• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

I Like to Draw Pictures of Random Molecules

Status
Not open for further replies.
Cool new made-up molecule. Hypnofluorenol!
ixgk91.png

This one is 2C-TAC.
fwos44.png

Here's BZR, or BenzylRacetam.
2ahwk21.png

Here's 2C-T-2m2b.
5ufgud.png

Here's 3-MTA, or 3-MethylThioAmphetamine
x0qmia.png

Here's WTS-989.
6pvts5.png

WTS-5CXA.
10xrevn.png

Here's NZTX-542.
2ecf4ef.png

Here's 2C-CM, or 2C-MC.
20k6ce8.png

This one is indanetraline.
24v901f.png
 
Last edited:
sekio said:
So, why not carborane-JWH? (actually, carborane-AM2201) It should be promising given what we know about SAR at the cannabinoid receptors.
EIHXXdM.png
Click to expand...

Won't bring anyone's mother back but you'll be too stoned to care.

I like it.

















*there's a reference in there for those that didn't get it
 
"WTS 5CXA"

ZOMG, No no no with that aziridine in the PEA-like structure!, Its even more reactive than an epoxide!
(Eg... It reacts and covalently bound with any unselective tissue!)
 
Would it polymerize in a chaotic way? Can't that kind of reactive chemical react with parts of itself?
 
It should polymerize to a black gum... But not insomuch chaotic way

A nucleophile will kick-start the ring opening polymerization... Getting more NH2 "opened" and becoming a nucleophile.
Other parts of the molecule shouldnt affect this, thioether should be stable enough until runaway heating occurs.

And yes the leftover will attach to the body ;)

Btw, i do like the carborane one of sekios above! It isnt too far from what is required (bulk, somewhat hydrophobic). Idk if its stable in vivo tho!
 
Here comes another wave of made up molecules. This time, it's mainly stimulants.
Here's AX Jr. It's based on aminorex.
23r7pqe.png

Here's B-PhenylAmphetamine, Beta-PhenylAmphetamine, or "super speed".
qsqd0m.png

Here's B-PhenylHydroxyAmphetamine
jajej6.png

Here's B-PhenylSelegiline.
fnv5lc.png

Here's MDMPG, or Mindormeprag. It's an experimental treatment taken daily for Parkinson's.
2nrojyh.png

Here's EA, or EthylAmphetamine.
6pwb6a.png

Here's 2-methyl-2-butylphenidate, or 2m2bPhND.
33v2rlf.png

Here's Methylcyclopentanidate.
25khmhc.png

Here's NRG-64, based on desoxypipradrol.
2ymg6yd.png
 
Last edited:
Nice ones :D
Pretty sure some of them like the beta-phenyl amphetamine seem very familiar, like I'm pretty sure it is a known compound. But I don't mean that as criticism, more like: you got a point coming up with it. Actually hoping for a regular to point out existing info on some of them cause I can't really find it.

I am curious about how ethylamphetamine (crystal eth? lol) would differ pharmacologically, if it is mostly less potent or if there is a shift in which monoamines are mostly affected. I gotta say that ethcathinone is kind of shitty (it emphasizes on NE release IIRC?) but not sure how it compares analytically to methcathinone...

Does anyone have a link for some good stim SAR discussion? I think alpha-alkyl chain makes something increasingly dopaminergic for example, what about N-substitution, etc? And 4-substitutions can have effect on serotonergic qualities while 2-substitutions are more for dopaminergic qualities? etc I may be off but it would be cool to get some clarification...

The aminorex one would have to be aromatic I think (so cyclopentadiene) to be more accurate..
 
I am curious about how ethylamphetamine (crystal eth? lol) would differ pharmacologically
Click to expand...

IIRC, it's less selective for NE over DA than meth, and slightly more serotonergic. Nice stuff, but less potent than meth, similar potency to perhaps amp itself, maybe less.

I gotta say that ethcathinone is kind of shitty (it emphasizes on NE release IIRC?) but not sure how it compares analytically to methcathinone...
Click to expand...

It's entirely selective for NE, except for some direct adrenergic affinity and metabolism to cathinone.

I think alpha-alkyl chain makes something increasingly dopaminergic for example, what about N-substitution, etc? And 4-substitutions can have effect on serotonergic qualities while 2-substitutions are more for dopaminergic qualities? etc I may be off but it would be cool to get some clarification...
Click to expand...

It's a bit tricky to come up with a good theory in aggregate, particularly as the effects of some substitutions depend on the configuration of other substitutions, especially with the beta-ketone substitution. SAR becomes pretty different moving from releasers to reuptake inhibitors.

ebola
 
SkyblueMolly said:
Here comes another wave of made up molecules. This time, it's mainly stimulants.
...
Click to expand...

Awesome! Keep up the good work dude!

Something to keep in mind when designing something like a stim, if you replace the main aromatic ring (benzene, thiophene, etc) with something non-aromatic, you will almost certainly lose affinity for the DAT and SERT, leading it to have mainly (nor)adrenergic effects. It is possible to have indirect DA and 5-HT releasing properties a-la propylhexedrine, but its just as likely to be something akin to methylhexanamine. Far be it from me to tell you what to draw, but I think AX Jr. and methylcyclopentanidate with a thiophene ring, or even possibly a furan or pyrrole ring, would be VERY interesting!
 
Last edited:
N-ethylamphetamine is also a Schedule I drug, which makes getting ahold of any more difficult.
 
(1) Alexander Shulgin has already made and bioassayed thiomescaline.

(2) Does anyone else think that N-(2-MeO)benzyl-MDA would make a great 'legal' research chemical?
 
thenightwatch said:
4-thiomescaline looks like a total winner, idk why its never made the rounds
Click to expand...

I completely agree. I've wanted to sample it for some time now. A few years back someone I know was going to synth it, but nothing ever came of it in the end, his excuse was that some intermediate was too impure to work with and too difficult to purify I think he just couldn't be arsed to bother and made up some bullshit.
 
Dresden said:
(1) Alexander Shulgin has already made and bioassayed thiomescaline.

(2) Does anyone else think that N-(2-MeO)benzyl-MDA would make a great 'legal' research chemical?
Click to expand...

I think someone made it, tested it, and decided it was crap/inactive
http://www.bluelight.org/vb/threads/589711-MDMA-NBOMe

As mentioned in the last post a-alkylation is a no no for NBOMes, so you'd assume MDPEA-NBOMe would be quality. I think I remember reading this was also bioassayed and decided goddamn awful, but i can't find a link to back that up.
 
That may well be true, but I know that baseball players in the 1960s and 70s used to take little green prescription pills called 'Greenie Meanies' before big games. The active ingredient was N-(2-chloro)benzyl-amphetamine, a molecule with an N,alpha carbon.
 
pills would suggest they ate them, right? We don't know for sure, but assume that there's cleavage at the N which in that case would leave just plain old amphetamine. Unless they're snorting them or something, it's not the N-(2-Cl)Bn- part that makes the effects.
 
That's clobenzorex, an amphetamine prodrug, sort of similar to benzphetamine. Both are long lasting "extended release" prodrugs for amphetamine. The liver cleaves it to amphetamine.

People have investigated NBOMe-amphetamines, but they're far less potent than NBOMe-phenethylamines. So NBOME-MDA is probably a loser.
 
Status
Not open for further replies.
Top