Not very high
Woke up at 10am, took 150mg Bupropion XL and 1.2g Phenibut then crawled back in bed and slept until 1130am. Woke up with both of them kicking in so exactly as planned.
Took a 150mg Bupropion SR at Noon along with 300mg of Gabapentin.
Currently drinking a Zero Sugar Monster Ultra Paradise 150mg Caffeine along with Taurine, and L-Carnitine (can does not list those amounts)
Will take another 1200mg of Gabapentin total throughout the day. Was considering another 150mg of Bupropion but will probably skip it as I have to wake up early tomorrow.
Will also take 50-100mg of Hydroxyzine later on when I go on my walk to find a bench to sit down and read. Will take 50mg Spironolactone omw home
2mg Prazosin after my shower about an hour or so before bed.
7.5mg Mirtazapine when I crawl in bed. Trying to slowly taper off so that I can trip when my roommate leaves for his business trip but I've become so dependent on Mirtazapine for sleep that it's become difficult to stop.
Hey dude from what I’ve read from you before you seem to know what’s what, but I’m always curious with the Bupropion.
My understanding of it is that’s it’s a hassle for mixing, and sometimes can be unpleasant although some find great utility in it, and I was previously considering it before realising they don’t offer it in my country..
I’m quite sensitive but I imagine I’d struggle with just caffeine and bupropion lol, I couldn’t imagine with the cannabinoids etc
a cup of tea made my heart palpitate on my Methylphenidate so I only combine it with Nicotine which is probably still silly.
Bupropion is a hassle for mixing. Difficult to mix DXM with. Have to take precise amounts and take extremely low doses of DXM if not trying to get any recreational benefit. I am curious about Auvelity (antidepressant thats Bupropion/DXM combined). I actually had the same idea for that antidepressant about 10 years back but I don't work in big pharma so no big paycheck for me. Bupropion apparently increases the level of atomoxetine (strattera) 5.1 fold and reduces it's main metabolite by 1.5 fold, which is interesting. My doctor recommended that to me as a possible treatment for my ADHD. I didn't realize it'd increase the levels by that much. I think some doctors underestimate or don't even realize that bupropion is a CYP2D6 enzyme inhibitor.
Honestly, bupropion isn't a huge pain with combinations as long as you make sure that it's safe. I think combos that may increase the risk for seizures are more of a pain in combos resulting from it's liver enzyme inhibition. Though I did recently try 3,4-MD-PCP and blacked out quicker than I think I usually would have. I had just started bupropion treatment not long before that experience so I'm wondering if I just took more than I realized, or if 3,4-MD-PCP is partially metabolized by that enzyme resulting in higher blood concentrations. Apparently taking MDMA with Bupropion increases exposure to both drugs by 30%. I'm not sure how these things work so maybe 3,4-MD-PCP might be metabolized through similar pathways due to the similarity in chemical structure? I don't know enough about pharmacology and pharmocokinetics to know for certain. I've held off on taking certain things with wellbutrin out of fear of seizures more than I have out of concern for its enzyme inhibition. For example, I won't take kratom while on bupropion considering they both lower the seizure threshold. Won't combine tramadol or cocaine with bupropion for similar reasons, and definitely would not take bupropion while in benzo or gabapentoid withdrawal.
From now on I'm going to stop taking my bupropion for a day or 2 before indulging in any RC's, just to play it safe. I doubt most RC psychedelics wouldn't be an issue.
For me bupropion has been a godsend considering the fact that untreated ADHD has been a huge contributor to my ongoing long-term battle with depression. The main issue that I run into is that I have to be extra careful with caffeine. Just a pinch too much and suddenly my anxiety skyrockets. It's a delicate balance considering my caffeine addiction. My doctor suggested going up to 450mg of bupropion but I declined due to the fact that in the past it has made me extremely anxious, especially with caffeine. I'm considering trying it because I seem to start to lose focus around evening. Maybe I'll see if he'll prescribe me a 75mg IR bupropion on top of my 300mg SR per day. I think I might be able to handle it a bit better now that my anxiety is being treated with gabapentin and hydroxyzine.
Have to be EXTREMELY careful with cannabis. Even 2-3mg of THC orally I have been finding more intense than desired. Usually I can handle 5mg THC or so pretty well, but since staarting bupropion it causes me anxiety very eaasily. I am sensitive to cannabis and it's anxiety producing effects though.
Pretty high. I had 150mg's of oral morphine and 10 300mg gabapentin
That sounds like a fantastic way to spend a day. Have been feeling nostalgic about my morphine days. Would slowly bite away at 100mg extended release morphine everyday and just sit and read books and tend to my cannabis plants during the day and binge watch movies at night. Would take 1-3 of those 100mg pills a day depending on how many we had laying around. Sure was a rude awakening when we ran out though
