Pill2Chill
Bluelight Crew
Well, IIRC salvia is a kappa-agonist. Pentazocine is as well. Both of these substances cause me severe dysphoria. From those personal experiences + the info I've read about KOR (Kappa Opiate Receptor) online, I'd say it's quite possible that many (if not most) kappa-agonists can and will cause dysphoria. To my knowledge, Delta-agonism has no direct link to dysphoria.NET/SERT affinities are less of a concern to me than any Kappa/Delta action alongside my Mu-derived pleasure - is there any of the dysphoria such action leads to?
![]()

OT: Just woke up after a few hours sleep, still feeling the opioids rather strongly, but I'm not really nodding anymore. Gonna go smoke a cigarette in a minute and see if that brings back the nods a little, it just might.

/e: That actually did it, nodding again. Sweet!

Last edited: