Jabberwocky
Frumious Bandersnatch
I was just doing some personal research, regarding epinephrine.Vit C pills are good but there was just something to the infusions where I felt refreshed. I'm sure part of it is placebo but the blood levels you get with IV are much higher. Vit C is pretty good for the HPA axis too.
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A single administration of ascorbic acid rapidly reverses depressive-like behavior and hippocampal synaptic dysfunction induced by corticosterone in mice
Ketamine is the prototype for glutamate-based fast-acting antidepressants. The establishment of ketamine-like drugs is still a challenge and ascorbic …www.sciencedirect.com
Another thing I think which predisposes one to HPA or neurosteroid issues is low cholesterol. My chol levels were always very low like 100, so something like MDMA could easily mess up the steroid cascade and neurosteroids too. I wonder what the chol levels are of the LTC sufferers
Also I tried AlloPregnanolone drops recently for my caffeine blunting issue and they were amazing temporarily. The first time it felt almost like MDMA itself, so I think there’s a connection and its not serotonin.
Amazingly epinephrine, norepinephrine, adrenaline, noradrenaline all cause massive loss of magnesium in the body.
MDMA and other stimulants cause significant release and reuptake inhibition of norepinephrine.
Perhaps loss of magnesium due to abuse of MDMA and stimulants is the causative factor or a major causative factor of LTC.
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