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[Mega] Harm protection supplements

Whacked_Out said:
hi Advanc3d,
i just bought sleepasil, http://www.sleepasil.com/ and i'm adding it to my pre/post load regimen.
The contents section of the site says it contains 3mg melatonin, 30mg magnesium oxide and 40mg calcium carbonate. There are other stuff like valerian root, hops and stuff but this is my main concern/query:
3g Melatonin is to be administered sublingually post usage while magnesium is to be taken before dropping to help with the clenching. Obviously, there's no way for me to separate the contents of the supplement capsule.
Based on the contents and your knowledge on this matter (lol, i sound too formal), do you think i should take it as a pre/post load supplement?
I also read somewhere that calcium increases clenching, which is another factor that's confusing me with regards to taking this pre/post usage.
Any info from you or from other BLr's would be greatly appreciated.
Thanks in advance... High five guys!
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Well Magnesium has the lowest bioavailability of all magnesium compounds.
At 30mg, you will probably absorb <5% of that amount.

I dont know the exact reason why calcium would "increase" clenching, but Calcium and Magnesium seem to compete in the cell membrane, I mean, Mg2+ and Ca2+ ions,
Magnesium would be "calming" or "inhibitory", and Calcium would act as "excitatory" i.e increase neurotransmission. anyway that said, calcium in theory would increase neurotoxicity via Glutamate receptors (NMDA), but whether this would be the case in the human body is a good question.


Prea said:
Hm do any local stores even sell piracetam? It's not on the website of cvs or the vitamin shop.
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This is not over the counter
Most suppliers do not sell piracetam anymore for what evr the reason may be, including BN, NP and BAC
 
woah nice!!!!!!
good job with the report
gonna get myself some taurine and pirracetam :]
 
What up all! This question may be dumb, but since there is so much good info here it is really hard to disseminate what is best for your roll. I am 5'6", 200 pounds (stalky I know) and only roll about every 2 months. So I've got the fact that I should load up on 5-htp a few days before but not on the day of and then a few days after. I also see that Magnesium is good too. My question then is this, what else is recommended and easily accessible via drug / nutrition stores? Thanks.
 
Has anyone heard of using "Chlorpheniramine" after like 3 hours of taking MDMA to block most of the damage caused by MDMA? Has anyone tried this? It sounds like a very helpful supplement to take after rolling, but I just want to know a little more about it.


I read about this in the Advanced Drug Discussion:
"You can, however, use the antihistamine chlorpheniramine to protect against the damage. Chlorpheniramine is a potent and long-lasting (24h+) serotonin reuptake inhibitor. It was shown in rat studies to completely block the damage induced by MDMA just like the SSRIs. Better yet, it's available almost everywhere over-the-counter for cheap. I'm not exactly sure what dose to recommend you but I'm guessing somewhere around 50-100 mg. Here's some more information:

* http://en.wikipedia.org/wiki/User:Ro...lorpheniramine
* http://www.ncbi.nlm.nih.gov/pubmed/10420168

Also I'd recommend you dose 3 hours in as opposed to 6 hours. In other studies it has been shown that dosing 3 hours in completely blocks the damage, whereas dosing 6 hours in only partially blocks it."
 
Hey, just found this bit of info:
"N-Acetyl Carnitine (NAC) is a more bioavailable form of L-carnitine. As a result, it is absorbed into the bloodstream more efficiently than L-carnitine, passes more effectively through cell membranes, and is more readily utilised in the mitochondria of cells."

Would this therefore be good to use if it was the only carnitine available? Do you guys agree it would be better?
 
rokinrollin said:
What up all! This question may be dumb, but since there is so much good info here it is really hard to disseminate what is best for your roll. I am 5'6", 200 pounds (stalky I know) and only roll about every 2 months. So I've got the fact that I should load up on 5-htp a few days before but not on the day of and then a few days after. I also see that Magnesium is good too. My question then is this, what else is recommended and easily accessible via drug / nutrition stores? Thanks.
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I posted my recommended pre and post loading a few pages back

Note, It is not recommended to pre load with 5-htp
Doing so would shorten your roll.
Supplementing with any neurotransmitter precursors will down regulate your receptors (i.e makes it seem as though you have a tolerance).
 
Clean_Cut said:
Hey, just found this bit of info:
"N-Acetyl Carnitine (NAC) is a more bioavailable form of L-carnitine. As a result, it is absorbed into the bloodstream more efficiently than L-carnitine, passes more effectively through cell membranes, and is more readily utilised in the mitochondria of cells."

Would this therefore be good to use if it was the only carnitine available? Do you guys agree it would be better?
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I and others have posted about this in this thread..

Acetyl-l-carnitine has different properties than L-Carnitine alone.. even though its the identical amino acid except with a acetyl group attached to the molecule.
So this would be far more superior then regular l-carnitine.

I would say, Acetyl-l-Carnitine Arginate > Acetyl-l-Carnitine > l-carnitine
for more potent to less potent

Acetyl-l-carnitine it self isnt expensive at all,
Last week my order of 100grams came for $15 USD
 
I love this thread - it really is one of the best in the ED.
Does it not sum up what this whole site should be about?
My supplement army now consists of:
Alcar
Alpha Lipoic
Vit C, B, E
Fish Oil
Green Tea Extract
Magnesium
Gingko

Definetly worth the money to have the peace of mind so that on the occasion I do roll, harm is being minimised.
 
