Phenethylamines Low Dose Mescaline

[placebonaut]

Sensitivity meaning physically?

nerve stimulation, the higher the dose with me the more it feels like my body is being shocked with electricity!

2C-B does not form tolerance,

hmm I thought it did slowly with repeated use, especially when doing it close together, thought I'd read about that somewhere and psy wiki has a pretty vague 1 liner on it.

2C-B

4-Bromo-2,5-dimethoxyphenethylamine (also known as Nexus, Bromo Mescaline, BDMPEA, Venus, and 2C-B) is a novel psychedelic substance of the phenethylamine class. It is perhaps the most well-known member of the 2C-x family, which are structurally related to the classical psychedelic mescaline...

psychonautwiki.org

"Tolerance to the effects of 2C-B is not built almost immediately after ingestion. There are many anecdotal reports of people ingesting this substance many days in a row (either consecutively or by redosing many many times in a row and tripping continuously for dozens of hours) with no immediate tolerance build up and still building quite slowly even under sustained exposure."

I was getting the same exact mood boosting energizing effects from 4mg orally and visuals from 7mg orally throughout this entire period of daily use, the same period where that line of roughly a point of 2C-B put me in a phenethylamine-tinged breakthrough akin to what DMT or DPT can do. I just gave that line the fucking Hoover man, the Dyson, the Shark, I simply hit that bitch like a vacuum cleaner with a job to get done, haste in my heart and vigor in my veins. That shit permanently changed me as a person, dramatically reoriented me towards focusing on making music with my life, on top of the usual chemistry and skateboarding.

I'm not getting anything near that with ~30mg, sounds amazing, would love too but the nerve effect is pretty intense so concerned about handling if it I push it harder

 

[Didgital]

Hey so... I posted a bit back about microdosing mescaline before work.. I didn't really measure the dose. What do yall think is a good functional mini dose if I wanted to do it before sayyyyy going to work? If I had to guess I'd say I took 30-50mg but not sure. It was great! I do not want to overdo it tho..

I might start doing it more often and wanted to get some advice from people who have more experience doing it than myself.

In mexico when I was in the Wirikuta desert on a peyote pilgrimage, on the way back someone had cut a rather large button and no one wanted it. I didn't want it to go to waste so I ate it before the trek back to civilization. It was better than coffee and gave me good clean energy. I'd also met an 80 year old mexican lady who told me her husband would eat a single button every day, no alcohol, no tobacco, nothing else and he lived to 100. I'd asked her what she thought about gringos coming to the desert and if it was ok for me to eat them. She told me it is medicine for anyone who it calls to.

 

[iom]

Shulgin lists a mescaline dose range of 200-400mg for the "sulfate salt". Going by my 1/6th rule to get to a "one beer" level of intoxication, we arrive at 33 mg. Hence 30-50 mg sounds entirely reasonable to me. Of course all I've had were cacti, so I don't really have a personal basis for recommending doses.

As for doing it at work, I think that would depend a lot on the type of work. I think it would be better with work that is mostly physical and/or in a natural outdoor environment such as gardening or landscaping. If I were a farmer then I think that "one peyote button a day" prescription could be quite nice. Otherwise though, I usually prefer sobriety at work. I don't even use caffeine because my body is hypersensitive to it.

 

[xdrc]

I have no advice to give but am eager to hear about which dose you will settle on and what you think about it. Personally I would not go to work on anything beyond caffeine, but you know yourself and your circumstances better than I. Are you trying to go for the stimulant effect or a little beyond that?

Also thanks for that anecdote!

 

[doubledog]

I am also interested in microdosing mescaline (or minidosing as I expect to feel some effects).
Would start with 30mg.

 

[realgar]

Hey so... I posted a bit back about microdosing mescaline before work.. I didn't really measure the dose. What do yall think is a good functional mini dose if I wanted to do it before sayyyyy going to work? If I had to guess I'd say I took 30-50mg but not sure. It was great! I do not want to overdo it tho..

If you are sensitive to mescaline (like me decades ago), I'd suggest 15-30 mg. A higher dose, like 50-60 mg, would interfere with daily activities (again, for a sensitive person).

 

[red22]

They are also not entirely reliable in inducing the entactogenic state

I've never gotten even a slight mood boost from a phenethylamine psychedelic. But I know other people do—it's cuz I'm severely depressed, but my experience still shows just how weak their mood elevation is.

 

[Allylbenzene]

If you are sensitive to mescaline (like me decades ago), I'd suggest 15-30 mg.

I think most people in this thread overlook the influence of enzymes in dictating sensitivity to mescaline. Putting aside MAO, the more relevant enzyme appears to be ALDH (aldehyde dehydrogenase). We frequently ingest things which induce & inhibit ALDH, but inducers are far more common (eg sulforaphane: cruciferous vegetables). Inducers provoke greater tolerance, meaning larger doses are necessary.

