Ketamine salts solubility

[Rectify]

ELEANOR
1-(3,4-dimethylphenyl)-2-ethylaminopropane

 

[AlsoTapered]

ELEANOR
1-(3,4-dimethylphenyl)-2-ethylaminopropane

AKOS010816986

 

[Rectify]

PubChem is not all that relevant to what I'm trying to do here. Most entries don't have good bioassay comments, for example. But if you are looking for a synthesis, look no further, I guess!

 

[AlsoTapered]

Yes, because it won't be the same procedure as fenfluramine synthesis in the slightest manner. One simply adjusts for MW. Even the solubilities of the precursors and intermediates only deviates by a gnats-chuff. Why not go mad and make the chiral compound?

 

[Rectify]

The fenfluramine synthesis is rather odd. I would take a Shulgin-esque approach for ELEANOR.

Why not make the chiral compound? That would give the chiral compound. These next 2 would be the bromopropionate Friedels-Kraft route.

JUNE_BUG
1-(4-methylphenyl)-1-oxo-2-ethylaminopropane

Basically it's just N-ethyl-4-MMC / mephedrone.

XYLODRONE
1-(3,4-dimethylphenyl)-1-oxo-2-methylaminopropane

Looks good a moi.

 

[AlsoTapered]

Friedel–Crafts acylation. Fine if you think working with bromine is a good move. It's cheap crap made my semi-skilled Chinese.

4-methylethcathinone (4-MEC) is already known as NRG-2.

3,4-dimethylethcathinone (3,4-MEC) is already known as NRG-7.

Wow, that took a 30 second search of Wikipedia...

 

[Rectify]

Ok, cool. Add NRG2 & 7 to my 'to do' list, alongside MMDA!

 

[Rectify]

And Visions Of

SUGAR_PLUMES
1-(2-(methylthio)-3,4-dimethylphenyl)-2-aminopropane

Danced In Their Heads.

 

[AlsoTapered]

OK - how are you making the above? I mean what's your commercial precursors?

 

[Rectify]

Essential Oil Trifecta:

SAFROLE
3,4-methylenedioxy-1-allylbenzene

NUTMEG
3,4-methylenedioxy-5-methoxy-1-allylbenzene

ELEMI
1-allyl-3,4,5-trimethoxybenzene

 

[Rectify]

I'm not making anything, but the precursor for that one is 3,4-dimethyl-2-methylthiobenzaldehyde, which may require a custom synth.

 

[sekio]

OK - how are you making the above?

He is the kind of chemist I like and respect the least - the infamous paper chemist. A paper chemist can know anything from a little to a lot about chemistry, and might even be a competent researcher or teacher. But when it comes to any actual practical chemistry they usually lack any experience, and left to their own devices in a real lab they are more likely to make a tremendous mess, damage equipment, or even cause injury than achieve even partial results attempting to carry out any sort of synthesis unsupervised.
I met one before, a new hire at my job. He had a Ph.D and all sorts of accolades and awards. We asked him to make a few hundred grams of a known compound that had a simple synthesis from circa 1900 using common and cheap reagents, and a trivial purification method. A few weeks later he had managed to start a fire attempting a synthesis, but eventually produced perhaps 0.5g of compound or so.
The final straw, I gave him a complex terpene mixture to seperate with column chromatography. He dutifully did so, but neglected to actually analyse the fractions collected. When he gave me back a tray of 50 vials or so, I was dismayed to see that the first 30 contained only solvent and the next 20 - the very least polar and first eluting compound. He had simply collected 50 fractions, tested none of them in any way, and based on nothing at all, decided that was good enough.
He did not stay employed for long after that one...

 

[Rectify]

sekio,

You Are Largely Correct. I Have A Degree In Chemistry, But I Am Basically Self Taught. I Had A Job Once In Chemistry. It Ended Badly. But Proposing Lead Structures I Am Good At, Paper Chemist Or Not.

 

[AlsoTapered]

Maybe you ought to invest in some appropriate software? Older versions of ChemOffice turn up on Ebay from time to time for about £100.

