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Heroin Is heroin dying out?? Losing popularity?

You would think the Mexican cartels would see a benefit in developing an opioid that was safer than fentanyl, because it's killing off so many of their customers. Make it safer and more euphoric and they could even expand their customer base. The main advantage of fentanyl mostly just seemed to be cheaper to produce, plus no reliance on large farms of opium that could be raided, smaller amounts to smuggle, so easier to do. But fentanyl is more like a liability now.
It doesn't appear to me that they have many intellectual resources for developing new drugs, but I would think they could develop ties with the RC chemists in Europe. I gather that it is a well-established and creative industry for it there. I think I read or heard that the Mexican cartels are maybe already starting to help set up meth labs in Europe (?) Of course the cheap cost of making fentanyl from Chinese chemicals is hard to fight against. Maybe there would be a 2 tiered system of quality and price between fentanyl and some new opioid. Gotta have some product for the poorest of the poor, but meanwhile people with more money could buy better more expensive stuff...at least until their addiction pushes them down into needing the cheaper stuff.
In the meanwhile, as had been said, not many new opioid customers when it's only shitty fentanyl available( or worse, cut with xylazine)
 
Given that cartel leaders don't typically have long lives, I suggest that if it's a case of making money now or making money in the future, they will always choose NOW.
 
Yeah, and their business model does not involve being niche or boutique. More like, extract the most profit ASAP and kill your rivals and customers along the way. I can't imagine that anyone would feel too safe being in business with the cartels. And how many Euro chemists want to go live in the remote Mexican countryside for very long?
 
I was unaware that ANY Europeans had been convinved to visit sunny Mexico. It's just a dangerous place to be & mixing with cartel-types cannot be good for life expectancy.
 
I was unaware that ANY Europeans had been convinved to visit sunny Mexico. It's just a dangerous place to be & mixing with cartel-types cannot be good for life expectancy.
Yeah, I was reading some articles about the mexican chemists that the cartels had been recruiting to try to adjust their fentanyl recipes. Hard to understand what they were doing but it wasn't really inventing new drugs, more like mixing crap in to make it somehow better for business. There have been reports of fentanyl that tastes like nail polish or plastic and doesn't get you very high. There is also all the mixing of xylazine in
Anyhow, the "chemists" recruited were more like first year chemistry students at local small colleges. About all their training consisted of was basic use of a chemical lab. Now they were working in lousy conditions under the eye of the cartel. Making good money by local standards but in danger of getting killed if they failed. Sounded awful.
 
Yeah, I was reading some articles about the mexican chemists that the cartels had been recruiting to try to adjust their fentanyl recipes. Hard to understand what they were doing but it wasn't really inventing new drugs, more like mixing crap in to make it somehow better for business. There have been reports of fentanyl that tastes like nail polish or plastic and doesn't get you very high. There is also all the mixing of xylazine in
Anyhow, the "chemists" recruited were more like first year chemistry students at local small colleges. About all their training consisted of was basic use of a chemical lab. Now they were working in lousy conditions under the eye of the cartel. Making good money by local standards but in danger of getting killed if they failed. Sounded awful.

I think I watched that video - they rere actively recruiting students. If it's the one where the journalist arrives to witness one of them putting out a fire, it IS the one.

I mean, full marks for whoever telescoped the synthesis down to such simple chemistry but it's my belief that there are now layers of chemists. I don't think ANPP is controlled in Mexico but it IS controlled in China so I believe you have more skilled chemists making the precursors (legally) and only the final step that produces an active that the cooks (because they are NOT chemists) perform the final step on.

Propionic anhydride is now closely watched BUT there are legal alternatives that I haven't heard of being used so far. I expect SOMEONE will work it out as it isn't very difficult - more like lateral thinking.
 
@Esperighanto Yes, you are right. Our street speed (amphetamine) is indeed in 999,999/1,000,000 cases bound with "sulfate" salt, but the drug "Elvanse," also called "Vyvanse," actually changed from sulfate to dimesylate. Most of our street amphetamine now uses dimesylate, since 3-4 years ago, meaning the change occurred in late 2020.

