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Is 25C-NBOMe safer than 25i?

Specialspack, please don't mind the correction, 25C is a potent partial agonist.

25C-NBOMe (2C-C-NBOMe, NBOMe-2C-C, Cimbi-82, Pandora, Dime) is a derivative of the phenethylamine hallucinogen 2C-C, which acts as a potent partial agonist for the 5HT2A receptor,


Sorry, allow me to clarify - both 25I and 25C are almost full agonists as measured via PI hydrolysis, with intrinsic activities of 91% and 88% respectively. Calling 25I a full agonist and 25C a partial agonist is pretty arbitrary, they're equally potent - that's wikipedia for you... ;)

Ref - Ettrup, A. et al. (2010). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging 38 (4): 681–693 http://www.ncbi.nlm.nih.gov/pubmed/21088982
 
Sorry, allow me to clarify - both 25I and 25C are almost full agonists as measured via PI hydrolysis, with intrinsic activities of 91% and 88% respectively. Calling 25I a full agonist and 25C a partial agonist is pretty arbitrary, they're equally potent - that's wikipedia for you... ;)

Ref - Ettrup, A. et al. (2010). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging 38 (4): 681–693 http://www.ncbi.nlm.nih.gov/pubmed/21088982

I suppose words don't represent these compounds well :) I should have known better;) I have had a few high doses of 25I, but only moderate doses of 25C.
 
25i seems to be doing the rounds as the most popular fake acid. This is extremely dangerous and people think they can take more and end up hospitalised. That is probably why there have been more related deaths.
 
Sorry, allow me to clarify - both 25I and 25C are almost full agonists as measured via PI hydrolysis, with intrinsic activities of 91% and 88% respectively. Calling 25I a full agonist and 25C a partial agonist is pretty arbitrary, they're equally potent - that's wikipedia for you... ;)

Ref - Ettrup, A. et al. (2010). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging 38 (4): 681–693 http://www.ncbi.nlm.nih.gov/pubmed/21088982

Now where does that leave 25B? DUN DUN DUNNNNNNNN


And I will be consuming all three within the following six weeks, tomorrow night being the first night, 525ug 25C-NBOMe and 100mg MDMA at T+1:00. I will report, and also contrast differences within my report on 25I when the time comes (:

Then that leaves B again mwahahahahaha they're all so mysterious(ly awesome).
 
There's many many reports of people claiming 25c-nbome feels "safer"/"healthier"/"cleaner" than 25i-nbome

Whether or not this means it's actually safer isn't for sure because there's also plenty of people who find boh substances equally clean or dirty, but I've NEVER heard someone say 25i is cleaner than 25c - always the opposite
 
Now where does that leave 25B? DUN DUN DUNNNNNNNN


And I will be consuming all three within the following six weeks, tomorrow night being the first night, 525ug 25C-NBOMe and 100mg MDMA at T+1:00. I will report, and also contrast differences within my report on 25I when the time comes (:

Then that leaves B again mwahahahahaha they're all so mysterious(ly awesome).

B is more potent IMO but I could be wrong . I only have a mg scale, and it wouldn't compare to a .1mg scale for accuracy:( I use liquid suspension, and try to be as accurate as I can and I would advise treating B as though it is every bit as potent as I or C is to you. Keep us posted%)
 
There's many many reports of people claiming 25c-nbome feels "safer"/"healthier"/"cleaner" than 25i-nbome

Whether or not this means it's actually safer isn't for sure because there's also plenty of people who find boh substances equally clean or dirty, but I've NEVER heard someone say 25i is cleaner than 25c - always the opposite

It's worth remembering that how a drug feels bears little resemblance to the damage it's doing/the dangers. Take MDMA for example - one of the best, if not the best drug drug for euphoria and feeling great appears to be neurotoxic and significantly damaging in the long run if taken more than infrequently. You could argue that people get bad comedowns so they are feeling it - but not everyone does, I don't get comedowns/hangovers at all from MDMA really but that doesn't mean it's not doing damage.

I'd say 25C is probably less safe than 25I based on my own limited experience with both substances.

1.2mg of 25C-NBOMe taken buccally had my blood pressure sky-rocketing due to vasoconstriction within 25 minutes of putting the substance on my gum. It wasn't quite at "Shit check yourself into hospital" levels but it was very high, higher than I've ever seen it before on any drug or combination of drugs including several day multiple-drug stimulant binges. For reference I measure my blood pressure very frequently when I'm on drugs just to keep track of how different drugs are altering it.

With 25I-NBOMe at 1mg my blood pressure was FAR less elevated and I actually didn't notice much more vasoconstriction at that level than with say for example the 2C-X series. I even managed to add some amphetamine and although I then noticed some notable vasoconstriction it was still less than that of 1.2mg of 25C. (Note: I would not take that combination again though as I think it's dangerous.)

It's also evident from the dosages people have been taking. The 25I-NBOMe deaths seem to be largely by people doubling their doses and such, while with 25C-NBOMe people have had nasty side effects and ended up in hospital with much smaller dose increases.

