Seith. u honestly dose 1.6g of codeine phosphate?
really? & its stronger than 400mg?
I was convinced fom many sources than the max dose the codeine could be converted to morphine is around 450mg.
Ive fairly reguarly takin 400mg codeine phosphate for quite a while & get no nausia, itchiness or anything like that. just a high which i wish was stronger.
this could be a good if I could dose 1.6g of codeine & get 4 times as high. this sounds to good to be true. Some sources say the LD50 for codeine is between 0.8 & 1.3 grams. So im not really game to take any more than 600mg
I do remember doing cwe on a pack of panadeine forte (600mg codeine) & getting a much stronger effect than my usualy 360, or 400mg)
so what now. are ppl saying the 450mg dose is a myth. because according to seith if he's telling the truth than it is a myth & we could all be getting more out of codeine.
If all 1.6g of codeine is metabalizes into morphine, than codeine would actually be pretty good opiate. its only the ceiling effect that that doesnt make it as good as morphine itself.
infact with some of codeine other metabolites. i think hydromorphone & nor codeine comes to mind than it would potentially be better than morphine (if used orrally)
sounds like BS to me. to good to be true.
can someone help me find evednce on the internet (not just a cwe site) where tests have proven the averag dose where supposingly the liver is saturated with codeine & cannon convert more to morphine?
oh & mods this thread should really be in BDD
I read a couple of yrs back, that, initially Codeine at any dose, taken in one day, would be converted to Morphine ( 10 % ).
But it needs our liver enzyme called CYP 450 2D6 to convert it. In this case, the first dose, Codeine acts as a substrate.
If a second dose is taken ( any amount of codeine) within the same day, then, Codeine becomes an Inhibitor of CYP 450 2D6. So, conversion to Morphine is reduced. That's why, when I take a second dose within the same day, I don't feel the same "Kick" as the first dose.
As far as I know, Codeine, unlike Pentazocine and buprenorphine, is a pure Agonist, so as long as our liver could produce the isoenzyme CYP 450 2D6, there is no ceiling effect. ( I read, Glutethimide, a sleeping agent,and Dexamethasone,a corticosteroid, actually the only 2 drugs that boost this CYP 450 2D6, making Codeine being metabolised into Morphine ). So , theoretically, if Codeine at any dose is taken with any of these 2 drugs, it will be all metabolised to Morphine.
I tried Pentazocine, it's a partial Agonist, and its effect is no difference like taking Mersyndol, an OTC analgesic combo. I read before abt Buprenorphine, it has a ceiling effect at 12mg, being antagonist at "mu" receptor ( This is where we get the high and analgesia, but still retains being agonist at "kappa" and "delta" receptor).