Iโm quite sensitive but I imagine Iโd struggle with just caffeine and bupropion lol, I couldnโt imagine with the cannabinoids etc
Bupropion is an absolute godsend of a compound for me, I'll be exploring a handful of analogs of it hopefully within a year or two. I should preface this by saying that I have a super complicated medical history that can be summarized as ulcerative colitis/sometimes considered crohn's disease but sometimes just U.C, a ton of brain damage from surgical fuck-ups, 17 surgeries, a small fraction of my small intestine left as patchwork and no large intestine at all, 12-15 concussions to the point of being told I was edging up on "pugilistic dementia" at the age of 18, before ever using hallucinogens too I caught a schizophrenia diagnosis that has since been wiped from my record, because for some reason, cannabis makes me normal for 3-4 days, so if I smoke every few days or take some tincture I'm fine. Years of serotonergic psychedelic exposure got my brain to scan with zero lesions for the first time ever too. I just want to preface with this because I'm not a good source on dosage, I likely poorly absorb a large variety of things, and I have unironically never felt anxious in my entire life, likely as a result of the brain damage (I cannot recall anything from before it).
SuperPsych already said the majority of things that I would've said, the main thing is to be well aware if anything you're using is metabolized by CYP2D6, for example DXM or tramadol. Sometimes people do this on purpose, I'm a fan of "fauxvelity" I've been calling it, when DXM and bupropion is mixed. It's a much more hardcore dissociative experience with less psychedelia imo, closer to 3-HO-PCP or DCK rather than 3-MeO-PCP or 2F-DCK, if that makes sense. Keep in mind that Bupropion is two carbons away from being 3-CMC, 3-Chloromethcathinone, an entactogenic stimulant. When I first came upon Bupropion, my initial remarks were written down, referring to it as "slow motion Ritalin", in a similar way to my descriptions of mescaline as "slow motion 2C-B" and 2C-B as "fast-forward mescaline". It noticeably acts as a stimulant, with residual stimulation easily lasting over a day when taken in very large amounts. I've never gone about 600mg in a day, but I usually weigh about 100kg, and this drug absolutely scales by bodyweight.
As far as routes of administration go, insufflated Bupropion metabolizes differently by skipping first-pass metabolism, and it acts much more as an NDRI whereas oral administration is moreso just an NRI. Oral Bupropion reminds me of ephedrine, yohimbine, and methylphenidate in character, like if amphetamine was trying to act like all of those. When insufflated, it's tough to tell that it's not methylphenidate or some peculiar RC phenidate. Mixed with 4F-MPH, MPH, amphetamine, methamphetamine, MDMA, MDA, and NEP it has been fantastic imo, but I also had a serious Bupropion tolerance at that time and I've always been notoriously hardy towards stimulants, as with most drug classes. Bupropion withdrawals are fucking terrible but can be eased with ephedra sinica tea (mormon tea), the withdrawals felt identical to taking 10mg of Prazosin for the first time. By saying that, I mean it had me passing out randomly throughout my day like a Victorian woman catching 'the vapors'.
For me personally, Bupropion is dreamy as fuck. I've found my sweet spot is using 75-225mg up to 3 days a week, sometimes all in a row, sometimes broken up, but any more and the tolerance becomes annoying, and daily administration is just begging for habituation. Avoid that, and use Bupropion acutely as a stimulant more noticeable than caffeine, modafinil or fladrafinil, but less noticeable than methylphenidate, amphetamine, methamphetamine, or NEP.
I'm not sure how these things work so maybe 3,4-MD-PCP might be metabolized through similar pathways due to the similarity in chemical structure? I don't know enough about pharmacology and pharmocokinetics to know for certain.
From what I understand of arylcyclohexylamine structure activity relationships, it shouldn't relate to why MDA or MDMA may be enhanced by Bupropion for some, but it's tough to tell if one of the metabolites of 3,4-MD-PCP would downstream be metabolized by CYP2D6, therefore causing unexpected effects. Once more research occurs in the future, I'm sure we'll be able to tell.
For me bupropion has been a godsend considering the fact that untreated ADHD has been a huge contributor to my ongoing long-term battle with depression. The main issue that I run into is that I have to be extra careful with caffeine. Just a pinch too much and suddenly my anxiety skyrockets. It's a delicate balance considering my caffeine addiction.
I was savagely addicted to caffeine (600-1,000mg daily) for something like 6 years straight, 3 of them taking 300mg of Bupropion IR, often intranasally, and I was able to function as a result of these things alongside the antipsychotic effects I gained from cannabis. It was a mix that would maybe not help everybody, but for me personally dealing with chronic fatigue from malabsorption, it was pivotal because I had to have enough energy and focus to code for 8-10 hours a day, daily. It also made things like skateboarding and working out easier to do, free from exhaustion and with an easier time actually getting up to do things. I'm about 10 minutes from taking some to aggressively clean my bedroom.
