracetam? It's not on the website of cvs or the vitamin shop.
 
Prea said:
Hm do any local stores even sell piracetam? It's not on the website of cvs or the vitamin shop.
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very doubtful... you can get it on the bodybuilding.com store or cognitivenutrition.com (not sure if im allowed to link sites but oh well), but it'll cost you.
 
tizim said:
I'm curious about your opinion on vitamin C. I read a post of yours on M&M that said that preloading with vitamin C cuts your roll in half. But then, you recommend here to preload with vitamin C. What's your updated/final opinion now?

Also, one more question: if I'm taking the supplements that you recommend, since some of them potentiate MDMA, should I cut back on my MDMA dose? I usually drop 2 pills at the start so I don't have to keep redosing later (which I read is quite harmful - do you agree?); should I cut back since I'll be potentiating the roll with quercetin/piracetam, etc?
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I replied to your post on Mindandmuscle,
I think in that post i advised that Ascorbic acid would lower pH, where as bufferd Vitamin c, i.e ascorbate salts would not.

Though Ascorbyl Palmitate would be far superior then normal vitamin C, as its fat soluble
 
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