Phenethylamines Low Dose Mescaline

[placebonaut]

Sensitivity meaning physically?

nerve stimulation, the higher the dose with me the more it feels like my body is being shocked with electricity!

2C-B does not form tolerance,

hmm I thought it did slowly with repeated use, especially when doing it close together, thought I'd read about that somewhere and psy wiki has a pretty vague 1 liner on it.

2C-B

4-Bromo-2,5-dimethoxyphenethylamine (also known as Nexus, Bromo Mescaline, BDMPEA, Venus, and 2C-B) is a novel psychedelic substance of the phenethylamine class. It is perhaps the most well-known member of the 2C-x family, which are structurally related to the classical psychedelic mescaline...

psychonautwiki.org

"Tolerance to the effects of 2C-B is not built almost immediately after ingestion. There are many anecdotal reports of people ingesting this substance many days in a row (either consecutively or by redosing many many times in a row and tripping continuously for dozens of hours) with no immediate tolerance build up and still building quite slowly even under sustained exposure."

I was getting the same exact mood boosting energizing effects from 4mg orally and visuals from 7mg orally throughout this entire period of daily use, the same period where that line of roughly a point of 2C-B put me in a phenethylamine-tinged breakthrough akin to what DMT or DPT can do. I just gave that line the fucking Hoover man, the Dyson, the Shark, I simply hit that bitch like a vacuum cleaner with a job to get done, haste in my heart and vigor in my veins. That shit permanently changed me as a person, dramatically reoriented me towards focusing on making music with my life, on top of the usual chemistry and skateboarding.

I'm not getting anything near that with ~30mg, sounds amazing, would love too but the nerve effect is pretty intense so concerned about handling if it I push it harder

 

[Didgital]

Hey so... I posted a bit back about microdosing mescaline before work.. I didn't really measure the dose. What do yall think is a good functional mini dose if I wanted to do it before sayyyyy going to work? If I had to guess I'd say I took 30-50mg but not sure. It was great! I do not want to overdo it tho..

I might start doing it more often and wanted to get some advice from people who have more experience doing it than myself.

In mexico when I was in the Wirikuta desert on a peyote pilgrimage, on the way back someone had cut a rather large button and no one wanted it. I didn't want it to go to waste so I ate it before the trek back to civilization. It was better than coffee and gave me good clean energy. I'd also met an 80 year old mexican lady who told me her husband would eat a single button every day, no alcohol, no tobacco, nothing else and he lived to 100. I'd asked her what she thought about gringos coming to the desert and if it was ok for me to eat them. She was told me it is medicine for anyone who it calls to.

 

[iom]

Shulgin lists a mescaline dose range of 200-400mg for the "sulfate salt". Going by my 1/6th rule to get to a "one beer" level of intoxication, we arrive at 33 mg. Hence 30-50 mg sounds entirely reasonable to me. Of course all I've had were cacti, so I don't really have a personal basis for recommending doses.

As for doing it at work, I think that would depend a lot on the type of work. I think it would be better with work that is mostly physical and/or in a natural outdoor environment such as gardening or landscaping. If I were a farmer then I think that "one peyote button a day" prescription could be quite nice. Otherwise though, I usually prefer sobriety at work. I don't even use caffeine because my body is hypersensitive to it.

 

[xdrc]

I have no advice to give but am eager to hear about which dose you will settle on and what you think about it. Personally I would not go to work on anything beyond caffeine, but you know yourself and your circumstances better than I. Are you trying to go for the stimulant effect or a little beyond that?

Also thanks for that anecdote!

 

[doubledog]

I am also interested in microdosing mescaline (or minidosing as I expect to feel some effects).
Would start with 30mg.

 

[realgar]

Hey so... I posted a bit back about microdosing mescaline before work.. I didn't really measure the dose. What do yall think is a good functional mini dose if I wanted to do it before sayyyyy going to work? If I had to guess I'd say I took 30-50mg but not sure. It was great! I do not want to overdo it tho..

If you are sensitive to mescaline (like me decades ago), I'd suggest 15-30 mg. A higher dose, like 50-60 mg, would interfere with daily activities (again, for a sensitive person).

 

[red22]

They are also not entirely reliable in inducing the entactogenic state

I've never gotten even a slight mood boost from a phenethylamine psychedelic. But I know other people do—it's cuz I'm severely depressed, but my experience still shows just how weak their mood elevation is.

 

[Allylbenzene]

If you are sensitive to mescaline (like me decades ago), I'd suggest 15-30 mg.

I think most people in this thread overlook the influence of enzymes in dictating sensitivity to mescaline. Putting aside MAO, the more relevant enzyme appears to be ALDH (aldehyde dehydrogenase). We frequently ingest things which induce & inhibit ALDH, but inducers are far more common (eg sulforaphane: cruciferous vegetables). Inducers provoke greater tolerance, meaning larger doses are necessary.

In contrast, ALDH inhibitors appear to reduce subjective tolerance implying mescaline dose ranges are lowered significantly. This implies 80-100 mg can plausibly produce a strong experience (under ideal conditions). A microdose range would match what you wrote 15-30 mg.

ALDH is automatically regulated, but if someone unknowingly ingests ALDH inhibitors they would be lucky to discover that 80-100 mg mescaline is equivalent to a strong dose.