My doctor suggested going up to 450mg of bupropion but I declined due to the fact that in the past it has made me extremely anxious, especially with caffeine. I'm considering trying it because I seem to start to lose focus around evening. Maybe I'll see if he'll prescribe me a 75mg IR bupropion on top of my 300mg SR per day. I think I might be able to handle it a bit better now that my anxiety is being treated with gabapentin and hydroxyzine.
My docs don't want me above 300 right now so I'm going to push for methylphenidate on top of it, but I'd love to do both 450mg of Bupropion a day on top of some methylphenidate, as anything that I don't use just gets added to the antidepressant stockpile. I'm prescribed gabapentin right now, but hydroxyzine is something I'm also going to try to get added on, all of these seem like they're quite liberally prescribed right now and they seem really slept on in my opinion.
Have to be EXTREMELY careful with cannabis. Even 2-3mg of THC orally I have been finding more intense than desired. Usually I can handle 5mg THC or so pretty well, but since staarting bupropion it causes me anxiety very eaasily. I am sensitive to cannabis and it's anxiety producing effects though.
I've known this to occur in maybe 2/3 Bupropion users, it didn't hit me that way but I've been consuming cannabis since I was 13, so I think I may have just already been used to it. Bupropion is key in producing people I know who love LSD, psilocybin, etc., but not cannabis or MDMA.
Thank you
@SuperPsych for articulating virtually every point I would've brought up to this guy, I just tried to add some observations I've made over many years of using a shit ton of Bupropion, and being around a ton of other people who do too, via both oral and intranasal RoAs.
~~~~~~~~~~~~~ Back on topic, not hyperfixating on Bupropion anymore because it's way too easy for me to waste hours talking about it, hahaha.
Could you go into a little bit more detail as why you consider Hydroxyzine to be "like Soma lite"? I usually take 50mg-100mg but don't see many similarities between the 2. I do like Hydroxyzine. It's got great utility considering it's just an antihistamine. I'm wondering if I'm missing something that occurs at higher doses.
Yeah, I've used an insane amount of Soma from a variety of sources and producers, and it feels like Soma from 175-225mg, which is as high as I've pushed it. Hydroxyzine is less myorelaxant but more cognitively relaxing in my opinion, but I've yet to notice any other major differences between ~225mg of hydroxyzine to ~750mg of carisoprodol. I doubt I could distinguish them in a blind study, outside of hydroxyzine lasting maybe 1.5-2 hours longer, and coming on in a more gentle way. Soma kind of hits like a bus.
I am very sorry to hear about the loss of your cat. It's always so difficult trying to process the loss of a special relationship like that. I'm glad to hear that your eyeballed 2C-B and 20mg 4-ACO-DMT trip went well. I think that waiting 10 days (at least) is a wonderful idea. I personally and in the camp that adding stimulants to a psychedelic adds nothing beneficial to the trip. Maybe I'm wrong but in my experience they don't. The only stim + psychedelic combo that I will support is Mescaline and Amphetamines and that's only because of Allen Ginsberg lol. I did once have a good time dropping LSD while high af on meth but I think that only turned out okay because we also dropped 5-MAPB. Think we added 2C-B and maybe some other later on. Dropped a bit of oral meth and a lowish dose of 2CB at an Infected Mushroom show and really regretted it. I also haven't met a depressant that I feel adds much to a psychedelic experience, though Heroin + LSD I have heard is fantastic and I want to try before my time comes. I think downers can be good during a psychedelic comedown, especially after longer sessions.
Meth and acid sure are fun together, I've used meth maybe 50-ish times total in my life, for sure less than 100, always in the form of counterfeit Adderall. First time I was 15 and just thought "damn, that Adderall lasted a REALLY long time". I've mixed LSD, 2C-B, allylescaline, and miprocin with NEP, amphetamine, methamphetamine, and 4F-MPH personally, each possible cross of those two groups, and I fucking adore it personally. Soma, floribut, tapentadol, 7-OH-mitragynine, mitragynine, tianeptine, bromazolam, etizolam, alprazolam, diazepam, bromonordiazepam, phenazolam, flualprazolam, promethazine and tizanidine (intranasal strictly) are all great in mixed with psychedelics, but the more GABA heavy you go, the more you need to increase the psychedelic dose to have equivalent effects given GABA doesn't kill a trip but it can mute certain aspects of it. If 3 tabs of acid is the desired experience along a milligram of flualp, you'll need 4-6 tabs of acid, depending on the situation. I love mixes like these as being sort of "vibe shifted", acid and meth is great for cleaning, acid and soma is great for sex, acid and etizolam is great for meditating, all just different tools for different situations for my personal neurochemistry. 2C-B and allylescaline are gentle mixes, miprocin can be a little much if the come-up overlaps with others but it's still nice for me, I just wish mip lasted longer because taking it with meth is amazing, but once the mip wears off it gets pretty boring.
