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I Like to Draw Pictures of Random Molecules

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Why not? Also what if there were a vinyl bond at the alpha instead of the single on N?

Plus would Aminorex (and Phenmetrazine to be honest) act as PEA/Amp? Could you create aminorex analogues in the same way as amphetamine ones, such as 3',4'-MDO-4-MAR? I mean, it worked with 3F-Phenmetrazine; it's more potent and speedier just like 3-FA in comparison to Amphetamine.
 
I don't know why you can't have a non-cyclic, aliphatic N-C-O. It's just what I was taught and have noticed after looking at thousands of Kekule structures. As for the 3,4-MD-4'-MAR, yeah, I feel sure it would be active, and probably but not necessarily entactogenic. I would also bet it's more neurotoxic than MDMA and maybe even MDA.
 
Pemoline-version of 4-MAR and vice versa:
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Soulfake said:
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I came up with something similar to that last one recently and it should be going into production. The great thing is it's also UK legal, so expect it within the next few months. This is it:
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Whats with the methyl-1-keto-ethoxy bond though? I feel it'd only add to it's opioid properties and reduce potency but looking at the one before it seems like that's what you're going for.

Also any 4-MAR analogue will be neurotoxic and vasoconstrictive but that's the price to pay for a pretty incredible compound (4'4-DMAR was a bit of a wet blanket though). Just don't go too far and limit your usage and you'll be fine.

Oh and roi, that second compound won't work, it's got too long of an amine chain and there's really no need for that 4-methyl. 4-MAR is essentially amphetamine to aminorex's PEA, same with Phenmetrazine. The first might but looks weird.

Also soon to come is 2'-MMD-4-MAR, which, most likely, will blow a few socks off! If it's anything like it's amphetamine counterpart it should act as a psychedelic in some way but based on the 4-Methyl it'll reduce the HT2a agonism pretty significantly so I'm think just a very potent empathogen. As someone mentioned earlier the MDO bond would work but not as heavily as with MDMA so the 2'-MeO should push it up into that zone (in theory). I think a normal aminorex analogue would bring that psychedelia up a bit more but it'd lack the power of the 4-Methyl so I went with that instead.

Another on the way is N-Me-Lophophine-NBOMe. Not my idea but removal of the a-Methyl should activate it unlike MDMA-NBOMe made and tested by Nichols et al. There's also a series of very exciting psychedelics but I should keep shtum about those for the meantime!
 
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Oh and quickly what would the effects of 3-EtO-PCP be like? I'm assuming lower potency and maybe some altered DRI effects but I wouldn't mind a second opinion.
 
roi said:
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Did I get that right?
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You put the NBOMe as an extension of the N-methyl. That would yield a different name since it becomes an N-phenethyl instead of an NBOMe.
N-Me-Lophophine-NBOMe suggests that there is a tertiary amine, with a methyl substitution AND the NBOMe both on the N.

If that tertiary amine turns out active I will be amazed. Multiple wrongs usually don't make a right in SAR.
 
Whats with the methyl-1-keto-ethoxy bond though? I feel it'd only add to it's opioid properties and reduce potency but looking at the one before it seems like that's what you're going for.
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Yes exactly, I had a fusion of Tilidine and Fencamfamine (it´s basically nor-Tilidne with the cyclohexene replaced by norbornane) in mind when drawing it as they both have opioid and dopaminergic effects while nor-Tilidine is very short acting and Fencamfamine has a long half life (16h if I remember right))

I´m thinking about that molecule for a long time now, I have a feeling that it could be either great or inactive if the norbornane it too bulky for good opioid agonism.
 
Some fluoroamphetamines,,, These were inspired by the wonders of 4-FA, 2-FMA and FenFlurAmine.

RW7fXV3.png


Solipsis said:
You put the NBOMe as an extension of the N-methyl. That would yield a different name since it becomes an N-phenethyl instead of an NBOMe.
N-Me-Lophophine-NBOMe suggests that there is a tertiary amine, with a methyl substitution AND the NBOMe both on the N.

If that tertiary amine turns out active I will be amazed. Multiple wrongs usually don't make a right in SAR.
Click to expand...

N-Phenethyl tryptamines are active and potent.
 
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sekio said:
I suspect it'd be tasty. That and 3-EtO-PCE.



At least some of them are, but I'm not sure they've been assayed in man?

Also, the "wonders" of fenfluramine? Like the whole heart valve thing? 4-trifluoromethylamphetamine is known and isn't a "friendly" compund.
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Fenfluramine is safe and healthy unless you abuse it and take it every day, in which case it will probably give you heart failure. Stupid pharmacutical companies sold it as some diet pill which killed its reputation.
 
blueberries said:
The first is opposite. You need to turn the aminorex part around so the methyl is on the bottom and the second; the NBOMe is only a benzyl instead of the PEA.
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There's nothing wrong with the 2'-methoxy-3',4'-methylenedioxy-4-MAR structure. Due to free rotation of sigma (single) bonds, the methyl can be drawn up or down as long as the rest of the molecule is right.
 
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