Here are some very basic pieces of information:

Sulfate:

  • Chemical Composition: Sulfate is a salt or ester of sulfuric acid containing the anion SO₄²⁻.
  • Usage: Sulfates are commonly used in various industries, including pharmaceuticals, detergents, and fertilizers. For example, dextroamphetamine sulfate is a common form of medication used to treat ADHD.
Dimesylate:

  • Chemical Composition: Dimesylate is a salt formed from the reaction of a compound with two molecules of methanesulfonic acid (mesylate).
  • Usage: Dimesylates are often used in modern pharmaceuticals to improve the solubility and stability of the active ingredient. For example, lisdexamfetamine dimesylate is a prodrug used to treat ADHD and binge eating disorder.
In summary, while both sulfate and dimesylate are used to form salts of active pharmaceutical ingredients, they differ in their chemical structure and specific applications. Sulfates are more commonly found in a variety of products, whereas dimesylates are specifically used to enhance the properties of certain medications. However, as I mentioned above, this fact has changed, and amphetamine with dimesylate salt has been discovered. The only reason I could imagine for this is the stability (especially for transportation), improved solubility (meaning it can be better absorbed than sulfate amphetamine), and the controlled release, meaning the effect would last longer.

I'm not a chemistry professor by any means, but binding dimesylate salt with normal amphetamine would require a lot of work and skill, as well as modern technology. It is way more expensive than the good old "amphetamine sulfate" way. As I said, that was incredibly rare. We only have access to 7 total records of this special amphetamine charge, and I never saw it with my own eyes. But the people who told me about it were actually teaching chemistry at my neighboring university, so I'm very, very sure they told the truth.

Another thing I wanted to tell you is that almost all RC drugs are always in HCL form because it's very cheap and very effective (body absorption). All benzodiazepines are always in HCL form, as well as cathinone analogues, such as 3,4-EtPV (3,4-dimethylene-α-Pyrrolidinovalerophenone), which is an MDPV analogue. Reports also said that it's a very strong stimulant. But again, many powdered substances that you can find will be in HCL form. There are exceptions like Phenibut FAA, which I greatly recommend because it's not as bitter and salty as the HCL form, and it's also healthier because HCL can be very toxic in high doses. Many started to vomit blood, so be careful there.

But back to Tianeptine, it's actually the only medication here in my country that uses sodium salt, which is believed to reduce absorption, making it harder to abuse. It's the same as our Tilidine products. Let me send you a photo.


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Tilidine-kaufen.jpeg
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I don't know if it's the same in the U.S., but you can see how many pharmaceutical brands exist over here, right? That's only a small portion of brands. However, you can see that every dose of tilidine is paired with naloxone, right? That is to ensure that you cannot overdose and abuse it too much. When you reach more than 300mg of tilidine (24mg of naloxone), the naloxone is triggered, and the rush is over.

For everyone who doesn't know: naloxone is a potent opioid receptor antagonist. It's often used to rescue people from opioid overdoses, especially from fentanyl in the U.S. Tilidine is an opioid that's only available here in my country and in 3-4 other smaller countries in Europe. Everywhere else, it's banned because of its massive abuse potential. It acts not only as a µ-opioid receptor agonist (MOR), but it is also a moderately strong dopamine reuptake inhibitor and a mild NMDA antagonist. The potency of tilidine is 1:5 (compared to morphine), meaning 30mg of morphine would be 6mg of tilidine. However, nortilidine, a major active metabolite of tilidine, is actually the drug that causes all those effects, meaning that tilidine itself doesn't have any psychoactive effects. Nortilidine has the same potency as morphine, meaning 1:1.

In my opinion, tilidine is the best opioid because of its heavy euphoria, caused by the major second effect (dopamine reuptake inhibitor), which makes it one of the most euphoric opioids that you can get. There are also forms of tilidine without naloxone, but those only exist in liquid form and can only be prescribed with a special prescription that can be faked.

In my country, there are two major types of prescriptions that you can get. There are also some others that make you pay less for a drug, but those aren't important:

Normal Prescription (colored pink):


  • Drugs you get with it: tramadol (only pellets, not liquid), codeine (only with pamol, as a combination drug), tilidine (with naloxone), ibuprofen 600mg and 800mg, most benzodiazepines (diazepam, clonazepam, bromazepam, alprazolam, etc.), and basically every medication that isn't psychoactive.
These normal prescriptions can be faked and can be prescribed by any doctor who studied medicine. These are probably comparable with prescriptions in your country, but we also have a second form.