DXM I've only mixed with psychedelics once and that was with LSD. Was pretty cool, though I doubt that I'll try mixing the 2 again. Honestly, I would recommend a high dose of DXM by itself if you have the time and don't take any medicines that interact. I have had some of my most profound drug induced experiences on high doses of DXM. Not to mention the greatest music enhancement and music euphoria that I have experienced. DXM + a cigarette at the peak followed by a little bit of weed an hour or so into the peak is earth shattering stuff. Some of the most beautiful feelings of serenity and euphoria that I've ever experienced.
As for combos that stick out? I haven't tried this one but Ii intend to, and that Mescaline + Allylescaline. I dont yet have experience with 4-HO-DET to see how it plays with other tryptamines, but 4-HO-MET and 4-HO-MIPT have always treated me well when mixed. Add a bit of 4-ACO-DMT as the peak from the other 2 start to fade if you're wanting something more serious by that time. I'm sure that 4-HO-DET would also mix well and hell, probably DPT too. 4-Substituted tryptamines never seem to produce immediate tolerance for me. I can ride out the peak from 4-HO-MIPT and towards the tail end add 5mg of 4-ACO-DMT and it its clearly percetible and changes the character of the trip.
I havent triied this yet either but I'm certain that Allylescalin with 2C-B added as the Allyl kicks in would be a beautiful trip. Never considered that but it's goin onto my "to-do" list of combos
DXM is definitely one hell of a drug, it was technically the first time I tripped ~15 years old, I was mostly just shocked and had no idea what it was useful for but found it to be neat, like a peculiar variant of a THC edible. Your suggestion of metocin and miprocin together is interesting, I should try every crossed combination of the four 4-subs I have on hand, 4-HO-MET, 4-HO-MiPT, 4-HO-DET and 4-AcO-DMT. Vaporized DPT while on DOB and 4-AcO-DMT a few weeks ago was fascinating, I'd been smoking some MDMB-4en-PINACA and earlier in the day took Bupropion and DXM, not a combination I imagine is the safest but god was there a lot going on cognitively. It was on par with a high dose of ayahuasca/acid/dabs all together, in a very interesting way that could be therapeutically valuable, but could also easily send somebody to an asylum too imo. Allylescaline and 2C-B are a beautiful combination, allylescaline alongside 3-HO-PCP (orally) , LSD (eyedrops) and 2C-B produced one of my favorite trips of the last many years. It's shocking how effective allylescaline is intranasally and vaporized, it's wild that more people don't use those RoAs for it imo. Allylescaline alongside DOB was neat, it had seemingly a mild synergy with tapentadol, and it seems to cut through benzos very effectively like 2C-B or DOM, as opposed to the psychedelics more easily overshadowed like tryptamines, lysergamides, DOB and DOC.
I'm going to spend more time really getting to know these 4-subs, collectively I've got about an eighth ounce between all four I mentioned, not including mushrooms or fungi cultivation supplies, so I'm excited to see how it goes.
My friend has done alot of pcp and she loves it. She has never seen anyone have a bad reaction to it either. But if you where able to be ambulatory on that stuff i could see problems arising maybe. I think id be ok i dont react badly to any drug.
I've never seen anyone react poorly to PCP either, and I've administered it to a good handful of people, 3-MeO-PCP and 3-HO-PCP specifically. One person though consumed amphetamine that we did not know was tainted with 3-HO-PCP, and that was a rough drive for him but he made it just fine.
10mg cyclobenzeprine. 5mg buspar.
How would you characterize either of these relative to other drugs you've used?
Yeah working out on ketamine is a disaster waiting to happen. I get what you're saying, but regardless of isomer, Ketamine sending you into a hole is dose dependent. On lower doses I can enjoy some movement. Though once I try going outside and walking then it ceases to be enjoyable. I love running around the house and doing chores and dancing on a low dose of ketamine, but for the most part ketamine just makes me want to sit on my ass and do massive lines to experience hole after hole, or get right to the edge of a hole and watch some anime.
Low doses of ketamine, only if you have a moderate-to-high ketamine tolerance, can be relaxing in a way that enhances focus and stimulation. As goofy as it sounds, I was using ketamine daily for 10 months due to some serious health issues, ~125mg daily on average, cleaned 29 grams of mixed arylcyclohexylamines over that time (1g DCK, 14g ketamine, 1g 2-FDCK, 9g 2F-O-PCE aka "CanKet", 1g 3-MeO-PCP, 2g 3-HO-PCP, 1g 3-HO-PCE) and I found that any and every one of them had this "tolerance-dependent nootropic" effect, I actually wrote a lot of the best code and music of my life under the influence of things like 2F-DCK, 3-HO-PCE, 3-MeO-PCP, etc. as a result of this weird phenomenon that you really only come upon if you're abusing the absolute fucking life out of dissociatives.