In contrast, ALDH inhibitors appear to reduce subjective tolerance implying mescaline dose ranges are lowered significantly. This implies 80-100 mg can plausibly produce a strong experience (under ideal conditions). A microdose range would match what you wrote 15-30 mg.

ALDH is automatically regulated, but if someone unknowingly ingests ALDH inhibitors they would be lucky to discover that 80-100 mg mescaline is equivalent to a strong dose.

 

[Didgital]

If you are sensitive to mescaline (like me decades ago), I'd suggest 15-30 mg. A higher dose, like 50-60 mg, would interfere with daily activities (again, for a sensitive person).

I am sensitive. I guess ima go w 30mg.

Also thanks for that anecdote!

here's another.

I was 19 at the time, living in an apartment above the pizza place I worked at. I had just eaten 50g of weak san pedro powder. All of a sudden I hear a knock on my back door. It's the manager.

"Didgital!! so and so didn't show up to work today, can you help us get through the rush"

I stupidly said yes. Umm i remember tripping somewhat hard and also digesting all that powder. In that case I really regretted it because the rush lasted for 8 hours and I was in a hot sweaty tense environment. When I finally got off, I was like... that was a waste of a spiritual experience. |

At that time, mescaline was rare to me.

 

[kinkyjohn]

I remember taking mescaline from cacti and it was low dose central until I nailed the extraction. I think the doses were more of the order of 20-40mg, but basically it was a load of plant chod that was fing disgusting and the feeling sick from eating snot kinda dominated the experience. Not being properly high was also quite annoying .. but then I guess that's the point with microdosing.

I aways found low dose mescaline not having that much to it .. unlike LSD. More like a hard glow as opposed to the (LSD) soft glow. Though it's way more dependable than something like 2cb which whilst it's a wonderful drug one day can be an awful one the next and that's also true of microdosing. And don't even get me started on NbomE.

Best to stick to the well troden path. Microdosing mescaline seems somewhat odd .. though I guess that's probably framed by the fact it was always really hard and expensive to acquire so I'd always make a proper go of it if I was going that way.

 

[Didgital]

though I guess that's probably framed by the fact it was always really hard and expensive to acquire so I'd always make a proper go of it if I was going that way.

I promise that changes when you have a lifetime supply.

 

[iom]

I promise that changes when you have a lifetime supply.

How was your 30 mg trial?

 

[Didgital]

How was your 30 mg trial?

Havent properly done it yet. You know ill report when i get to it. Just took the THP last night and woke up touch groggy and insome what of a rush to get to work.

Ill do this. Ill weight out 20mg tn and tomorrow ill check it out if i remember as im running out the door.

My life is entirely consumed by work lately. Not bad but every free day i have now, i absolutely cherish

 

[Didgital]

So I actually never measured, but this morning I took a knife and took prolly 15mg and waited 45 min with no effect. Then right before i left for work I took another 15mg (approx).

I don't know... I'm definitely in a good mood but if I do feel it it's so subtle that I can barely notice. I'm sure I feel it, cuz otherwise I would feel hungover and like not great.

 

[iom]

So I guess 30 mg is a bare threshold for you, essentially a +/-? I was a bit surprised to see the PIHKAL dose range of 200-400 mg. For some reason, I thought it would be more like 250-450, for which the "1/6th rule" dose would be closer to 40 mg. For you that might be the difference between a +/- and a proper +.

It's funny I should care so much about these numbers being I've never taken a measured dose of mescaline. My first proper cactus trip on my preferred dry material was with 45g, and based on the experience and the many reports I'd read, I assumed what I had was equivalent to "375 mg" mescaline. That and future doses with the same material essentially established my basis. About 2.5 years ago, a "1/6th dose" of 5g was clearly active at a +1 level.

 

[Allylbenzene]

I was a bit surprised to see the PIHKAL dose range of 200-400 mg. For some reason, I thought it would be more like 250-450

Shulgin overlooked the enzyme influence in dictating dose sensitivity. He assumed MAO was relevant when we now know it isn't. Hopefully we'll see proper mescaline resesrch measuring HTR with ALDH inhibitors.

 

[iom]

Yesterday, I took 16 mg mescaline (hemisulfate). Starting at around 15 minutes later, I felt a mood lift and slight increase in aesthetic appreciation, which persisted through the day and into today. I would call this a +/- on the Shulgin scale. Despite no clearly discernible course of effects, I feel just a little bit of afterglow and am noting some slight color enhancement and other sensory enhancements not dissimilar to what I experience after cacti.

I think 16 mg is probably a good starting point for a microdose, for those who like that sort of thing. I plan to take a mini dose somewhere in the 30-50 mg range some time soon.

