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I Like to Draw Pictures of Random Molecules

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How about the nortropane analogue of fentanyl? I assume it's active, how is potency affected? 10x weaker maybe? That'd be good
 
Hammilton said:
How about the nortropane analogue of fentanyl? I assume it's active, how is potency affected? 10x weaker maybe? That'd be good
Click to expand...

Would it look like the first molecule?

l9trh7n6.png
 
Hammilton said:
How about the nortropane analogue of fentanyl? I assume it's active, how is potency affected? 10x weaker maybe? That'd be good
Click to expand...

I would look into N-methyl-3-carbomethoxy-4-(1-anilino)-tropane and N-PEA-3-carbomethoxy-4-(1-anilino)-tropane first. Also fentanyl minus the R-(C=O)CH2CH3 but with an R-(C=O)-O-CH3 [carbomethoxy] group instead.
 
The nor-tropane fentanyl is quite interesting! Some great novel concepts in the last page. I'm sorry for myself that I've been so busy I haven't the time to frequent this page as much.

Though of note, my Wikipedia article "List of Cocaine Analogues" is *Finally* completed. Check it out if you haven't this last month.
 
1-(3,4,5-trimethoxyphen-1-yl)-1-(N-methylpiperidin-4-yl)-1-(propion-1-yl)-amine.HCl
1-(1,3-benzodioxole-5-yl)-1-(N-methylpiperidin-4-yl)-1-(propion-1-yl)-amine.HCl
1-(4-bromo-2,5-dimethoxyphen-1-yl)-1-(N-methylpiperidin-4-yl)-1-(propion-1-yl)-amine.HCl
1-(3,4-dichlorophen-1-yl)-1-(N-methylpiperidin-4-yl)-1-(propion-1-yl)-amine.HCl
1-phenyl-1-(N-methylpiperidin-4-yl)-1-(propion-1-yl)-amine.HCl

These have the potential to be some seriously far out drugs.
I hope other people can read the nomenclature as I don't know how to post drawings.
 
It's still a tertiary amine, the n-methyl is removed (thus, nor) and replaced with n-phenethyl
 
Thanks, roi!!!

* * *

All of this series save for SHIVA (inspired by Sasha Shulgin's GANESHA) are fentanyl "based." Extreme dosing caution is advised.

N-(N-methylpiperidin-4-yl)-N-phenyl-(N-propionyl)-amine.png


N-(N-methylpiperidin-4-yl)-N-(1,3-benzodioxole-5-yl)-(N-propionyl)-amine.png


N-(N-methylpiperidin-4-yl)-N-(4-bromo-2,5-dimethoxyphenyl)-(N-propionyl)-amine.png


N-(N-methylpiperidin-4-yl)-N-(3,4-dichlorophenyl)-(N-propionyl)-amine.png


N-(N-methylpiperidin-4-yl)-N-(3,4,5-trimethoxyphenyl)-(N-propionyl)-amine.png


And, just for kicks:

N-(N-methylpiperidin-4-yl)-N-phenyl-(N-carbomethoxy)-amine.png


Finally, my personal favorite:

2-amino-1-(3,4,5-trichlorophenyl)-propane.png


SHIVA

For those who haven't read or don't remember GANESHA from PiHKAL:

2-amino-1-(2,5-dimethoxy-3,4-dimethylphenyl)-propane.png


GANESHA

The association was made because Shiva and Ganesha usually show up together in one form or another.
 
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The last one (3,4,5-trimethoxy-PVP) is supposedly coming soon.
 
what kind of activity are you expecting from the first two compounds? empathogen, stimulant?

edit: general question, could you guys recommend any ressources on the basics of (psycho-)pharmacology, SAR, etc.? I always wonder how you come up with these structures and why you choose certain groups/substitutions?
 
Memorize as many structures as possible, try as many as you can, read trip reports on the rest, and try to find patterns. It's an intuitive process. Also, read PiHKAL by Alexander and Ann Shulgin cover to cover. Finally, a degree in Chemistry doesn't hurt.

Chlorine Edition:

4-chloro-3-(2-dimethylaminoethyl)indole.png


5-chloro-3-(2-dimethylaminoethyl)indole.png


4,5-dichloro-3-(2-dimethylaminoethyl)-indole.png


2-chloro-3-(dimethylaminoethyl)-indole.png


1-amino-2-(3,5-dichloro-4-methoxyphenyl)-ethane.png


1-(3,4-dichlorophenyl)-2-methylaminopropane.png


2-methylamino-1-(6-chloro-1,3-benzodioxole-5-yl)-propane.png


2-amino-1-(7-chloro-1,3-benzodioxole-5-yl)-propane.png


Plus two oddballs:

2-amino-1-(2,4,5-trimethylphenyl)-propane.png


2-methylamino-1-(3,4-di-oxocyclohexyl)-propane.png
 
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