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I Like to Draw Pictures of Random Molecules

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thenightwatch said:
^ "far less potent" isn't necessarily a bad thing, considering that the NBOMe-phenethylamines are active in the sub-milligram range
Click to expand...

I believe that alpha-alkylation of psychedelic N-benzyl-PEAs causes them to act as antagonists/weak partial agonists at 5-HT2A/C, so potency is kind of a moot point. They might be a starting point for selective 5-HT2A/C development a-la ketanserin, but recreational compounds they do not make. I have a feeling that they are probably too bulky to act at the SERT/DAT/NET as well, at least as releasing agents, so N-benzylation of MRAs is probably a non-starter as well...
 
I think that we could have methadone analogues that wouldn't bind to NMDA receptors as I'm sure that NMDA antagonism is responsible for the zombifying effect of methadone. Either substitute the phenyl ring(s) to lower affinity for NMDAR or lengthen the alkyl chain attached to the carbonyl. I'm wondering why this is not researched. The quality of people's life could be so much better. Even if it was less potent than methadone, it'd be a good thing, perhaps an analogue with more substitutions that would boost the potency.
 
Here's the next wave of molecules. Most of them are fictional stimulants. Some novel fictional psychedelics will be next.
Here's AX-1
4qps0x.png

Here's AX-2
jajatz.png

Here's STM-200
kf39j7.png

Here's STM-200-M
208i33q.png

Here's STM-201
35mnwvq.png

Here's STM-201-M
i290r9.png

This is Z-238
nc1dl0.png

This one's XTVA and it should have similar effects to MDA
2cgosau.png

Here's ZXQ-STM
2rrav60.png

Here's ZXQ-21
347y4r7.png

Here's ZXQ-22
16kykpc.png

Here's ZXQ-22b
2dayv6r.png

Here's STM-202
21k02lx.png

Here's ZXQSTM-238
s5jy35.png

Here's XTZ-101
nxp1n8.jpg


Here's 3,4-MethyleneDioxyHydroxyEthylAmphetamine, or MDHEA. I wonder if this one's even active though. I hope so.
14m7sx5.png


More molecules coming soon.
 
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before asking this, i'm well-aware this doesn't vibe w/ this thread's purpose... but i figure th eminds here could elaborate and help me to understand.


I read about non-commercial, non-distributed, highly dopaminergic drugs (the RT series, ie rt55, to be precise), and am just wondering why such compounds haven't jumped into the marked, either as cuts to coca product, bath salts products, or any combo thereof. The pharmacological data from the rti series of dopiminergics is 'promising', w/ respects to DAT hijacking / minipulation, so why on earth are they now available* drugs right now (*I'd note that, based on a rudimentary understnading, they're probably more dangerous than based coca or mdpv, but, let's be real, that won't give a pause to an RC vendor, so why haven't we seen a lot of the RTi series set for the rc market?
 
adder said:
I think that we could have methadone analogues that wouldn't bind to NMDA receptors as I'm sure that NMDA antagonism is responsible for the zombifying effect of methadone. Either substitute the phenyl ring(s) to lower affinity for NMDAR or lengthen the alkyl chain attached to the carbonyl. I'm wondering why this is not researched. The quality of people's life could be so much better. Even if it was less potent than methadone, it'd be a good thing, perhaps an analogue with more substitutions that would boost the potency.
Click to expand...

Isn't methadone's NMDA antagonism valued though, as a way to mitigate tolerance build?
 
Fake NZT molecules from the movie limitless.

In the end, Eddie Morra creates NZT-49 (nootropic), leaving NZT-48 (fake nootropic) obsolete. NZT-49 permanently boosts cognition to a four digit IQ and is non-toxic. Continual use may even lead to a 5 digit IQ. Such a hightend intelligence would effectively lead to the cure for certain cancers and even the creation of new elements. Such elements would be in the "island of sability" and allow the person to become nearly indestructable.
The alternate ending is scarier. There's no NZT-49 in the alternate ending, only NZT-48. NZT-48 only temporarily boosts cognition to a four digit IQ. The toxicity is speculated to come from the thallanyl (thallium based) molecule. Such an error leads to fatal toxicity and permanent brain and body damage. Thallium also causes extreme sickness and death. Death! Thallium is HIGHLY toxic!