 

[Esperighanto]

Yesterday, I took 16 mg mescaline (hemisulfate). Starting at around 15 minutes later, I felt a mood lift and slight increase in aesthetic appreciation, which persisted through the day and into today. I would call this a +/- on the Shulgin scale. Despite no clearly discernible course of effects, I feel just a little bit of afterglow and am noting some slight color enhancement and other sensory enhancements not dissimilar to what I experience after cacti.

I think 16 mg is probably a good starting point for a microdose, for those who like that sort of thing. I plan to take a mini dose somewhere in the 30-50 mg range some time soon.

Notorious hardhead here but 75mg was the lowest I could get anything noticeable from hemisulphate, the dose response curve is fascinating though. 75 Is roughly threshold for me, 150 is a moderate dose, 300mg now is a full dose, and 525mg was an absolutely monstrous amount.

 

[iom]

Notorious hardhead here but 75mg was the lowest I could get anything noticeable from hemisulphate, the dose response curve is fascinating though. 75 Is roughly threshold for me, 150 is a moderate dose, 300mg now is a full dose, and 525mg was an absolutely monstrous amount.

Did you try smoking a bunch of weed?

I did a trial with 32 mg mescaline hemisulphate today. It was definitely active for me at this level, but only just. I did some weight lifting right after dosing. Alerts were felt right after the exercise at 20 minutes. At around 1 hour, I started eating a large meal. I was starting to feel jittery, and my appetite was notably suppressed. I finished eating ok. By T+1:30 I was feeling hints of serotonergic activity along with more stimulation.

At T+2:00 I smoked some weed and I drove my partner and a friend out for a hike. The synergy with the weed surprised me, and I felt a little nervous on the road until we got out of the city. Color enhancement was quite pronounced until the weed effects faded. It's hard to say when the mescaline peaked given the synergy with the weed, but the effects didn't really seem stronger at T+4 hours versus T+2 hours. The drive back was smooth and comfortable, and we got home again at around T+6:00. Smoking more weed brought out a little more trippiness for a time. It's T+10:00 now, and the lingering effects are even more subtle.

Major effects noted were: stimulation, feeling of warmth, playful mood with increased propensity to giggle and laugh, increased tendency to yawn and sigh (both of which felt notably relaxing and pleasant), and some slight tactile enhancement.

Comparing to my other psychedelic experiences, this is more similar to my "fast" cacti (T. Terscheckii) than anything else. I'm not confident I can differentiate them qualitatively at this dose, but the time course may be faster with the synthetic. Both feel quite stimulating to me, but the pure synthetic stuff might be a wee bit more so? (That's saying a lot!) And maybe the synthetic offers more color enhancement, but I know that tends to vary a lot between trips anyway. Higher doses should reveal more.

For a low level mini dose, I think I'll opt for a bit more next time like 40-45 mg. However, I'm also looking forward to trying larger mini doses (like 70-80 mg range) as well as having full trips.

 

[Allylbenzene]

My husband and I have been cautiously intrigued by its potential as a replacement for MDMA. There's no shortage of cacti growing around our property, I believe we may have found a lovely winter project.

It's rarely discussed but there's also a role for diet which can influence the nature of the mescaline effects. Essentially (according to my heterodox interpretation) it's possible to achieve a stronger better quality experience from very low doses (50-200mg).

The main idea is to avoid things that increase the activity of the enzyme ALDH (aldehyde dehydrogenase). Here's a fairly comprehensive list of these things:

• cruciferous vegetables (eg broccoli, broccoli sprouts)
• supplements containing taurine, lipoic acid (ALA), sulforaphane, vitamin B5 (pantethine), vitamin B6 (pyridoxine), N-acetylcysteine (NAC), resveratrol, turmeric/curcumin, glucosamine, carnosine, dihydromyricetin, ALCAR, CoQ10
• Fish oil; Vegetable oils (eg sunflower, canola, corn, peanut, soy, cottonseed, rice bran, flax)

Adding things which temporarily inhibit (reduce) ALDH is also beneficial. Pomegranate, lemon juice & OJ are probably the easiest, other items may be used as "add-ons":

• pomegranate juice/extract (ref)
• peppermint/menthol (ref)
• lemon juice (ref)
• quercetin (ref)
• garlic (via allicin)
• durian (ref)
• very low-dose aspirin (62-73% efficacy)
• salicylate (fruit & veg, ref)
• cloves, mace, ginger, fenugreek seeds (ref)
• apple, mango, watermelon, papaya (potency: 76%, 62%, 57%, 50%)
• yellow lemon, blackcurrant, dragonfruit, starfruit, chinese quince, wax apple (ref)
• water chestnut juice, jasmine tea, fresh orange juice (ref)
• plum juice (ref)

Ideally don't combine this with alcohol!