But what holds the worse psychological addiction , the booze and benzo's or the opioides beside from severity of withdrawal ?
Is opiod addiction the worst addiction?
- Thread starter Byzek
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Barbiturates are definitely more dangerous than benzos. Barbiturates have the ability to essentially hold the GABA A channel open during times when it would normally be closed. Benzos on the other hand don't increase the open time, they just increase the amount of Chloride ion entering the cell when GABA binds. (Source reddit) so this is why barbs are so dangerous compared to benzo's its there mechanism on the gaba a receptors .
I just thought because something like diazepam and alprazolam do not feel like alcohol at all to me . I honestly don't even like being drunk , and since barbs hit the same gaba a receptors i thought they would be more identical to benzo's then booze . But i have never tried a barb so i would honestly not know .
ConeyIslandBaby
Ex-Bluelighter
The potential for death with withdrawals from Booze and benzos is what makes them so scary. Hands down worst kick ever was taking myself down from a raging benzo (diazempam and temazepam) habit, cold turkey. Damn near killed me. My health was never the same. Same with booze - seizures and DTs can kill someone. Psychologically I really think it depends on the person. I really believe that some people are more attracted to stims and some more to downers. It depends which team you are on. I don't see myself ever living happily forever without opiates, but that is just me. I can take or leave coke and speed, I can do it and keep it occasional. I can't do that with my drug of choice. Benzos and barbs are junk drugs to me, only useful when there is nothing else.
Damn bro i hope you are doing oke ! I definitely agree with the things you say , in the end of the day its just your chemical makeup in what kind of high you like . But no doubts alcohol and benzo's/barbs tops dangerous withdrawals .
Be safe man !
ConeyIslandBaby
Ex-Bluelighter
Im alright - I have a few lingering health issues from those days, and wish I had never done it, but I manage. Nowadays I stay away from benzos and booze which were definitely the most immediately damaging to me. You stay safe too! It is so hard to stay safe nowadays. Im not saying opiates are safe or a walk in the park, esp with fent, and I have overdosed more than a few times, but am more functional on them than benzos and booze. I was an absolute disaster.
Its good to see a different aspect , because i first stated opioides where worse in addiction and i kinda got some negative response . But you saying you are more stable functional on opioides compared to benzo's and booze made me think differently honestly . I no doubt alcohol is worse on your health compared to anything when being a Alcoholic . I have seen severe cases myself including a friend of my mother , her son was a Alcoholic and he was found dead in his home . He didnt want to go to detox and was so severely dependant on alcohol that he probably got grand mall seizure and a brain bleeding or something . His brain was alrdy damaged and was probally kindled as hell . I think the kindling aspect of gaba withdrawals should be more known cause even with professionals they never heard of it and its actually a very important thing in my opinion.
I hope you can stay clean from the booze my friend , can't imagine how difficult alcoholism is since alcohol is pretty much everywhere . I myself have ghb addiction but i still need to get it and pretty much no one uses that shit . With alcohol its just everywhere
ConeyIslandBaby
Ex-Bluelighter
I haven't had a drink for over four years. It doesn't interest me any more. It actually disgusts me. The only reason I was drinking was to stay off the opiates. I knew someone who died from alcoholism, it was brutal. GHB is not something I have ever done. I hope you are staying safe as possible. It really is a very personal thing, and of course opiates get out of control. I can function really well in society as long as I have enough supply. I was clean for a while, but am currently back on them. I know that because of fent, this can't carry on. I can and have had some functional times on opiates...Ive also had some really dark times where I am not functional at all. In general booze and benzos were far worse. I was not functioning at all.Its good to see a different aspect , because i first stated opioides where worse in addiction and i kinda got some negative response . But you saying you are more stable functional on opioides compared to benzo's and booze made me think differently honestly . I no doubt alcohol is worse on your health compared to anything when being a Alcoholic . I have seen severe cases myself including a friend of my mother , her son was a Alcoholic and he was found dead in his home . He didnt want to go to detox and was so severely dependant on alcohol that he probably got grand mall seizure and a brain bleeding or something . His brain was alrdy damaged and was probally kindled as hell . I think the kindling aspect of gaba withdrawals should be more known cause even with professionals they never heard of it and its actually a very important thing in my opinion.