None of these NBOMe compounds are really safe at all compared to other psychedelics.

The real key if you want to remain alive and safe with these is to start low (500ug or less with each substance) and then work your way up in increments of 100-200ug, no more.

Why? Well look at the 2C-X series for example. Do you take 20mg of a 2C-X, decide that feels "not quite there" and double your dose to 40mg? Of course not, but people seem to be doing this with the NBOMes for whatever stupid reason - deciding 1mg isn't quite enough, and so they need 2mg.

I think it's due to the small dosages, people think "Well I'm only increasing the dose by 1mg", without realising that hey they're actually DOUBLING the dose.

So if you take 1mg and it's not quite enough for you, jump up to 1.1mg or 1.2mg - NOT 1.5mg or 2mg. That 100-200ug might not seem like a lot but it can make quite the difference.

That's also only if the drug isn't already producing significant vasoconstriction and other side effects. For example I feel like 1.2mg of 25C-NBOMe wasn't quite as strong as I wanted the experience to be, but would I up the dose at all? No way! My blood pressure was already too high from 1.2mg, I don't need to put myself in danger by increasing that further.
 
None of these NBOMe compounds are really safe at all compared to other psychedelics.

The real key if you want to remain alive and safe with these is to start low (500ug or less with each substance) and then work your way up in increments of 100-200ug, no more.

Why? Well look at the 2C-X series for example. Do you take 20mg of a 2C-X, decide that feels "not quite there" and double your dose to 40mg? Of course not, but people seem to be doing this with the NBOMes for whatever stupid reason - deciding 1mg isn't quite enough, and so they need 2mg.

I think it's due to the small dosages, people think "Well I'm only increasing the dose by 1mg", without realising that hey they're actually DOUBLING the dose.

So if you take 1mg and it's not quite enough for you, jump up to 1.1mg or 1.2mg - NOT 1.5mg or 2mg. That 100-200ug might not seem like a lot but it can make quite the difference.

That's also only if the drug isn't already producing significant vasoconstriction and other side effects. For example I feel like 1.2mg of 25C-NBOMe wasn't quite as strong as I wanted the experience to be, but would I up the dose at all? No way! My blood pressure was already too high from 1.2mg, I don't need to put myself in danger by increasing that further.

How long did it take you to reach a dose of 1.2mg 25C, out of curiosity? How many weeks/months did you increase your dose by 500ug to get all the way to 1.2mg?
Just wondering.
 
I agree with Jesusgreen, i had worse vasoconstriction on 25C than 25I, even if i didn't measure blood pressure the side effects were really unpleasant.
I spent more than 1 hour with extreme muscle tension, cold feeling, tremors with 25C, it was so unpleasant that i had to take xanax to calm down, while with 25I even at higher dosage i had far less.
For example with 25B i had no unpleasant effects at all and the strenght of the trip was comparable.
 
Yea, and do you guys notice these side effects at lower-ish doses of 25c like 600-800ug?
 
If you don't mind me asking what were your doses and ROAs for both?

ROA was always insufflation, sublingual didn't work well for me.
I tried them many times, 25B-Nbome from 700ug to 1.5mg max, with 25C from 600ug to 2mg max, 25I from 700ug to 2+mg, 25D from 1mg to 3mg.
In the last trial anyway it was around 600ug for 25C-Nbome after 2 weeks 1mg of 25I-Nbome.
 
How long did it take you to reach a dose of 1.2mg 25C, out of curiosity? How many weeks/months did you increase your dose by 500ug to get all the way to 1.2mg?
Just wondering.

I didn't. In my case I tried an allergy test dose and then jumped in at 1.2mg based on people telling me that I'd be underwhelmed by 1mg - it was a bad decision and not something I'd do now with hindsight, I'm just glad I didn't decide to dose higher or I may have put myself in real danger.

This is an additional part of why why I posted this, as one of the few people who originally told me that 1mg will be underwhelming for me later tried 1.2mg and found it the perfect amount - 200ug doesn't seem like much but it's like the jump from 10mg to 12mg of 2C-P, it can make a huge difference. They were suggesting I take 2mg+ but they too like me said after trying 1.2mg that they wouldn't go higher.

There are some people who've reported taking incredibly high doses of this and other NBOMe substances but in most cases it seems either a significant tolerance is involved or people aren't holding the substance under their tongue/on their gum for long enough before swallowing it - since these are inactive orally.
 
Safest NBOME?

so ya the nbome are supposedly a little dangerous (and i can definitely feel a little vasoconstriction on them) but i'm wondering which one is the safest, in terms of how high you can get without bad physical side effects. or in other words, at equivalent levels of intoxication/high, which one causes the least vasoconstriction/seizure risk etc.?

edit: also does DOC have less physical side effects than these?
 
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Unfortunately, it's completely individualized. I think this is becoming increasingly apparent as more and more subjective reports of the effects of various chemicals, including and especially NBOMes, are churned out.
 
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