Ketamine salts solubility

[Rectify]

Of Course, Neither One Of You Has Done Anything This Innovative, Prolific, Or Creative.

 

[AlsoTapered]

I can't speak for sekio, but a few people here have developed multiple novel compounds for the RC market but development is a long, slow and boring process. You don't draw something an proclaim it will produce a given action. So the more novel, the higher the number of unknowns and nobody wants to accidentally discover the next thalidomide.

 

[Rectify]

These Are Just Lead Idea Compounds. There Is No Guarantee Of Activity Or Safety In Many Cases. I Just Initiate The Process. And The Names I Give Them Are Obviously Only Colloquial, As A Rule. In Some Cases, The Synthesis May Be Prohibitively Difficult Or Even Impossible. YMMV. Your Mileage May Vary.

GNARLS_BARKLEY
1-(3,4-dibromo-2,5-benzoquinone-1-yl)-2-aminopropane

DIXON
1-(3,4-dimethyl-2,5-benzoquinone-1-yl)-2-aminopropane

EL_VIRA
1-(3,4-methylenedioxy-2,5-benzoquinone-1-yl)-2-aminopropane

But, Like I Said Earlier, I Am Not Allowed To Have MDxx Compounds Anymore.

 

[Rectify]

EROS
1-(4-methyl-2,5-benzoquinone-1-yl)-2-methylaminopropane

ERAS
1-(4-ethyl-2,5-benzoquinone-1-yl)-2-ethylaminopropane

VERY_OXY
1-(3,4-methylenedioxy-6-methoxy-2,5-benzoquinone-1-yl)-1-carbomethoxy-1-(2-piperidinyl)methane

SIMSTIM
1-phenyl-1-(2-piperidinyl)-methanone

SPUNYON
1-(3,5-dimethoxy-4-(propylthio)phenyl)-1-(2-piperidinyl)-methanone

A SPUNYON Is A SPUN YOUNGIN'.

 

[Rectify]

FAST_N_BULBOUS
1-(3,5-dimethoxy-4-iodophenyl)-1-(2-piperidinyl)-methanone

<PYRIDINYL_30>
1-(3-pyridinyl)-1-(1-methyl-2-pyrrolidinyl)-methanone

DMT_MDA_HYBRID_THEORY_AMPLE_EXAMPLE
4-(2-amino-2-methylethyl)-3-(2-dimethylaminoethyl)-6,7-methylenedioxyindole

TESLA
4-(2-amino-2-methylethyl)-3-(2-dimethylaminoethyl)indole

AMP-DMT Hybrid

PFENNIGAN'S_WAKE
N-(2-phenyl-1-methylethyl)-piperidine-4-oxybenzene

ULYSSEYS
N-(2-(3,4-methylenedioxyphenyl)-1-methylethyl)-4-carbomethoxypiperidine-4-oxybenzene

 

[Rectify]

AZAZA
1-diethylamino-2-methyl-3-phenyl-4-oxo-5-azacyclohexane

ZSA_ZSA
1-dimethylamino-2-methyl-3-(3,4-methylenedioxyphenyl)-4-oxo-5-azacyclohexane

COCK_A_MAMIE
N,N-dimethyl-2-phenyl-2-(2-piperidinyl)acetamide

 

[Rectify]

So, you like cocaine?

COCA_LA
3-(phenylcarbonylamino)-2-(N,N-dimethylaminocarbonyl)tropane

The LA stands for "Long Acting."

So, you want a nummy?

NUMMY [the b is silent]
2-carbomethoxy-3-(4-aminophenylcarbonyloxy)-tropane

Inspired by BENZOCAINE:

1-amino-4-carboethoxybenzene

 

[Rectify]

These 2,5-di-oxo-phenyls are as smooth as silk. On Prancer. On Donner. On DIXON.

