spacefacethebassace
Bluelighter
Hooray, we can all go back to using real drugs. Meow
/apologies for pointless post
/apologies for pointless post
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N&PD Moderators: Skorpio
How toxic is Mephedrone?
- Thread starter Giovanni
- Start date
ebola?
Bluelight Crew
mmm...I don't think that naph' will qualify as an analogue of methcathinone...nor will it for 4mmc...too bad it appears to suck.
Nagelfar
Bluelight Crew
Is this to put that 'NO SOURCES - nuke' out of business? They'd be wise to open their registration for the final month of one of their main products (maybe all of their products?) and take advantage of making the profit they may never get back (or take the last of whatever profit they may ever have)Last edited by a moderator:
Hurrah. Now we can go back to being criminals again... 8)
I don't get this almost snobbish attitude to meph that seems to be noticeable in a number of posters on here... people saying that they are glad it's being banned and treating the substance and its consumers like a lower-class drug users.infestedpasta
Bluelighter
- Joined
- Feb 1, 2007
- Messages
- 137
theotherside
Ex-Bluelighter
^^^^^I agree. Mephedrone is an amazing drug as far as I'm concerned, despite it being cardio-toxic, I can't stand how it is treated on these threads. Why would anyone want someone's right to have a beautiful substance delivered to their doors is beyond me.
dread
Bluelighter
Mephedrone is absolute shit and everyone would be better off if it would never have been invented, in my honest opinion.It's not absolute shit in the efficacy of a high sense. It's a very potent entactogen. It's popular because it's good. Unfortunately it's probably unhealthy but that doesn't make a drug shit instantly. It's probably a little more toxic than alcohol at the rate of sensible use (IE 500mg once a week) compared to 21 units of alcohol a week.
I enjoy the high. It sucks it's getting banned objectively. But subjectively it's a good thing, I use it too much.
Also, yes, all the cathinones that are popular are getting banned. Even Buphedrone is getting banned.That the high out of meph is amazing I can agree on but that is slightly more dangerous than alcohol I can't help but say that it's absolute BS. I've never seen any bad reaction like purple knees and heart issues after a few drinks, which is the equivalent of a responsible and moderate meph use. I should probably say that I've never seen such bad reactions after a responsible and moderate use with any drug, but I don't feel I have enough of experience with drugs to say that.
Then, my personal opinion is that anyone is free to do whatever he wants with his body, you can also eat cyanide trying to catch a high if you like, I'd still have nothing against it, but please don't say "meph is not that bad".
SpiritualHealing
Bluelighter
Honestly I know about 20 4-MMC users of different age and gender and none of them ever had purple knees or heart problems even after consuming up to - or over 1 gram of it. On the other side I know more than 50 persons which puked after drinking too much and had weird side effects the next day. I also never heard of a girl that has been drug raped after taking 4-MMC. But nearly all "normal" rapes happen to girls after getting drunk. Sad enough that newspapers just write about GBL/GHB as the "date rape drug no.1" but not about alcohol. Alcohol is one of the main reasons for cancer disease and other health problems... and it´s also very addictive. Sure 4-MMC may be more addictive but the primary side effects aren´t as weird as with a high dose of alcohol.
SpiritualHealing
Bluelighter
I don´t want to relativize the danger but people should consider this when talking about toxicity of drugs in general.Anybody have any idea about how effective a low dose of Codeine would be to battle vasoconstriction? I've heard that Codeine is a peripheral vasodilator.
On a slightly related note. It appears that even a small dose like 150mg of Mephedrone will give my knees a slight purple hue with noticable redding. It appears to be an affect that aggregates over time because I've never had this before. It could just be because I've moved house and this house is considerably colder, but I'm not sure how much temperature would be implicated.Okay I'm done with Mephedrone. I was by no means a reglular user. My cumulitive dosage over 3 months is probably just shy of 8grams but it's undoubtedly done me harm. My resting heart rate has gone from a healthy 60bpm to about 88bpm and I dread to think what it's done to my BP. A 220mg dose just gives me slightly purple knees and bronchodilation. I'm barely even stimulated at this dose yet vasoconstriction still raises it's ugly head.
I really do warn people that this substance is insidious unlike anything else. The first times are great but now it just is buzzless, barely stimulating and just an anxious ride the whole way through. I hope my health returns to normal soon. Note that my RHR was 60bpm even after I consumed my first 5grams, I believe a bad synthesis may have contributed to my last 5 grams yielding little effect except vasoconstriction.
OK, I had to look it up: bronchodilation - a widening of the lumen of the bronchi, allowing increased airflow to and from the lungs.
How do you know this happens?
Simply put, breathing becomes markedly easier and rather pleasant. It occurs with all stims. It's what epinepherine does for asthmatics.slackhands
Bluelighter
- Joined
- Mar 11, 2010
- Messages
- 169
No offence but you sound like a little queer. Also you contradicted yourself on your previous alcohol/meph comment. Just dont like people who write bollocks really; nothing at all personal chap.
slackhands
Bluelighter
- Joined
- Mar 11, 2010
- Messages
- 169
Dude, ffs you've only done 8 grams. If anything it takes someone a few times to take a drug to get the benefits. Well this is true for me haven taken a whole array of different drugs.
I think you jump to conclusions far too quickly. It sounds more probable that the bad synthesis you suspected, would be why you believe meph to be insidious
BTW 5+5=10 NOT 8 grams!!
lenses
Bluelighter
From what I understand from experience reports about MEPH, it seems that the main problem is the very strong vasoconstrictive properties.
Personally that is my main problem with stimulants, when I was very heavy into adderall and dosing 200+mgs a day just to get by , the comedown was horrible because of the breathing problems, to the point where it was very uncomfortable to stand up, I had to lay down to breathe well.
The intensity of the MEPH vasoconstriction seems the worst of any stim i've heard of . I would stay away.
-lenses
ebola?
Bluelight Crew
^^^^
aye/hear hear/etc.
Qualitatively and quantitatively, mephedrone is especially dangerous (this will just recap prior posts from various people). First, mephdrone appears to present greater cardiotoxicity than other stimulants that we typically consider among the most dangerous recreational drugs, ie cocaine and methamphetamine. While the main danger (vasoconstriction) might not be the same, particularly with meph's issues versus cocaine's calcium-channel blockage, the incidence of adverse reactions and even the couple deaths on record with a drug this new, lacking as large, long-term, and 'dedicated' user-base is particularly alarming.
What is more, mephedrone's particular pharmacology and phenomenology lends itself to extension into toxic situations. That the 'main', desirable effects are so fleeting, and relatedly that the compulsion to redose eclipses insufflated coke for most people, yet the duration of action of the toxic metabolite(s) lasts a few to several times longer, makes dangerous use likely.* I mean, even first time users usually breach an ample 250 mg, and many even hit a gram+ in a sitting.
While I think all recreational drugs should be legal, banning mephedrone should reduce its incidence of usage compared to safer alternatives.
*IIRC, mephedrone has been confirmed to metabolize into 4-methyl-ephedrine, in rodents and humans too. Also, other research suggests that 4-halo-ephedrines (which should act very similarly) to exert potent vasoconstriction, metabolize comparatively slowly (half-life of four to several hours, IIRC), and have a therapeutic index 3 times worse than ephedrine (all info from research linked by vector).
ebola
