Imodium with kratom.

[Ozymandeus]

NAC/Agmatine absolutely helps in this regards but the problem is it kills any buzz I usually get from coffee, nicotine, pot etc for around 30 hours. I'm hoping this doesnt do that?

Agmatine is also a supplement I would highly advise for a lot of withdrawals. More effective for things like alcohol and benzo withdrawal but it also works for others.

NAC can also be highly useful, I just don't recommend it for everyone because like you mentioned, it has a long half life and will blunt the euphoric dopamine effect of most drugs. Also eventually feels like an antipsychotic if you take it daily and zaps any joy out of everything. Rather potent mood stabilizer on par with some pharmaceuticals.

 

[Ozymandeus]

Cannot imagine the degree of backup i would get on that combo.

It's quite awful. Particularly the bloating. And you feel gross. Way worse than constipation from high dose suboxone or something.

 

[WellTram]

Everybody is going to hate me but no, loperamide in doses lower than toxic for adult human won't potentiate anything except opioid constipation.
Loperamide is great tool for opioid withdrawals but it is definitelly not safe cns acting opioid ( well, it can be cns active but it has trouble to get into the brain ).
And in extreme doses it is surprisingly lethal. And not nice " nod and never wake up " kind of death. Cardiovascular issues.