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How High Are You? v. Well I'm Pretty Darn High

550 mg codeine and 2 grams of phenibut. The break I took yesterday went a long way to enhance today's high. Feeling wonderful. Such a shame that codeine's high is short-lived. Could be in this state for days.

Anybody else get insane munchies when on a low-strength opioid high? It's like clockwork for me lately. 30 minutes after dosing I'll be stuffing my face like there's no tomorrow.
 
Methacodone said:
Don't mean to rub it in, but I'm very impressed with Carisoprodol. It ALMOST feels as good as Diazepam, but not quite there. Give me Diazepam all day long over Carisoprodol.
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Diazepam > Carisoprodol without a doubt!

Just went to my court-ordered bupe program, and THC and BZD's/clonazepam didn't even pop hot. I took k-pins yesterday and smoked this morning, not to mention high-grade cannabis. My urine must be looking out for me hahaha.
 
Just coffee-ing

I want to smoke weed and drink but it is too early and I'd only be more useless.

Edit: drinky time! Gotta get food and more drink soon.
 
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Pill2Chill said:
^IM ampoules exist. So IM injection is possible. I've tried it a few times, and it has a noticably higher BA. The nature of the effects are the same as with oral though, oral just requires a somewhat higher dose. Overall I'd say IM isn't worth it though, oral is the best RoA for tramadol IMO/E. I don't know about plugging, but I think it might be less effective due to the first-pass effect being skipped. I may be wrong about this though, so don't quote me on it.
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Tramadol has a higher affinity towards SERT (Serotonin transporter) and NET (Norepinephrine transporter) than it has towards the opioid receptors, but a large part of it is metabolized into O-Desmethyltramadol, which has no (noticable) effect on Serotonin (I don't know about Norepinephrine) and way stronger opioid affinities. In layman's terms: Tramadol is a weak opioid with SSRI properties, which's effects are mostly felt when skipping the first-pass. O-Desmethyltramadol is the major metabolite, inducing far stronger opioid effects and no serotonergic effects.

OT: I'm high on sleep... I'm almost out of speed and could take any, because I need it as a back-up for work tomorrow. Fell asleep at inconvenient moments twice now.
 
After under dosing k-pins for the past few days, 400mg cimetidine prior to 7mg clonazepam sub'd has me feeling gaaaa-reat + intrarectal/plugged 2mg bupe + Marlboro Reds + cannabis.
 
LearntYoung said:
Tramadol has a higher affinity towards SERT (Serotonin transporter) and NET (Norepinephrine transporter) than it has towards the opioid receptors, but a large part of it is metabolized into O-Desmethyltramadol, which has no (noticable) effect on Serotonin (I don't know about Norepinephrine) and way stronger opioid affinities. In layman's terms: Tramadol is a weak opioid with SSRI properties, which's effects are mostly felt when skipping the first-pass. O-Desmethyltramadol is the major metabolite, inducing far stronger opioid effects and no serotonergic effects.

OT: I'm high on sleep... I'm almost out of speed and could take any, because I need it as a back-up for work tomorrow. Fell asleep at inconvenient moments twice now.
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You mean the SNRI properties are mostly felt when skipping first-pass? Or do you mean that the opioid effects are felt more when skipping first-pass? I would think skipping first-pass would allow less of the tramadol to be converted into O-desmethyltramadol, so less opioid effects and more SNRI effects. Or am I misunderstanding that?
^If this is correct, then that's what I meant by my post. Seeing as most people are looking mainly for opioid effects when taking tramadol, that's what I meant by being 'less effective when plugged'. The SNRI effects are usually not very desirable.

OT: Another ~100mg O-desmethyltramadol on top of the ~130mg I took earlier. Also dosed 150mg of tilidine on top of the O-desmethyltramadol. Feeling very opiated. Very nice! :D
 
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You're correct in thinking that by skipping first-pass metabolism you allow less tramadol to be metabolized into O-DT thus increasing serotonergic/NE properties and decreasing the opioid ones. O-DT has me quite curious since it indeed seems to lack SERT affinity. Thinking about trying it out.

OT: afterglow of phenibut and codeine. Fairly sober but content. Going to go bed. Good night BL.
 
Pill2Chill said:
You mean the SNRI properties are mostly felt when skipping first-pass? Or do you mean that the opioid effects are felt more when skipping first-pass? I would think skipping first-pass would allow less of the tramadol to be converted into O-desmethyltramadol, so less opioid effects and more SNRI effects. Or am I misunderstanding that?
^If this is correct, then that's what I meant by my post. Seeing as most people are looking mainly for opioid effects when taking tramadol, that's what I meant by being 'less effective when plugged'. The SNRI effects are usually not very desirable.

OT: Another ~100mg O-desmethyltramadol on top of the ~130mg I took earlier. Also dosed 150mg of tilidine on top of the O-desmethyltramadol. Feeling very opiated. Very nice! :D
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I meant SSRI, since I couldn't find the NET affinity for oDMT that fast ;) Could be SNRI.
I find the way you put it to words extremely confusing, honestly, but what I mean is:
With first pass: Most tramadol is converted to oDMT before becoming active. Thus you get a more classical opioid effect.
Without first pass: The effect of Tramadol is the main effect, which is greatly influenced by Serotonin and Norepinephrine reuptake inhibition.
 
^That's pretty much exactly what I meant. :p

And yeah, AFAIK tramadol has SNRI properties, so both SERT and NET affinity. Also, I think O-DT barely has any SERT affinity, I'm not sure about its NET affinity either.

OT: Still feeling very, very opiated. Mmm, nice!
Time to watch a movie/series and drift away in a nod/semi-sleep. GN BL!

/E: Aaand, I've just entered nod-town. Mmm, the feels. <3
 
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My bad, I just woke up: Yes, Tramadol certainly has SNRI properties, what I meant to say what that I don't know if the N part changes when metabolized.
 
Feelin' that sub'd 7mg k-pins quite prominently + just procured more potent cannabis, smoking copious amounts tonight + Guinness Draught tallboy-ish can + may plug more buprenorphine.
 
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Havent had more than 5mg valium in last 48h, small victories...

Currently drinking and waiting on the right time to smoke pot.
 
High as fuck, drinking beer, and watching basketball. I haven't smoked in like 4 months so this is great
 
Every time I see this thread (I mean like 99%) l want to say "not high enough!!!!"

I'm getting tipsy & blazing, wondering whether or not to benny it up. Mmm.
 
Plugged 1mg bupe+6.25mg promethazine
Sub'd 1mg bupe+prior to subL bupe 6.25mg promethazine
Lots o' cannabis
Either 0.5 or 1mg more of clonazepam subL
More beer
Cigarettes
 
Nodding soo hard. Been a long time since I nodded this hard. The only reason I'm able to write in coherent English right now is because I'm outside in the cold smoking a cig atm. :D
 
Pill2Chill said:
^That's pretty much exactly what I meant. :p

And yeah, AFAIK tramadol has SNRI properties, so both SERT and NET affinity. Also, I think O-DT barely has any SERT affinity, I'm not sure about its NET affinity either.

OT: Still feeling very, very opiated. Mmm, nice!
Time to watch a movie/series and drift away in a nod/semi-sleep. GN BL!

/E: Aaand, I've just entered nod-town. Mmm, the feels. <3
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NET/SERT affinities are less of a concern to me than any Kappa/Delta action alongside my Mu-derived pleasure - is there any of the dysphoria such action leads to?

<3
 
160 mg oxycodone
4 mgs loprazolam (hefty dose)
40 mgs propanalol
Feels v good
Peace connecticut!
 
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