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Is 25C-NBOMe safer than 25i?

D

dnc

Greenlighter
Joined
Jan 28, 2013
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4
I`ve seen a lot of reports and articles about 25I-NBOMe related deaths and health risks, but not about 25C-NBOMe. Is the 25C much safer than 25I?
 
I have very little scientific knowledge about these, but have tried both a couple times. I would say no. They both seem to be capable of producing ODs within a few doses.
 
No, we don't know because other factors like prevalence have not been accounted for.

If one of the NBOMe compounds is getting much more exposure and attention it is bound to cause more incidents. I do not know of any study that shows that one NBOMe compound is proportionately safer than others although there is some anecdotal evidence to parse.
 
yes and one fatal report I read made 0 sense. 25i which they also refered to as smiles was taken orally in the form of a gelcap.

that aint an NBOMe.... that is simply a 2ci incident I think that got lumped in.


basic rules are pretty simple for all NBOMe's keep your dosages very low, never try to eyeball anything as it is nearly impossible to see the difference between 1mg and 2mg let alone larger numbers.


anyone jumping in for the first time should know the product intimately at .500 micrograms before moving up in dosages
 
I was thinking of cutting one 600 mcg blotter in half, I think it is fairly safe. All that fatality reports made me paranoid...don`t know if it`s just hyscteric media exagerating, or if the substance is really THAT dangerous in mcg level dosages.
 
Here's the thing man; all of the incidents where people have been having trouble with the 25x compounds have been where the ROA had been insufflation. The thing is pure NBOMe powder is potent as fuuck, you don't really need very much of it for it to work, and people have easily over done it a few times allegedly. If you have blotters however, there really is only so much that can even fit in the paper, and you know (at least approximately) what dose you're taking. I'm not saying you shouldn't proceed with caution, but in my experience 3 of these 1000 mg potent 25i blotters with no tolerance has rendered a fairly intense trip, but nothing earth shattering. I think it would be a waste to cut that blotter in half.
 
Thanks, that was my main issue on that subject - in all those reports, they never say what was the dosage that triggered the incident. I didn't know if it was an overdose from too much substance taken, or some kind of allergic reaction or something like that, which can fuck you up even in the smallest doses.
 
Not giving advice in any way, but theoretically isn't it going to be safer from a pharmacological perspective? 25C is a weaker agonist at 2A than 25I but still elicits a stronger psychedelic response per dose so will cause less peripheral side effects (namely vasoconstriction). Any thoughts on this?
 
I believe that many of the safety issues from NBOMes are a result of the challenges handling and dosing such a potent substance. As cannibalsnail said, it appears likely that it is pharmacologically safer, but used with total responsibility there is no need for either to be particularly dangerous. The dangers come when pushing doses high and when making mistakes which means any difference in safety between NBOMes will be negligible when compared to the difference between NBOMes and 2Cs.
 
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Transform said:
The dangers come when pushing doses high and when making mistakes which means any difference in safety is likely to be negligible when comparing say, 2-CB and 25C-NBOMe.
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I don't think that's particularly good harm reduction - on what basis can we say that?

2C-B is a partial agonist that has been widely used as a recreational drug for many years without a single fatality, and multiple anecdotal reports of huge doses being perfectly fine, if intense (the famous PIHKAL 100mg for instance). 25C is a full agonist, and highly likely to induce the same vasoconstriction seen with 25I at higher doses.
 
specialspack said:
I don't think that's particularly good harm reduction - on what basis can we say that?

2C-B is a partial agonist that has been widely used as a recreational drug for many years without a single fatality, and multiple anecdotal reports of huge doses being perfectly fine, if intense (the famous PIHKAL 100mg for instance). 25C is a full agonist, and highly likely to induce the same vasoconstriction seen with 25I at higher doses.
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that's actually exactly what Transform is saying: the 2C-x series is much safer than the NBOMe series.
 
specialspack said:
I don't think that's particularly good harm reduction - on what basis can we say that?

2C-B is a partial agonist that has been widely used as a recreational drug for many years without a single fatality, and multiple anecdotal reports of huge doses being perfectly fine, if intense (the famous PIHKAL 100mg for instance). 25C is a full agonist, and highly likely to induce the same vasoconstriction seen with 25I at higher doses.
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Specialspack, please don't mind the correction, 25C is a potent partial agonist.

25C-NBOMe (2C-C-NBOMe, NBOMe-2C-C, Cimbi-82, Pandora, Dime) is a derivative of the phenethylamine hallucinogen 2C-C, which acts as a potent partial agonist for the 5HT2A receptor,

The concerns of the NBOME's HR has to enter the picture, benzos, antidotes and propers scales and accurate dosing methods. Lets not forget tolerance and combo's that can alter the effects. I have yet to have a bad experience with 25C, but never took a high dose at once nasal ROA either and doubt I will . I do really look forward to my next 25C trip %)
 
JarBag said:
I'd imagine low doses, yeah. I don't think the NBOMEs are CNS depressants in any way? Correct me if I'm wrong.
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Maybe Mods could help with this, I don't want to be wrong here (or in real life with this one:X.) Common for people to tame 5HT2 agonist trips with benzo's . Could also end the trip with SSRI or even atypicals .

While these meds might help, I would hope the users have an appropriate scale and dosing method and info on dose amounts as well as ROA's. These are very potent compounds, have a steep dose response curve and are not to be handled carelessly. No eyeballing doses please 8)
 
JarBag said:
I'd imagine low doses, yeah. I don't think the NBOMEs are CNS depressants in any way? Correct me if I'm wrong.
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On the contrary, I find them very stimulating. Struggle to sleep for hours afterwards and just chat, dance and laugh all night
 
Benzos are safe in combination with 25x compounds and will diminish the intensity of a trip. SSRIs will NOT abort a trip, although prescription use will render them mostly inactive. Antipsychotics will not abort a trip properly either and have terrible side effects. Stick to benzos in the case of bad trips.
 
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cannibalsnail said:
Benzos are safe in combination with 25x compounds and will diminish the intensity of a trip. SSRIs will NOT abort a trip, although prescription use will render them mostly inactive. Antipsychotics will not abort a trip properly either and have terrible side effects. Stick to benzos in the case of bad trips.
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I have read that risperdal has ended trips. Maybe not true baseline (can't recall the details of various posts) , but was said to be very effective. If you have experimented with all these (ssri, atypical and various benzos) , I am really interested in your findings, doses and which meds. Btw, which benzo's do you like and how much of a dose?
 
Apparently mirtazapine is the drug of choice for aborting trips. Has anyone tried it?

I'm not sure that I agree with daily SSRI use rendering NBOMe's mostly inactive. I have been on 20mg Citalopram daily for 6 months and in that time I can't say I have noticed a difference. It could be that it takes a slightly higher dose to reach the same level but I have been ramping up the dosage/intensity of my trips since then anyway so it's hard to tell. Funnily enough 2c-b on SSRI's seems to be blunted while 2c-c doesn't at all (40mg orally gave me a very intense trip). Everybody's neurological set-up is different I guess.

Anyway - back on topic, I recommend Xanax when the trip becomes too intense, long or or otherwise unwanted. It won't exactly end the trip but it will kill any anxiety (unfortunately along with the magic) and get you to sleep sooner.
 
The side effect profile seems much safer in nearly all of the Chlorinated phenethylamines that are used recreationally but no one can really say that it is safer.
 
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