This is an absolutely awesome thread, some great information here.

Although I'm surprised not to see St. John's Wort mentioned?
 
Advanc3d said:
supplements.jpg
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What are you using the Olmifon / adrafinil for?
 
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Advanc3d has a box of adrafinil/olmifon in his supplements picture, but doesn't mention it in the thread. I wouldn't really consider it a supplement, its a stimulant and wakefulness promoting agent albeit with a different mechanism from amphetamines. I've taken it with mdma and found that it prevents me from feeling as floored and floaty, but also feels like I don't have as strong a euphoric or empathetic experience (perhaps because I don't feel as floored.) I don't really like it as a roll add-on for that reason, so I was wondering what value Advanc3d felt it had.
 
blue_locus said:
What are you using the Olmifon / adrafinil for?
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i go to uni so i use it for concentration and what not. but im switching to modafinil soon..
and i differ from most people who take mdma, i usually just sit in a corner or on a seat just smacking out while i watch everyone dance around. this usually puts me in some kind of psychedelic half-sleep sorta thing, modafinil/adrafinil seems to stop that from happening
 
Great info! Just have a couple questions:

1.) The studies that you posted on Acetyl-L-Carnitine, Alpha Lipoic Acid, and Deprenyl all show harm reduction when taken 30 minutes before MDMA? I'm just wondering are all of these supplments safe to take with MDMA, and can they be taken on an empty stomach?

2.) Are most of these supplements that you listed safe to take for an extended period of time, say like a month before rolling? I've heard mixed things about taking 5-HTP and L-Tryptophan for long periods of time.

Thanks ;)
 
DaftPunkFan said:
Great info! Just have a couple questions:

1.) The studies that you posted on Acetyl-L-Carnitine, Alpha Lipoic Acid, and Deprenyl all show harm reduction when taken 30 minutes before MDMA? I'm just wondering are all of these supplments safe to take with MDMA, and can they be taken on an empty stomach?

2.) Are most of these supplements that you listed safe to take for an extended period of time, say like a month before rolling? I've heard mixed things about taking 5-HTP and L-Tryptophan for long periods of time.

Thanks ;)
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Alpha Lipoic acid would need to be taken anywhere earlier then 30min before. and also considering neurotoxicity kicks in more so towards the end of the roll and for 48 hours after, that would be more of a important time to consume antioxidants.

With Deprenyl, if taken with food it hard a lot more bioavailablity, where taken on an empty stomach it isnt absorbed much, i usually take deprenyl everyday at 2.5mg (With food) and considering its a irreversible mao-b inhibitor, it wouldnt matter when you have it.. but i my self no longer take deprenyl because it doesnt effect me right, makes me feel retarded and sleepy all the time.

Acetyl-L-Carnitine should be taken 30min before :)

i personally see no use in taking Tryptophan if you can get 5-htp, only because tryptophan hydroxylase enzyme (enzyme that converts tryptophan to 5-htp in the body) is destroyed and does not return back to normal for a few days. 5-htp should be taken on a empty stomach but not for long periods of time. as taking it frequently would cause you to have a tolerance to pills (excess serotonin would raise MAO, MAO selectively metabolises serotonin/noradrenaline, therefore it would put your serotonin/noradrenaline levels out of balance, and not only that, for your brain to keep an equilibrium, excess serotonin would cause down regulation of serotonin receptors which is one of the main reasons for tolerance)
 
Advanc3d said:
Alpha Lipoic acid would need to be taken anywhere earlier then 30min before. and also considering neurotoxicity kicks in more so towards the end of the roll and for 48 hours after, that would be more of a important time to consume antioxidants.

With Deprenyl, if taken with food it hard a lot more bioavailablity, where taken on an empty stomach it isnt absorbed much, i usually take deprenyl everyday at 2.5mg (With food) and considering its a irreversible mao-b inhibitor, it wouldnt matter when you have it.. but i my self no longer take deprenyl because it doesnt effect me right, makes me feel retarded and sleepy all the time.

Acetyl-L-Carnitine should be taken 30min before :)
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Ok thanks a lot, so the antioxidants would work best if taken after rolling, like the green tea extract and such?

One more thing, would you recommend taking a few of the supplements like L-Theanine for a while before rolling to build it up, or just take it before/after rolling? Thanks again for the info
 
L-tyrosine and L-tryptophan are also good ones.

Tyrosine helps replenish dopamine and norepinepherine (sp?) and tryptophan helps with seratonin.
 
Advanc3d;7038755 2. Some sort of MAO-B inhibitor (cat's claw said:
once off [/B]dose of 10-15mg of Deprenyl 3 hours before MDMA, this seems to effectively attentuate about 90% of neurotoxicity. i never had a problem with a high dose of deprenyl if its only once off, meaning its okay to take 15mg before mdma without inhibiting MAO-A if taken 3 weeks apart)
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Is it safe to take a MAO-B inhibitor with MDMA (Even though Selegine seems pretty tame as far as MAOIs go)? Doesn't that lead to seratonin syndrome? Or is 10-15 mg a safe dose?

L-Tyrosine looks pretty interesting...
 
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