F.U.B.A.R.
Bluelight Crew
Many antidepressants inhibit the reuptake of serotonin leading to the brain being constantly flooded with serotonin. Psychedelics and similar drugs like MDMA work by flooding the brain with serotonin, but as the brain is already flooded the effect is diminished and could actually be dangerous due to increased risk of serotonin syndrome. Or summat like that anyway...