There's many many reports of people claiming 25c-nbome feels "safer"/"healthier"/"cleaner" than 25i-nbome
Whether or not this means it's actually safer isn't for sure because there's also plenty of people who find boh substances equally clean or dirty, but I've NEVER heard someone say 25i is cleaner than 25c - always the opposite
It's worth remembering that how a drug feels bears little resemblance to the damage it's doing/the dangers. Take MDMA for example - one of the best, if not the best drug drug for euphoria and feeling great appears to be neurotoxic and significantly damaging in the long run if taken more than infrequently. You could argue that people get bad comedowns so they are feeling it - but not everyone does, I don't get comedowns/hangovers at all from MDMA really but that doesn't mean it's not doing damage.
I'd say 25C is probably less safe than 25I based on my own limited experience with both substances.
1.2mg of 25C-NBOMe taken buccally had my blood pressure sky-rocketing due to vasoconstriction within 25 minutes of putting the substance on my gum. It wasn't quite at "Shit check yourself into hospital" levels but it was very high, higher than I've ever seen it before on any drug or combination of drugs including several day multiple-drug stimulant binges. For reference I measure my blood pressure very frequently when I'm on drugs just to keep track of how different drugs are altering it.
With 25I-NBOMe at 1mg my blood pressure was FAR less elevated and I actually didn't notice much more vasoconstriction at that level than with say for example the 2C-X series. I even managed to add some amphetamine and although I then noticed some notable vasoconstriction it was still less than that of 1.2mg of 25C.
(Note: I would not take that combination again though as I think it's dangerous.)
It's also evident from the dosages people have been taking. The 25I-NBOMe deaths seem to be largely by people doubling their doses and such, while with 25C-NBOMe people have had nasty side effects and ended up in hospital with much smaller dose increases.
None of these NBOMe compounds are really safe at all compared to other psychedelics.
The real key if you want to remain alive and safe with these is to start low (500ug or less with each substance) and then work your way up in increments of 100-200ug, no more.
Why? Well look at the 2C-X series for example. Do you take 20mg of a 2C-X, decide that feels "not quite there" and double your dose to 40mg? Of course not, but people seem to be doing this with the NBOMes for whatever stupid reason - deciding 1mg isn't quite enough, and so they need 2mg.
I think it's due to the small dosages, people think "Well I'm only increasing the dose by 1mg", without realising that hey they're actually DOUBLING the dose.
So if you take 1mg and it's not quite enough for you, jump up to 1.1mg or 1.2mg - NOT 1.5mg or 2mg. That 100-200ug might not seem like a lot but it can make quite the difference.
That's also only if the drug isn't already producing significant vasoconstriction and other side effects. For example I feel like 1.2mg of 25C-NBOMe wasn't quite as strong as I wanted the experience to be, but would I up the dose at all? No way! My blood pressure was already too high from 1.2mg, I don't need to put myself in danger by increasing that further.