Scheduling another compound is the last thing we need. Yes, it is largely the profiteers of these mass produced formulations who are responsible for getting it into the hands of people who probably are not fit to be drinking coffee.
And yes while technically speaking, compared to cocaine, MDPV has a lower Ki value at the DAT (i.e. it has higher affinity), which explains the desire to self-administer, but it has nowhere near the affinity for the SERT. It does have some however, but in very disproportionate ratio to the DAT/NET, whereas cocaine is a very "balanced" reuptake inhibitor of the DA/NE/5-HT. I believe in self-administration studies, blockade of the cocaine's 5-HT reuptake inhibition DID reduce self-administration. But certainly, (as we can see with d-methylphenidate, a potent DA/NE reuptake inhibitor with no affinity for the SERT), that compounds like MDPV can elicit great desire to re-dose.....but it does not beat cocaine in self-administration/reinforcing properties. And qualitatively, in humans, cocaine will be chosen over a compound like d-MPH. However, d-MPH can pretty effectively substitute for cocaine in cocaine-trained laboratory animals, but then again, i believe cocaine-trained rats will self-administer magnesium chloride in the presence of cocaine, but is a poor substitute (don't try snorting magnesium chloride......i bet it hurts)......
Point is, just because you feel the need to reuse it doesn't truly make it more "addictive".......D-MPH when inhaled will provoke the need to reuse, but in humans does not have the same abuse potential as cocaine. Same as the case of MDPV......if you try to substitute MDPV to cocaine-trained humans (colloquially, "crack-heads") you will probably get stabbed.....
And yes while technically speaking, compared to cocaine, MDPV has a lower Ki value at the DAT (i.e. it has higher affinity), which explains the desire to self-administer, but it has nowhere near the affinity for the SERT. It does have some however, but in very disproportionate ratio to the DAT/NET, whereas cocaine is a very "balanced" reuptake inhibitor of the DA/NE/5-HT. I believe in self-administration studies, blockade of the cocaine's 5-HT reuptake inhibition DID reduce self-administration. But certainly, (as we can see with d-methylphenidate, a potent DA/NE reuptake inhibitor with no affinity for the SERT), that compounds like MDPV can elicit great desire to re-dose.....but it does not beat cocaine in self-administration/reinforcing properties. And qualitatively, in humans, cocaine will be chosen over a compound like d-MPH. However, d-MPH can pretty effectively substitute for cocaine in cocaine-trained laboratory animals, but then again, i believe cocaine-trained rats will self-administer magnesium chloride in the presence of cocaine, but is a poor substitute (don't try snorting magnesium chloride......i bet it hurts)......
Point is, just because you feel the need to reuse it doesn't truly make it more "addictive".......D-MPH when inhaled will provoke the need to reuse, but in humans does not have the same abuse potential as cocaine. Same as the case of MDPV......if you try to substitute MDPV to cocaine-trained humans (colloquially, "crack-heads") you will probably get stabbed.....