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Opioids Loperamide (Imodium) Megathread v. 2

Trans, it is fantastic to hear you found Lope effective as a WD aid.
You mention that by day 3 you considered a redose unnecessary - this may be due to Lope's in-vivo duration: 30 hours until peak plasma concentration, approx. 72 hours until excretion if I remember correctly.
Thus, daily re dosing should not be necessary, and could be rather dangerous due to build up of metabolites.
 
Smack, seems to work well. Very happy with the relief of symptoms. Definitely a good thing to have around. Yes, I noticeby day three I didnt need another. Had some insomnia and boredom mostly. Felt I needed something to take every few hours so I used sweet tarts as a replacement for the felt of taking another pill.
 
SproutOnSmack said:
Trans, it is fantastic to hear you found Lope effective as a WD aid.
You mention that by day 3 you considered a redose unnecessary - this may be due to Lope's in-vivo duration: 30 hours until peak plasma concentration, approx. 72 hours until excretion if I remember correctly.
Thus, daily re dosing should not be necessary, and could be rather dangerous due to build up of metabolites.
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ya, it has a really long half-life. in the past, i didnt notice itching until day two..
 
Hi everyone, new member here. I normally take between 80-100mg of hydrocodone per day but I ran out yesterday and don't go back to the doctor for my new script for 3 more days. I'm in a lot of pain and the WD's are really starting to kick in. Unfortunately all I have access to right now is the multi-symptom loperamide with the simethicone. There is 125mg of simethicone per pill. If I were to take 10 pills for 20mg of loperamide would that be too much simethicone or could it pose a problem? Any feedback would be greatly appreciated!
 
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Simethicone is a gas reliever like in Ovol. Benign in small to med doses but unsure of larger doses.
I think you're better off running to the store to get a regular bottle of lope.
 
Bob,I would say grab just the loperamide. It worked well for me. Held me over till i found something. Took about two hours to kick in but i was a few days in WD. The gel caps seemed to work the fastest. The last day i took them i went almost 12 hour with little than some chills as symptoms. Good luck.
 
Bliss26 said:
Simethicone is a gas reliever like in Ovol. Benign in small to med doses but unsure of larger doses.
I think you're better off running to the store to get a regular bottle of lope.
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It's a non-absorbed anti-surficant which turns small bubbles into large by effecting surface tension of liquids. Though it's not absorbed and from what I remember excreted changed it's probably not a great idea to take a whole bunch of it, but neither is most stuff.
 
TransWs684 said:
Hey all, new memeber but trolled threads for years. Just wanted say I had my first experience with Lope and was surprised. Quick background on me, 120mg oxy a day for severe back pain. Motorcycle accident 8 years ago destroyed my body. Anyways, changing my current pain management and have no been able to find another. After exhausting my last supplies and unable to find anything elsewhere, I remember reading a few things about other people's good results with lope. I just would like to add to it for controlling W/D symptoms. I took 12mg gel caps and about two hours later, ( 2 days in WD) I noticed everything started to subside. Almost got a strange sedation feeling from it. It relieved eenough for me to sleep a few hours and even enough to eat. Very impressed. I no longer fear being out of my supply. Used them for a few days. By the 3 day, I no longer felt I needed to take another dose. I think it would be entirely possible to come off most opiates/opioids.. As for pain, nothing. But I can deal with that compared to WD. My dosage was small,12mg lope morning / afternoon / night. By third day it was 12 mg lope in the Am and by 8 pm I really did feel I needed anything. Good luck to anyone needing something to help them get throw. It works well. I estimate 80-90% symptom free.
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Is very good news. I am on 200 mgs of oxy a day rx'd it for a humerus snap and shoulder shatter. Had 2 days where I went from being on much more oxy than now to nothing then lope and had an experience similar to yours where I felt, dare I say it, happy ? Without oxy ?
 
Loperamide is a wonder drug people for the benefit of opiate withdraw. Besides that there is a noticeable psychoactive effect that was already commented on and is very dirty. You feel sluggish and just bleh. It's nothing to strive for, I'd almost say it's like a low low dose of seroquel. But because taking Loperamide a lot can lead to massive boosts in your tolerance to opiates and a secondary addiction (like for myself). Luckily I just got my hands on a bottle of Gabapentin and that paired with the Loperamide should be all I need. THANK YOU UNIVERSE!!
 
so whats the deal with lope and quinine ,does it allow it to cross the bbb easier or what ,ive used lope in the past but I had to take close to 100 to get relief ,does the quinine work ,if so how much would it take

so inhibiting the p-450 glycoprotein helps as well?

this is kind of all over the place,so many subjective reviews,i know taking a lot works but is there anything u can take with it so you don't HAVE to take so much for relief ?
 
how cool is it to take a drug with 0,3% [h=1]Bioavailability[/h]as i know there isint really a way to get more [h=1]Bioavailability[/h]
 
some say there mix it with some stuff,, i dont remember the name and shoot it up.. thanks for coffee.. is fu**ing crazy
 
yea let me reach over to my collection of fine opiates and just pick something else,theres a reason people choose lope ,....nothing else around,and im not trying to get high
 
not to find out how i get doped from imodium haha.. :)

i see if there no opi's around. there must be other alternativs-. some says kratom works. not for me..

have any of ya got just a little buzz from imodium?.. have read about people there have take 200pills? who says constipated?

codeine extract.. from headace pills... dosent work from my country there also magnesium inn and acetyl acid.. the geeks say is dificult to extract the magsesium out so when u drink the extract u get delly belly. but if you can make a good extract i bed thats the best legal alternativ.
 
My most recent experience with loperamide was ok. I use oxy for pain relief. This month I was out and loperamide help most with WDs. The first day i took it i had an odd feeling from it. Kinda hard to describe, had gel caps. I took 12 mgs and it helped the WD symptoms a lot. About 3 hours later I almost felt like a small buzz, but more like I was drunk. It wore off about 30 minutes later and then just got tired and slept for 2 hrs. Used it for a few days, didn't need much by day 4. Most I took was 40mg in a day. I didn't get any " high", but I did get some sedation, IMO I feel its a option to get those whom run out of there supply. I felt good enough to eat and little house work, but it did nothing for pain. I also used Laxatives to help with Bowel movements. Just my experience, hope it helps someone get by.
 
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