BTM (Betäubungsmittel) Prescription (colored yellow):


  • There isn't a direct translation for BTM. When you ask Google, it says simply "drug." When translated 1:1, it would mean "numbing medium/means."
  • Drugs you get with it: tramadol (all doses and sizes), morphine, tilidine (all doses and sizes), oxycodone, methylphenidate (Ritalin), dexamphetamine (Strattera), lisdexamfetamine (Elvanse/Vyvanse), special benzodiazepines (flunitrazepam and temazepam), etc. Basically everything.
The BTM Prescription is a special form of a prescription that can only be obtained by special doctors, such as psychologists. This means normal doctors (family doctors), where you would go when you are sick, don't have the right and allowance to hand out a BTM Prescription. They are also almost impossible to fake because when you want to "cash in" your BTM Prescription, they fully check every single detail on this prescription and check on their computer if this doctor exists, if they have the allowance, and also compare it with past signatures of the specialized doctors where they signed other BTM Prescriptions. Also, all of the BTM-required meds are stored in a big vault that always has the same quality and security as a bank vault (every drug store in Germany has these measures).
Family drs CAN prescribe BTMs. But for sure, not easy or common to get, even from specialised drs.
 
The doses used medically are generally much lower than the doses typically taken for recreational purposes. The dimesylate is actually a prodrug designed to prevent misuse. No 'rush', you see.
 
IF I was asked to make a guess on the next opioid to hit the market, it would be something much more akin to H but with the added benefit of being around the same potency as fentanyl - but at a higher price.

Such compounds are known to science and AFAIK the key precursors aren't controlled. Of course it would require someone to see a clear market for such a product. They aren't synthetically complex but someone would need to invest in optimizing the process.
They already have hit - nitazenes. I can tell the difference but most people can’t seem to.
 
They already have hit - nitazenes. I can tell the difference but most people can’t seem to.

I have mentioned nitazenes in an earlier post. It seems like fentanyl is still king in North America while the nitazenes are gaining ground in Europe and likely other places.

I'm not sure if the nitazenes are pleasent. Reports seem to vary from 'awful' to 'still buzzing after 12 hours' but that's what you get if you don't get told WHICH nitazene you are taking.
 
Yeah, I took a Vyvanse recently for the first time, a 10 mg one. I think I read that that much lisdexamfetamine will convert to about 4 mg of dexedrine? Not much but I had no tolerance so 4 mg of IR dex would definitely make me pretty high. However this was an unbelievably slow-motion come on. Still felt like a mood booster and I liked it ok, but certainly no rush. Much less recreational potential
 
I just looked at a few conversion tables and lisdexamphetamine is only 25% the potency of dexamphetamine BUT lasts over twice as long so allowing for the higher MW of lizdex, you are just about spot on.
 
I have mentioned nitazenes in an earlier post. It seems like fentanyl is still king in North America while the nitazenes are gaining ground in Europe and likely other places.

I'm not sure if the nitazenes are pleasent. Reports seem to vary from 'awful' to 'still buzzing after 12 hours' but that's what you get if you don't get told WHICH nitazene you are taking.
I don’t like any opioids, I find them all dysphoric just to varying degrees, with h being the least bad and the synthetics usually being the worst (except for methadone). But, there’s a lot of nitazenes in European h (in basically everything both on the street and on DNM for a few years now) and most people seem fine with it, or even prefer it because it’s stronger. Maybe some people don’t know any better, but I truly think a large percentage find it good enough. It seems to have taken over a lot more gradually than fentanyl did in the US, though I haven’t been familiar with the US scene since 2012. I find the side effects distinctive, but maybe that’s because I’m not getting any type of pleasant effect, other than pain relief. And notably, they do little for my pain, don’t last as long, and withdrawal is more intense, especially the sweats.
 
I know that feeling. I'm basically stuck with oxycodone - I can't walk without it and even with, only using crutches and short distances.

When you take them every day, they just cause depression. Also I HATE having to take a medicine just to walk and the dependence scares me.
 
I know that feeling. I'm basically stuck with oxycodone - I can't walk without it and even with, only using crutches and short distances.