Newer versions are all downloads and are designed to send you to Elsevier to BUY the references whereas those who know simply use Sci Hub.

If nothing else, it provides pretty pictures and provides for things like GMEC calculations so you can see what the chemical will look like 'in nature' although to be fair, I know a lot of compounds bind in a near-GMEC conformation.

 

[AlsoTapered]

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	Pharmacology Biochemistry and Behavior vol. 24 iss. 4 pp.963—965 Differential antagonism of diazepam-induced loss of the righting response DOI: 10.1016/0091-3057(86)90443-0 a a	Jeffrey M. Witkin; James E. Barrett; James M. Cook; Paul Larscheid		1986 April		English
	European Journal of Pharmacology vol. 106 iss. 3 pp.585—591 Cerebrovascular and cerebral metabolic effects of clurazepam and a benzodiazepine antagonist, 3-hydroxymethyl-β-carboline DOI: 10.1016/0014-2999(84)90062-1 a a	William E. Hoffman; James M. Feld; Paul Larscheid; James M. Cook; Ronald F. Albrecht; David J. Miletich		1984 November		English
	Neuropharmacology vol. 58 iss. 2 pp.357—364 Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): Role of GABAA receptor subtypes DOI: 10.1016/j.neuropharm.2009.10.004 a a	Stephanie C. Licata; Donna M. Platt; Daniela Rüedi-Bettschen; John R. Atack; Gerard R. Dawson; Michael L. Van Linn;[...]		2010 February		English
	Neuropharmacology vol. 59 iss. 7-8 pp.612—618 Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure DOI: 10.1016/j.neuropharm.2010.08.011 a a	Bradford D. Fischer; Stephanie C. Licata; Rahul V. Edwankar; Zhi-Jian Wang; Shengming Huang; Xiaohui He;[...]		2010 December		English
	Bioorganic & Medicinal Chemistry vol. 16 iss. 19 pp.8853—8862 A study of the structure–activity relationship of GABAA–benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis DOI: 10.1016/j.bmc.2008.08.072 a a	Dongmei Han; F. Holger Försterling; Xiaoyan Li; Jeffrey R. Deschamps; Damon Parrish; Hui Cao; Sundari Rallapalli;[...]		2008 October		English
	Tetrahedron vol. 47 iss. 23 pp.3665—3710 General approach for the synthesis of polyquinenes via the Weiss reaction DOI: 10.1016/s0040-4020(01)80896-6 a a	Ashok K. Gupta; Xiaoyong Fu; James P. Snydert; James M. Cook		1991		French;English;German
	Tetrahedron Letters vol. 17 iss. 50 pp.4549—4552 Reactions of dicarbonyl compounds with dimethyl β-ketoglutarate V. Simple synthesis of tricyclo [6.3.0.01,5] Undecane-3, 7, 9-trione, a novel cyclopentanoid compound DOI: 10.1016/s0040-4039(00)93928-5 a a	James Oehldrich; James M. Cook; Ulrich Weiss		1976		French;German;English
	Psychopharmacology vol. 161 iss. 2 pp.180—188 Role of GABAA/benzodiazepine receptors containing α1and α5subunits in the discriminative stimulus effects of triazolam in squirrel monkeys DOI: 10.1007/s00213-002-1037-y a a	Snjezana Lelas; James K. Rowlett; Roger D. Spealman; James M. Cook; Chunrong Ma; Xiaoyan Li; Wenyuan Yin		2002 May 01		English
	Psychopharmacology vol. 165 iss. 3 pp.209—215 Discriminative stimulus effects of zolpidem in squirrel monkeys: role of GABAA/α1receptors DOI: 10.1007/s00213-002-1275-z a a	James K. Rowlett; Roger D. Spealman; Snjezana Lelas; James M. Cook; Wenyuan Yin		2003 January		English
	Evolution vol. 63 iss. 4 pp.854—869 EXTREME HOST PLANT CONSERVATISM DURING AT LEAST 20 MILLION YEARS OF HOST PLANT PURSUIT BY OAK GALLWASPS DOI: 10.1111/j.1558-5646.2008.00604.x a a	Graham N. Stone; Antonio Hernandez-Lopez; James A. Nicholls; Erica Di Pierro; Juli Pujade-Villar; George Melika;[...]		2009 April		English
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Now of course we went a step further an carried a proper human study. Pyeyzolam (selective a5) and Zolpidem (selective a1) strongly suggest that all of the positive subjective effects of alcohol are mediated by the a5 subunit whereas the negative effects are mediated by the a1 subunit. Anyone familiar with Zoplidem will recognise that it does has so nasty psychological side-effects such as loss of executive control, retrograde amnesia, mood lability and so forth.