 

[Rectify]

THE_REAL_MC_COY_DECOY
1-(4-pentyl-2,5-benzoquinone-1-yl)-2-aminopropane

THE_SQUARE_DANCING_HATFIELDS
1-(3,6-dimethoxy-4-pentyl-2,5-benzoquinone-1-yl)-2-aminopropane

 

[AlsoTapered]

�

ID ↕ Time add. ↕ Title ↕ Series ↕	Author(s) ↕	Publisher ↕	Year ↕	Pages	Language
	Drug Development Research vol. 1 iss. 1 pp.83—88 Alfentanil (R 39 209) — a particularly short-acting intravenous narcotic analgesic in rats DOI: 10.1002/ddr.430010111 a a	C. J. E. Niemegeers; P. A. J. Janssen		1981		English
	Drug Development Research vol. 1 iss. 2 pp.167—179 Effects of morphine, fentanyl, sufentanil, and the short-acting morphine-like analgesic alfentanil on the EEG in dogs DOI: 10.1002/ddr.430010210 a a	Dr. A. Wauquier; W. A. E. Van Den Broeck; C. J. E. Niemegees; P. A. J. Janssen		1981		English
	Psychopharmacology vol. 57 iss. 1 pp.21—26 Narcotic cuing and analgesic activity of narcotic analgesics: Associative and dissociative characteristics DOI: 10.1007/bf00426952 a a	Francis C. Colpaert; Carlos J. E. Niemegeers; Paul A. J. Janssen		1978		English
	Journal of Medicinal Chemistry vol. 29 iss. 11 pp.2290—2297 Synthetic 1,4-disubstituted 1,4-dihydro-5H-tetrazol-5-one derivatives of fentanyl: Alfentanil (R 39209), a potent, extremely short-acting narcotic analgesic DOI: 10.1021/jm00161a027 a a	Janssens, Frans; Torremans, Joseph; Janssen, Paul A. J.		1986 November		English
	Clinical Therapeutics vol. 32 iss. 7 pp.1427—1436 Pharmacokinetics, analgesic effect, and tolerability of a single preprocedural dose of intranasal fentanyl in patients undergoing drain removal after breast reduction or augmentation surgery: A prospective, randomized, double-blind, placebo-controlled study DOI: 10.1016/j.clinthera.2010.07.001 a a	Nicole M.L. Veldhorst-Janssen; Audrey A.A. Fiddelers; Paul-Hugo M. van der Kuy; Alfons G.H. Kessels; H. Maurice S. Theunissen;[...]		2010 July		English
	Neuropharmacology vol. 51 iss. 3 pp.447—456 Antinociceptive activity of chemical congeners of improgan: Optimization of side chain length leads to the discovery of a new, potent, non-opioid analgesic DOI: 10.1016/j.neuropharm.2006.04.003 a a	Lindsay B. Hough; Iwan J.P. de Esch; Elwin Janssen; James Phillips; Konstantina Svokos; Brian Kern; Jennifer Trachler;[...]		2006 September		English
	European Journal of Pharmacology vol. 46 iss. 3 pp.199—205 Receptor affinity and pharmacological potency of a series of narcotic analgesic, anti-diarrheal and neuroleptic drugs DOI: 10.1016/0014-2999(77)90334-x a a	Kenneth D. Stahl; Willem Van Bever; Paul Janssen; Eric J. Simon		1977 December		English
	Journal of Pharmacy and Pharmacology vol. 10 iss. 1 pp.14—21 A NEW SERIES OF POTENT ANALGESICS: Dextro 2:2-diphenyl-3-methyl-4-morpholinobutyrylpyrrolidine and related basic amides: Part II :Comparative analgesic activity, acute toxicity and tolerance development in rats for R875, morphine, pethidine and methadone DOI: 10.1111/j.2042-7158.1958.tb10268.x a a	Janssen, Paul A. J.; Jageneau, Anton H.		1958 September		English
	Journal of Medicinal Chemistry vol. 21 iss. 5 pp.474—476 Synthesis and analgesic activity of some long-acting piperidinospiro derivatives of methadone DOI: 10.1021/jm00203a014 a a	Frincke, James M.; Henderson, Gary L.; Janssen, Paul A. J.; Van der Eycken, Cyriel A. M.		1978 May		English
	Journal of Pharmacy and Pharmacology vol. 13 iss. 1 pp.513—530 PIRINITRAMIDE (R 3365), A POTENT ANALGESIC WITH UNUSUAL CHEMICAL STRUCTURE DOI: 10.1111/j.2042-7158.1961.tb11864.x a a	Janssen, Paul A. J.		1961 September		English
	Journal of Pharmacy and Pharmacology vol. 28 iss. 3 pp.183—187 The narcotic discriminative stimulus complex: relation to analgesic activity DOI: 10.1111/j.2042-7158.1976.tb04127.x a a	Colpaert, F. C. ;Niemegeers, C. J. E. ;Janssen, P. A. J.		1976 March		English
	ChemInform vol. 18 iss. 16 ChemInform Abstract: Synthetic 1,4-Disubstituted-1,4-Dihydro-5H-tetrazol-5-one Derivatives of Fentanyl: Alfentanil (R 39209), a Potent, Extremely Short-Acting Narcotic Analgesic. DOI: 10.1002/chin.198716217 a a	JANSSENS, F.; TORREMANS, J.; JANSSEN, P. A. J.		1987 April 21
	Chemischer Informationsdienst vol. 9 iss. 46 ChemInform Abstract: SYNTHESIS AND ANALGESIC ACTIVITY OF SOME LONG-ACTING PIPERIDINOSPIRO DERIVATIVES OF METHADONE DOI: 10.1002/chin.197846256 a a	FRINCKE, J. M. ;HENDERSON, G. L. ;JANSSEN, P. A. J. ;VAN DER EYCKEN, C. A. M.	Wiley	1978 November 14

