Hey
@Ozymandeus 
First off, welcome to the forums man. We are lucky and happy to have you. In this day and age, junkies are being replaced by robots just like how Elon Musk replaced my children with robots. I can't complain, because my new children hear everything, even my thoughts.
I know you are new and you have opinions and beliefs you want to share. Like I tell a lot of folks on here, we really thrive only when we run entirely on facts and reason. I'm not saying life entire has to be about cold hard facts. This is often a life and death business we are dealing in, especially when it comes to our Opioid users. Regardless of what the information is, if it is not factually correct or if it is actually an opinion, we can't state it as if it is factual. That's how shit goes off the rails. Bluelight exists because in the before time, recreational drug knowledge was almost nothing but conjecture.
This place exists to give accurate information, especially in the Harm Reduction forums.
That being said, you've definitely dropped a lot of information in this thread. I understand you have done some reading and maybe have some opinions that you have formed based on said reading/personal experience. It's important to note that some of your arguments are not necessarily factually or a bit dubious.
Your argument that Opioid withdrawal is concerned more with Dopamine depletion than with the Opioid receptors is kind of an incomplete statement and almost erroneous and unnecessary for our discussion. It doesn't really serve to interject that statement and then argue it, when it is at best dubious and at worst just doesn't really make sense. I'm not insulting you either. I totally get where you're coming from with this. Yes, Dopamine is involved in many, many of the processes of the brain, our emotions and our reactions to drugs/withdrawal. You will find neurotransmitters like dopamine ubiquitously when discussing nearly any aspect of human behavior.
It is erroneous to say that the MOR is not responsible for withdrawal. I don't know what led you to make that statement, but you have to understand that it is antithetical to essentially everything that we know and understand about how Opioids work. It's okay to be wrong, but the fact that you're willing to argue the point further made me feel I had to say something.
Regarding the use of stuff like Agmatine for withdrawal...
You are showing the research stating it works. I will tell you right now that those research studies do not always reflect the real-world results, especially when there are real addicts with real habits involved. It is one thing to say that something "has a positive effect" and an entirely different one for a person in withdrawal to say "I felt great afterward". For a person in withdrawal, 10% better isn't good enough. 20% better isn't good enough and honestly, I know something like Agmatine isn't making a sick junkie any better than that 20% on a great day with pigs flying through the sky.
I have read plenty on N-Acetyl-Cysteine (NAC) and in fact take it myself, specifically to help with my Lupus symptoms among other hopeful benefits. I know that it, like Agmatine have been demonstrated to have positive effects on withdrawal among many other conditions.
Again, there is a major difference between something you take that will HELP you get better if taken daily and something that will make a person "well" or even "close to well". I can tell you, nobody with a severe habit ever had high-dose Agmatine/NAC relieve them of their withdrawal. I feel it's worthwhile to take as an adjunct as it might help lead to a better outcome, but these are not standalone treatments for withdrawal.
You throw a lot of personal experience and opinion in the mix. Someone who didn't know better who thought he could treat his Fentanyl withdrawal with Agmatine/NAC from the supermarket because he read it on Bluelight is going to be pissed.
I welcome you to the forums buddy. Please just be cognizant that people really depend on you, me and everyone else here to give them the best information we can. Take the time and think about your posts. I've made tons of mistakes here on Bluelight I can tell you about sometime over cognac and cigars.