I hope you can stay clean from the booze my friend , can't imagine how difficult alcoholism is since alcohol is pretty much everywhere . I myself have ghb addiction but i still need to get it and pretty much no one uses that shit . With alcohol its just everywhere
Nice i am glad to hear you are clean for so long now
ghb is somewhat like a cleaner version of alcohol , it has its own set of problems . In Italy its actually prescribed in severe cases of alcoholism because it drastically reduce cravings. although its pretty easy to get addicted to ghb, since it doesnt cause any organ damage like alcohol even with alot of use , with that its also very easy to dose around the clock 24/7. Its got a bad reputation like daterape drug because it can induce coma like sleep . Its also fda approved for the treatment of narcolepsy .
ConeyIslandBaby
Ex-Bluelighter
Clean from booze. Not clean from opiates. Currently use opiates and weed.Nice i am glad to hear you are clean for so long now
ConeyIslandBaby
Ex-Bluelighter
I wondered how it could be used recreationally. You get it prescribed or dark web? Do you actually enjoy doing it?
I was going to say alcoholism or heavy benzo addiction. Because quitting is risking your life.
Fertile
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Not with this - it's normethadone that causes long QT and theoretically dinormethadone (except that primary amine reacts with ketone to produce imine) which is why ORLAAM was discontinued. In this case, the amine is always tertiary. Also, it's LogP is so high that it sits in the brain and other fatty tissue... and lastly, the Long QT isn't associated with the compounds MOR affinity.
But I think the MOST telling is that the 3,3-diphenylheptanone class of compounds were all tested for long QT by Janssen, and R-4066 doesn't cause it - or rather, not until the test animals all died due to collapse of respiration.
looked into R-4066 in great detail...
Interesting though, isn't it.
Oh, and do you know the DOA for the thiambutenes? Someof those could end up with nor and dinor compounds. I am very interested to know if the 3,4-dihydro-2H-spiro[naphthalene-1,4'-piperidine] moiety seen in R-4066 can be applied. THAT would be both interesting and useful in a training set. As you know, the ketone of the 3,3-diphenylheptanone class can be substituted for an ethansulfonate as can the ketone of ketobemidone.
brokedownpalace10
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In the post you made previous to this one I am answering, you spoke of how they hit those gaba a receptors differently. Maybe you answered your own question.
Not sure saying a barb is "whisky in a pill" is saying it "feels like alcohol" exactly, but I will admit that it was inaccurate I suppose. By the same token, they feel quite different than benzos.
They used to say that barbs, Doriden, Placidyls, et all were "sedatives" and that benzos were "tranquilizers". Maybe that's a few more words to throw at it to try to describe the subjective differences.
fastandbulbous
Bluelight Crew
I had (poor fucker is dead now), who had out of control alcohol dependence. Even after developing cancer in one of his kidneys (alcohol is a class 1 carcinogen), he couldn't stop. Spread to his bones and that is basically a death sentence. Barbiturates aren't classed as a carcinogen, but abrupt withdrawal is just as dangerous as abrupt withdrawal from alcohol.
Lost any taste for alcohol after seeing alcohol dependant friends die, from various things (all I can say is, "thank fuck"). I am functional, despite a repeat script for opiates, benzos & pregabalin (phantom limb pain is torture). Can't say the same even with low doses of alcohol...
Lost any taste for alcohol after seeing alcohol dependant friends die, from various things (all I can say is, "thank fuck"). I am functional, despite a repeat script for opiates, benzos & pregabalin (phantom limb pain is torture). Can't say the same even with low doses of alcohol...
Delmonte421
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I would take phenobarbtaual, yellow jackets I believe they called them, and honestly I felt nothing. I was so confused on why is was controlled when I would take stupid amounts and it would do nothing to me.
brokedownpalace10
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Yellow Jackets were Nembutal... Pentobarbital. They are short or intermediate acting. Phenobarbital is a long lasting barbituate which people seem to say is harder to get a high from. I've never had phenobarb, but Nembutal I've had prolly more than any other.
Yeah i understand . Thanks for your explenation .
Still tops booze over health anyday . I hope you can beat your demons man , be safe ! My thought is always if you do use do it safely , don't ever go nuts with opioide doses .
Same here , more like tame your demons . They rlly don't ever go away for me either unfortunately.