"The one thing humans need to understand is their insignificance"
And our egos prevent us from doing so. They are in direct opposition to the very idea. Our egos even invented a supreme being, like us but supreme, let's call HIM God, to create evidence that it's all about US. Animals don't get into heaven. The world is ours. Even the dead world, coz were not dead, just in heaven. Without the cockroaches.
Of course it's bollocks. Were created with a consciousness and imagination that needs to understand and explain everything but is prevented from doing so by having the handicap of seeing ourselves at the centre. The meaning we find has to be ours. For us. That's how you got God. (That and the need to shit on the previously worshipped female side of things, but that's another story).
Without our egos we are at one with that from which we came. Our egos make us seperate, alone. With our egos we are always in conflict with that from which we came. To the ironical and paradoxical extent of having the ability and will to destroy everything we want to rule over and may one day do just that.