When you take them every day, they just cause depression. Also I HATE having to take a medicine just to walk and the dependence scares me.
That sucks so much. I am so glad that I still have my mobility. Of course every single ortho I ever saw in the US wanted to perform very expensive, risky, invasive spinalsurgery that would have permanently reduced my mobility, with no guarantee of pain relief and a high chance of pain increase, and further mutilation of my body. And not a single one of those hundreds of orthos was willing to prescribe me effective painkillers, despite my case being the most extreme they had all ever seen. I found a great ortho right after I moved here, who got me braced & prescribed me exactly what I asked for, but then a year later he killed himself. 😭

I also find them very depressing, and worse, highly demotivating, numbing, spiritually sedating etc.

I am most comfortable when I’m either lying flat or moving quickly & dynamically. But sitting or standing still get very painful for me very quickly, and unfortunately, car, train and plane seats are uncomfortable. I can’t wait for full self driving because I know once it is fully developed there will be proper flat lie down surfaces in cars.

The dependence sucks, for sure, but at least I won’t die if I stop taking it. And I enjoy some aspects of withdrawal. But I am scared of being permanently cut off and becoming essentially bedridden again like I was initially. The idea of never being able to treat my pain is terrifying.
 
Which ones?
I’m going to answer this as well

I love the way withdrawal distills your greater purpose in life. Practically bottles it for you and displays it right there next to a bag of heroin you haven’t quite yet mustered into your own possession yet. And the bottle and the bag are mutually exclusive. You reach for one and you lose the other.
 
I love the way withdrawal distills your greater purpose in life. Practically bottles it for you and displays it right there next to a bag of heroin you haven’t quite yet mustered into your own possession yet. And the bottle and the bag are mutually exclusive. You reach for one and you lose the other.

This is beautifully expressed and while I understand your meaning, the issue that I've had is that I don't see anything in the bottle or any bottle at all.

I got onto opiates because I couldn't face basic life as it was (in my head), and now when I fight to get through withdrawal and actually make it to dependency-free, I have to face what I couldn't handle in the first place. Fifteen years and I haven't figured out how to do this. I wouldn't be able to argue - or necessarily want to argue - if someone said I was a weak-minded individual for this issue I've got myself into.

Sorry. Don't want to derail thread. More on-topic: high purity heroin is, and I believe, always will be desirable. Fent doesn't do much for me, personally. I mean, it's certainly strong but I don't think it's particular enjoyable like H is. If some chemist could make something that was subjectively superior to H, that'd be great (and awful). Gimme some LOL
 
When it comes to Heroin, we are damn lucky here in Australia. Especially with the price halving over the past 2 years without any drop in quality has been a godsend.

Man, i have not seen any indications of fentanyl hitting australia yet... It is still the same china white untouched for me as it always has been..
Damn i would def like to try fentanyl though.... why don't they just cut heroin with a little bit of fentanyl to increase its strength!?
No! That is the LAST thing anyone wants.

If you want to try Fent so badly source it yourself as Fent, dude.

"Why don't they just cut heroin with a little bit of fentanyl to increase its strength!?" - Because that would be damaging the already high-quality product with something far inferior? That's not what customers want!

I have the feeling from reading your post that you may be assuming 'stronger' means better or more enjoyable. That is not the case in the slightest. Anyone who has experienced high purity fully refined #4 Heroin will never get anywhere near that level of euphoria from Fentanyl (if any, some claim Fent has a small amount others say hardly any)

Thankfully there is such huge competition between Asian crime syndicates at the distribution level of bulk quantities if any one of them started cutting their product with fent or anything else (which is not needed, as they get the best of the best cheap already) they would lose their regular buyers and soon the ability to distribute the product at all, due to their former clients quickly moving to another supplier. If you are paying $200,000 for keys of 89%+ purity DOUBLEUGLOBE or Mah Jong bricks and all of a sudden people started complaining that your product tested positive for fent etc you are going to source your keys from another bulk syndicate distributing the same product asap.

We are so lucky to get some of the purest heroin in the world consistently year after year after year.. <3Golden Triangle<3
 
high purity heroin is, and I believe, always will be desirable. Fent doesn't do much for me, personally. I mean, it's certainly strong but I don't think it's particular enjoyable like H is. If some chemist could make something that was subjectively superior to H, that'd be great (and awful). Gimme some LOL
Absolutely. 💯
 
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