Imodium with kratom.

[Ozymandeus]

NAC/Agmatine absolutely helps in this regards but the problem is it kills any buzz I usually get from coffee, nicotine, pot etc for around 30 hours. I'm hoping this doesnt do that?

Agmatine is also a supplement I would highly advise for a lot of withdrawals. More effective for things like alcohol and benzo withdrawal but it also works for others.

NAC can also be highly useful, I just don't recommend it for everyone because like you mentioned, it has a long half life and will blunt the euphoric dopamine effect of most drugs. Also eventually feels like an antipsychotic if you take it daily and zaps any joy out of everything. Rather potent mood stabilizer on par with some pharmaceuticals.

 

[Ozymandeus]

Cannot imagine the degree of backup i would get on that combo.

It's quite awful. Particularly the bloating. And you feel gross. Way worse than constipation from high dose suboxone or something.

 

[WellTram]

Everybody is going to hate me but no, loperamide in doses lower than toxic for adult human won't potentiate anything except opioid constipation.
Loperamide is great tool for opioid withdrawals but it is definitelly not safe cns acting opioid ( well, it can be cns active but it has trouble to get into the brain ).
And in extreme doses it is surprisingly lethal. And not nice " nod and never wake up " kind of death. Cardiovascular issues.

 

[Kurt Cobain]

So i relapsed on kratom for 4 weeks and bought some imodium just incase i get mild withdrawals but it got me thinking does imodium potentiate kratom? Has anybody tried taking kratom after using imodium? if so what was your experience?

You're clearly young and opioid naieve and while you wont listen, keep it tuay way. Lope will not potentiate kratom. All potentiators people talk about are mostly bullshit for what we all intend it for. Kratom gives me withdrawls after one day of usage but ive also been an opioid addict since I was 11 and im now 28 so kindling effect plays a big role in that im sure. If youre worried about the wds find some habapentin or get some kava online and maybe take 20mg of lope for 3 days then stop but careful if you have issues with your heart at all I'd advise against the lope

 

[Kurt Cobain]

Never mind I just read your DLPA

Agmatine is also a supplement I would highly advise for a lot of withdrawals. More effective for things like alcohol and benzo withdrawal but it also works for others.

NAC can also be highly useful, I just don't recommend it for everyone because like you mentioned, it has a long half life and will blunt the euphoric dopamine effect of most drugs. Also eventually feels like an antipsychotic if you take it daily and zaps any joy out of everything. Rather potent mood stabilizer on par with some pharmaceuticals.

Augmatine does jack shit for actual withdrawls dude. Neither will dlpa maybe during the PAWS but not acute. I feel like youre just regurgitating what you read on reddit bc that's the only place I see people constantly mentioning these two specefically.

 

[Ozymandeus]

Augmatine does jack shit for actual withdrawls dude.

I respectfully disagree. It is a fairly modest effect, not something people should rely on for severe withdrawal.. it's not going to stop tremors, seizures, or feel like MAT. However it is palpably effective beyond placebo in my experience. Particularly for alcohol and benzo withdrawals.

This is not just anecdotal, and I am not regurgitating reddit shit either;

Inhibition of NMDA receptors by agmatine is followed by GABA/glutamate balance in benzodiazepine withdrawal syndrome - Beni-Suef University Journal of Basic and Applied Sciences

Background Drug withdrawal syndrome occurs due to abrupt cessation of an addictive substance. Dependence to diazepam can be manifested by withdrawal syndrome which may include symptoms such as irritability, psychosis, sleep disturbance, seizures, mood disturbance, and anxiety. Studies have...

link.springer.com

Agmatine: identification and inhibition of methamphetamine, kappa opioid, and cannabinoid withdrawal in planarians - PubMed

Agmatine blocks morphine physical dependence in mammals, but its effects on withdrawal signs caused by other abused drugs have been less studied. One of the reasons is that withdrawal to some of these drugs is difficult to quantify in mammals. An alternative to mammals is planarians, a type of...

pubmed.ncbi.nlm.nih.gov

Overall I found the pharmacological effect to be remarkably similar to Acamprosate (RX only), with agmatine being less selective and having a few mild side effects (mostly only noticeable in high or repeated doses)

 

[agoraphobe]

Augmatine does jack shit for actual withdrawls dude. Neither will dlpa maybe during the PAWS but not acute. I feel like youre just regurgitating what you read on reddit bc that's the only place I see people constantly mentioning these two specefically.

Not everyone is on the levels of drugs other people are on. For kratom leaf used every few days it does in fact make a difference. I've done it multiple times. If we're talking about someone cold turkeying a fent habit then yes you would be correct.