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N&PD Moderators: Skorpio
How toxic is Mephedrone?
- Thread starter Giovanni
- Start date
Cannabis is class B. There was no evidence (and still isn't) that Cannabis is toxic.
ebola?
Bluelight Crew
I'm a Yank, from the land of hasty drug prohibition and geographical myopia.
Hey. I have a question regarding the beta ketones and Mephedrone in relation to them.
I've now tried Mephedrone, Methylone and MDPV a few times and for some peculiar reason. I have heart pain after using MDPV and Methylone yet Mephedrone does not cause this. I also do not get numbness on Mephedrone but DO get it on Methylone and MDPV. Of course I understand Mephedrone is renowned for the toxic effects like these and as such I am confused why I get them on less toxic substances but not the "worst".
My heart also beats less rapidly on Mephedrone than on Methylone/MDPV. Is mild chest pain common after Methylone/MDPV usage? Is it common after Mephedrone usage?
Would appreciate opinions.
vortex30
Bluelighter
Chest pain after MDPV is a huge issue for me especially if re-dosing regarding chest pain. Methylone, I've never had a problem but my Methylone sessions have been a single dose, most was 250mg. As for Mephedrone, I reckon a small session of 250-300mg wouldn't cause much issue, but when I do 1-2+g I can really feel the strain on my heart. So are you binging the mephedrone?
I've never exceeded 800mg in a session of Mephedrone. I'm on it for the first time in about a month at the moment and have not had any indications of vasoconstriction like I do on even low doses of MDPV and Methylone. I suppose these drugs affect my body differently to most people.
Tonight I've probably had about 500mg so far and am just about to have my last dose for the night. Will report anything interesting.
Coolio
Greenlighter
- Joined
- Feb 29, 2004
- Messages
- 6,938
The vasoconstriction paranoia is pretty ridiculous to be honest, it's all you seem to hear about slightest pins and needles and it's panic stations, geez everyone gets pins and needles from time to time and cold feet ? It's the coldest sodding winter in 31 years in the UK.
Uh, no. If you get pins and needles from time to time, you probably need to see a doctor. That's a sign of poor circulation and you may have cardiovascular health issues. Healthy people NEVER feel that unless they cut off blood flow to a limb by sitting on it for a while.
Umm... pins and needles (Paresthesia) can be caused by many things, not just poor circulation.
I have had frequent numbness, paresthesia, itching, crawling sensations in right thigh / groin area for years. Had many visits to my GP and many tests, including an MRI scan, and everything is negative. In the end, my GP just said that it is probably just how I am built. In other words, he didn't seem too concerned about it!
MattPsy
Bluelighter
- Joined
- Jan 15, 2006
- Messages
- 1,615
Destruction.
Haha, well maybe.
WHICH synapse? A GABAergic one? A dopaminergic one? A serotonergic one?
The first statement might be correct in regards to a serotonergic one, since mephedrone shares a similar method of action with MDMA, and GBL probably increases neurotoxicity with MDMA due to higher dopamine levels leading to oxidative stress during MAO destruction.
I would have thought so, but as mentioned in the post regarding Ginkgo Biloba, it will also dilate the blood vessels in the brain, maybe leading to an increased risk of neurotoxicity from the dug.
Dont think they did any tests on MDMA did they?
This stuff i got was called 4-methylmethcathinone (4-MMC)
Is this not Mephedrone? I thought it was was mephedrone and slang for it is MCat. Clearly its methcathinone, not mcat
Is Methedrone differenet to Mephedrone?
How does Mephedrone differ to the stuff i have been taking - Methcathinone?
The website I bought the stuff off says 'Buy Mephedrone plant food online' What arrived says '4-methylmethcathinone (4-MMC)' on it?!
Confusing!?
nolys
Bluelight Crew
yeah mate 4-mmc IS Me(p)hedrone, not me(t)hedrone. They are 2 seperate drugs
Hurrah for the media! 8)
Which reminds me... has anyone seen this yet? Comments? http://www.youtube.com/watch?v=HJnr8b526o0
rpm
Bluelighter
Er, that would have to be nonsense or spin. If drug laws where based on toxicity then .....![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
Dresden
Bluelighter
- Joined
- Feb 2, 2010
- Messages
- 3,212
Mephedrone is more toxic than acetylsalicylic acid, ibuprofen, naproxen sodium, docusonate sodium, sodium bicarbonate, sennosides, diphenhydramine, and dextromethorphan but less toxic than isotretoin, haloperidol, quietiapine, olanzapine, sumatriptan, prednisone, seconal, alpha-methylsufentanil, oxycodone, and thalidomide.
The most common side effect is a reversible headache and occurs half of all users of the drug. Its most serious cosmetic side effect is vasocontriction of the blood vessels of the body's extremities causing them to turn blue temporarily; this side effect occurs in about 15% of users. Idiosyncratic sudden death of the mdma type occurs at about the same rate as seen with that drug (approximately 1 death per several million usages or so).
