Yeah, I just recently developed Panic Disorder (it runs in the fam, and ive been having some crazy shit going on lately, plus recovering for a MAJOR oxy addiction), and had to be admitted to the ER thinking I was having a heart attack. Major major panic attack. Called my doc whos prescribing me subs the next day and he called in a scrip of 2mg klonopins twice a day. I asked him if the mix was bad, he said at those doses, no (i take 12mg subs 2x daily). I asked the pharmacist the same question, he said id be fine. Today I took my sub when I woke up, followed by the klon. Felt some chest tightness come on about 20 min after (my first warning sign of a panic attack, probably was scared of the mix despite the assurances i was given). 30 min later and it was getting worse, no relief from the k-pins at all. So I called the pharmacy (doc's office is closed today and he has no answering service), explained the deal and asked them if it would be safe for me to take half of another k-pin. She said "absolutely, you'll be fine." So yeah, I think you hear all those warnings about benzos from the manufacturer of subs and from your doctors because they are legally obligated to tell you about all the possible side effects. Its not conisdered unlikely to cause respiratory depression when mixed, but its not likely either. Its when you get into actual abuse doses that you get into the danger zone. And considering you're taking subs from abusing drugs, they want to make it clear to you. At prescribed, therpeutic doses, its perfectly fine. My question for the group, however is..... how does a small amount of cocaine fit into this mix? (by small i mean 2 or 3 1.5 inch lines, pretty thin ones at that) I feel fine so far, aside from the heightened heartbeat, which occasionally feels a tad weak. Actually, I just timed my BPM, im at 75 BPMs which is in the "normal" range. I know people advise against combining uppers and downers, but again, I think its when you get into the high doses that you get into trouble. Feedback would be appreciated.