Useful papers pertaining to Jannsen's development of R4066 derivatives, dextromoramide (Palfium) and alfentanil (Alfenta).

It's worth noting that Jannsen first explored the 3,3-diphenylheptanone class and then moved to the phenylpiperidnylpropanamide class as it's simpler synthesis and higher activity would be cheaper to develop and if successful, cheaper to produce. It's worth noting that it's hard to produce very short-acting 3,3-diphenylheptanone analgesics and indeed with the ORLA derivative of R-4066 IS very potent (x212 M), it's duration of action is about 2 days.

I would certainly be interested to know if the cyclopentylamide moiety of dextromoramide is compatible with the N-substitution of R-4066 because the parent compounds both have a duration of 3 hours and a Palfium-like drug with a potency of over x100 morphine would most certainly be a VERY attractive target. Fake Palfium would sell a LOT although I hate fake pills. People have the right to know how much of what they are taking - without that, informed consent isn't.

 

[Rectify]

KATMANDU
1-(3,4,5-trioxocyclohexyl)-2-methylaminopropane

TIMBUKTU
1-(3,4,5-trioxocyclohexyl)-2-ethylaminopropane

TISKET
1-(4-oxocyclohex-2,5-diene-1-yl)-2-methylaminopropane

CLEVER_AS_EVER
1-(3,4-dioxocyclohex-1,5-diene-1-yl)-2-methylaminopropane

 

[Rectify]

All I Have To Say Is That The McCoys & Hatfields Are Hard Core.

 

[Rectify]

EARLE_T
1-(2,4-dioxo-6,6-dimethylcyclohexyl)-2-methylaminopropane

 

[AlsoTapered]

Library Genesis

libgen.rocks

Analgesics From Chemistry and Pharmacology to Clinical Application

Another must have tome.

 

[Rectify]

MARIE
1-(4,4-dimethyl-2,6-dioxocyclohexyl)-2-ethylaminopropane

 

[Rectify]

THE_WOKE_AGENDA
1-(4-oxo-5-oxaindole-3-yl)-2-dimethylaminoethane

The indololactone precursor

O=C1C=2C=CNC2C=CO1

is commercially available.

SWEET

SWEET_DREAMS
1-(4,5-dioxoindole-3-yl)-2-dimethylaminoethane

Na+[-CO2-CH2CH3CH2-OH]

WET_DREAMS
Sodium gamma-hydroxybutyrate [GHB]

Do *NOT* Mix With Alcohol.

HO-CH2CH2CH2CH2-OH

NOCTURNAL_EMISSIONS
1,4-butanediol; 1,4-BDO

2 Ethyl Alcohol Molecules Attached Together Backwards. In Case Of Overdose, Administer ICE Methamphetamine.

 

[Rectify]

SAINT_PETE
1-(4-oxa-5-oxoindole-3-yl)-2-diethylaminoethane

PENN
1-(4-oxo-3-oxaphenyl)-2-methylaminopropane

TELLER
1-(3-oxo-4-oxaphenyl)-2-ethylaminopropane

 

[Rectify]

If You Are Currently Located In NYC Or DC, Then Today Would Be A Great Day To Evacuate! June 8th, 2023 AD.

 

[Rectify]

PARVATI_FELICIA_NORIEGA_ANN_VASQUEZ
N-allyl-1-(3,4-dimethyl-2,5-benzoquinone-1-yl)-2-amino-1-methoxypropane

The Works.

 

[Rectify]

IF_COMPUTERS_COULD_GET_HIGH
1-(4-trimethylsilylphenyl)-2-aminopropane