Here's NZT-48, or thallanylzirconio-methyl-tetrahydro-triazatriphenylene.
afaw61.png


Here's NZT-49, or phosphanylzirconio-methyl-tetrahydro-triazatriphenylene.
1sb6o2.png


Here's the ending of Limitless where he makes NZT-49 in the end.



Here's the ending of Limitless where he's stuck on NZT-48 and didn't create NZT-49.



Hypranootropics(super nootropics)
Nootropics(permanent cognitive enhancement)
Quasinootropics(temporary cognitive increase, little or no brain damage)
Pseudonootropics(fake nootropics. The effect is temporary and there's extensive damage, toxicity, and a host of side effects including high addiction potential, blackouts and brain damage)

I wonder if near indestructability and NZT-49 would ever become real possibilities. That would be so cool! :D %)
 
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why do we need to post fictitious compounds in a forum discussing real drugs.

good luck making a thallium (III) hydride under any earthly conditions. or even any organometallic compound with a Zr-Tl bond.

Thallium is HIGHLY toxic!
Click to expand...

thallium(I) is, thallium(III) is much less so. i would be more concerned about the phosphine that would be released from hydrolysis. or the fact these are triazines and will probably decompose releasing nitrogen or ammonia or some other nastiness. or the fact they're polyaromatic aromatic hydrocarbons. or that transition metal organometallic compounds have a tendency to explode into flames in the air. or on contact with water.

so yeah, fictitious compounds are fictitious. some of the stuff you draw in the random molecules thread are more plasuaible as a drug than this ever would be.

and i'm not sure i follow how having a superior intelligence means you can create new elements. we know damn well how to do that, we smash elements into each other. the problem is: atoms are fucking small, and particle colliders are comparatively expensive and kind of require their own power generating stations dedicated to them. we're not limited because we're not smart enough, we're limited because physics always makes us look like a bitch.

i know i'm just a big bundle of fun wet blanket but ... i'm also a chemist? and again this is supposed to be a forum about real drugs. otherwise this devolves into a wonderful discussion of the pharmacology of redeye (c.f. cowboy bebop).
 
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SkyblueMolly said:
I don't know what forum this belongs in. Is there a forum for fake molecules? Maybe I want NZT-like compounds to exist and to obtain them too badly.
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You should be glad that shit doesn't exist.
If you had a few people that had 4 or 5 digit IQ's you'd end up with a singularity and then all bets are off...
So if that shit ever gets invented you better hope to hell you are on the short list for a dose.
 
p8bFKbM.png

Originally i wanted to design a morphine based psychedelic - but settled on phenanthrene instead. The one on the bottom is a double 2cb connected at the N position. The one next to the phenanthrene one is based off ethylphenidate/amphetamine/mdma but with a lot of amide groups. I know the double 2-cb wouldnt be active, Im not even sure that amide group could be reached by a receptor if the giant chemical passed the BBB. I honestly wonder about the other 2.

I call the phenanthrene one BTOMPA - Bromo -TriOxyMethylPhenanthrenamide
and the weird amphetamine Beta, 4 oxy phenethylamine methyledioxyamideamphetamine

Edit: I actually really wonder if the phenanthrene based compound would be active?
 
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Anbybody got any thoughts on whether this would be active? Sorry if someone else has posted this before.

Iyr0.png
 
Here's more molecules.

Here's furanylpropamine, or 1-(furan-2-yl)propan-2-amine.
5d19wh.png

Here's 5-iodo-MDEA, or 5-iodo-3,4-methylenedioxyethylamphetamine.
96l1kz.png

This molecule is called "mega awake death!". It's a hypothetical wakefulness enhancer witch will keep you awake for OVER 9,000! hours even after you die(you'll literally be dead and yet have your eyes awake).
izxrpg.png

Here's bipyrene. It's a hypothetical stimulant that is a hybrid of 2-amino-indane and Z-17.
2s9u71y.png

This one is a hybrid of desoxypipradrol and fluorenol. Professor scweak, or squeek. It's a combination eugeroic and stimulant.
16itgs5.png
 
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Not sure if this has already been posted:
eMQBDAh.png


2-methoxy-4-ethyl-5-methylthio-phenethylamine

Were this or related compounds ever tested? I know that replacing one methoxy with an ethoxy works.
Would seem like an obvious way around various drug laws..
 
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