I have provided quite a few articles that show multi day use to be safe under the right circumstances. Also the article you’ve provided seems to be only available as the abstract in the link unless I need to search further?
To answer some of your concerns,
1. All studies that show long term abnormalities used large doses in a binge dosing type scenario often 20mg/kg every 2hr 4x total. It should be noted there is no long term serotonin deficiencies of any sort when a single dose is given even up to 20mg/kg. It should also be noted the studies most often cited for these long term primate serotonin deficiency is a Ricaurte which should be thrown out instantly if one is familiar with his work.
Let’s look at some of studies supporting long term neurotoxicity in primates…
Probably the most cited.
We have a Ricaurte article but we see that they use multiple doses of 2mg/kg at 3hr intervals. Most MDMA users know of the diminishing returns and heavily increased comedown that come with this dosing. This would be like me taking a full solid dose 3 times in a night, a guaranteed disaster.
What people also love to forget is that of the 5 squirrel monkeys, 1 couldn’t stand the 3rd dose and the other died! Last I checked humans try to avoid dosing regimens which induce death in 1 of 5 individuals.
Another popular one, this one I’ve often seen people quote these are actual human brains.. Drug war huh.. This one you’ll need to search out the PDF it’s out there.
Here we see 2x5mg each day for 4 days!! Once again similar to human doses but the only way they can get that neurotoxicity is through a multiple dose a day regimen, as shown in other articles a single dose daily doesn’t have the same neurotoxic potential.
Now the only article which seems to imply “long term” neurotoxicity from a single dose of 5mg/kg orally. First off that’s double an average dose at least. But next we see long term to then is 2 weeks post dosing.. Also yet ANOTHER Ricaurte.
I’ll be honest if you can find me an article that gives primates a reasonable single oral (2mg/kg) that then checks at least 3 months later, I’ll start to think twice but based on everything I’ve provided both in support as well as debunking research that is against i feel fairly confident in my assertion.
2. This I will agree does show cause for concern with neurotoxicity. My retort on this is that these studies were done long before MDMA users were wise to how to use MDMA properly. I never claim this drug should not be treated with respect, quite the opposite. Back in the day (90’s and 00’s) weekendly use was common, sometimes both nights.
I have also talked about on a number of occasions when one is noticing a tolerance increase that is a sign based on the research that one is getting neurotoxicity from the MDMA. This is why folks should read my thread about How To Not Lose The Magic, goes over all this and more.
Both myself and numerous close individuals to me have dosed how I describe with zero tolerance increase even after over decade of use.
3. Yup there is many proposed neurotoxicity mechanisms, all of which (besides maybe excitotoxicity, I’d have to look) are attenuated by ingestion of antioxidants. No matter how it occurs, or whether it occurs via multiple mechanisms it all comes back to our antioxidant system. MDMA taxes this system about 400% normal so one must make sure to ingest higher than average antioxidants during that time.
Again I don’t claim this to not be an issue, in fact I mention this as the biggest thing people need to keep an eye on. Each subsequent roll will drain it further, so one must top it off often as they can and consume a healthy diet with a large variety of said compounds.
Regarding the heat, yes this is also a concern. But this goes back to my How To Not Lose The Magic thread, I talk over that more there and don’t think it has much to do with this current topic.
I’ll finish with this, I hold MDMA sacred as well. There’s been years I’ve only taken it once or twice a year. I hold true to the idea one must keep a strict yearly limit (not necessarily x4 or less but definitely no more than x7-8). MDMA has given me probably the most insightful experiences of any drug I’ve tried including psychedelics. I don’t view consuming two days in a row hedonistic or in any way disrespectful, quite the opposite. Ask
@Hilopsilo about the magic that is two day dosing, I’ve been able to reach heights I don’t feel I could’ve done in one session.
-GC