The few who have sampled pyeyzolam will recognize that huge difference in subjective effects. One can get roughly 2 bottles of wine drunk inside 30 minutes and yet not fall asleep not think or do anything inappropriate, stupid or harmful AND the euphoria is cleaner. I know memory-loss was not an issue. Of course, it MAY have some re-enforcing effects but it totally stopped cravings in alcohol dependant subjects.

So don't expect to see it as a street drug, expect it as a medicine to treat alcoholism and maybe, in the fullness of time, as an alcohol alternative.

 

[Didgital]

The problem is, ergot doesn't make LSA.

Supposedly, there is at least one highly valued claviceps paspali mutant that produces direct LA. Was also told it yields 3g of LA per liter of culture every 10 days.

I actually have a bioreactor but never tried to culture anything yet.

How are you going to isolate workable amounts of LSA anyway? Attempting to do chemistry on crude mixtures is a recipe for frustration.

It cant be that difficult? Most natural products just require specific extraction and purification protocols. I employ a ghetto version of flash chromatography similar to CRC in cannabis you just gotta find where your target molecule elutes.. but alot of the pigments are relatively polar and so will stick to the media.
Haven't tried it with morning glories, but it does wonders on other natural products

 

[Rectify]

What I Learned From My Chemical Experimentation:

(1l Being High Makes Other People Jealous.
(2) Don't Take 4-oxonium-amphetamine.

 

[AlsoTapered]

If I may say so, being high only makes a minority of people jealous. Nobody I KNOW would be jealous.

Don't know of the second item.

Start with something legal and simple. p-F ethylamphetamine isn't controlled in most places, p-F P2P is commercially available and adapting this patent is quite possibly the single, simplest route. https://patents.google.com/patent/US4536518A/en

 

[AlsoTapered]

ID ↕ Time add. ↕ Title ↕ Series ↕	Author(s) ↕	Publisher ↕	Year ↕	Pages	Language
	Chemischer Informationsdienst vol. 10 iss. 18 ChemInform Abstract: STUDIES ON 1-SUBSTITUTED 4-(1,2-DIPHENYLETHYL)PIPERAZINE DERIVATIVES AND THEIR ANALGESIC ACTIVITIES. 2. STRUCTURE-ACTIVITY RELATIONSHIPS OF 1-CYCLOALKYL-4-(1,2-DIPHENYLETHYL)PIPERAZINES DOI: 10.1002/chin.197918274 a a	NATSUKA, K.; NAKAMURA, H.; NEGORO, T.; UNO, H.; NISHIMURA, H.		1979 May 01
	Journal of Medicinal Chemistry vol. 21 iss. 12 pp.1265—1269 Studies on 1-substituted 4-(1,2-diphenylethyl)piperazine derivatives and their analgesic activities. 2. Structure-activity relationships of 1-cycloalkyl-4-(1,2-diphenylethyl)piperazines DOI: 10.1021/jm00210a017 a a	Natsuka, Kagayaki; Nakamura, Hideo; Negoro, Toshiyuki; Uno, Hitoshi; Nishimura, Haruki		1978 December		English

 

[Rectify]

I would just get caught if I tried to make drugs. The problem isn't that I'm too stupid to learn lab chemistry, it is that I have never really been taught.