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Gabapentinoids Gabapentin Megathread

Yeah, and it's not to expensive. Not much more than a clonazepam script from my experience.

I personally like gabapentin alot. I don't get any recreational effects from it any more, and barely did when I first began using it semi-regularly. Combined with alcohol, it becomes a different monster (in a good way). I could take a gram or so, go to the bar and over a few hours only drink 2-3 drink max. That quantity of alcohol would get me nicely drunk, but with out a lot of the negative alcohol side-effects. There was a lot less potential for a body load, notably less of your typical alcohol induced nausea. There is no alcohol hangover the following morning. It has a clearer head space for a equivalent level of intoxication of alcohol alone, which allows for better decision making while your levels of inhibition are very high. Seen with taking gabapentin alone as well as in combo, it's anxiolytic benefits for social anxiety are through the roof, making it a perfect companion for hitting up women comfortably and confidently.

Combined with amphetamine salts (adderal formulation), gabapentin can make the peripheral body load a lot lower, but seems to also require a higher dose for desired euphoric effects. It also helps stabilize your mood during the peak but also during the come down. So it has it's advantages and disadvantages with amphetamine imo.

With opioids in combo, I haven't had any real notable experiences, but also no negative experiences. It can make the body high a little softer, and add a slight sedation, but no real euphoria increase with it.

Therapeutically it is a excellent drug to treat social anxiety. Gabapentin has very little noticeable side-effects (I've never experienced ANY), and a small physical dependence making it a lot better option than benzodiazepines for social anxiety. Higher daily doses in the gram range can produce a 24-36 hour withdrawal 24 hours after the last dose. This withdrawal can be pretty annoying for that day small window, but knowing it will end as fast as it came makes it pretty easy to get through. If tapered, this shouldn't be a problem at all. Not only is it better for long term use than benzos, it's social anxiolytic effects imo are more effective than diazepam, alprazolam, clonazepam, and lorazepam. Its not as great for general anxiety, but it's social anxiety relief doesn't feel artificial like benzos anxiolytic's effects can sometimes feel, making it a good learning tool for working through it.

It also has pretty great mood stabilization effects. My mood can change fast while on it, though not as steeply, and the recovery period is relatively quick compared to my normal recovery period. It doesn't force you into feeling things in any certain fashion, nor prevent natural mood changes, so it works well allowing you to learn how to control your mood swings while still getting some relief (also with non noticeable side-effects).

It's ability to help get through opioid detoxification is also something that should be noted ime.
 
Gabapentin takes the edge off of most stimulants and puts me to sleep rather nicely, but it makes me foggy headed all the next day, and I almost ALWAYS wake up too early after a night of being put to bed by good old mexican gabapentina.

I'm curious to know if the bioavailability is increased by plugging it? Just wondering.
 
Gabapentin

so, i can't see my psychiatrist until late next month to get on my normal med regime. there is an emergency psychiatric room i can go to where i was offered gabapentin and vistaril once, but never got the script because i was so angry they wouldn't give me what i need. (you have to sit there for HOURS with loons. GREAT for anxiety - just to get treated like a junkie for needing klononpin).

anyway, i am wondering if i should go back. i know vistaril doesn't really do shit for me, but i don't know much about this gabapentin. i just asked a friend who says it works "fairly rapidly", but i assumed it was like an ssri. where you take it over a period of time and just have to *guess* if there is a difference.

experiences please? i understand not everyone who has used it has an anxiety disorder, so if you have one that would be more helpful, but all experiences are welcome.

do you feel this working? does it really kick in fast? is it stronger than vistaril?

i really want to get as much info as possible before i go back to that hellhole to get a prescription.
 
If you use the search engine, you'll find a gabapentin mega thread that has a lot of helpful information on it.

Gabapentin is not like an SSRI. I believe it is sometimes prescribed as a mood stabilizer, but more often for neurological pain, and for it's anti-seizure capabilities. Like benzodiazepine's (Xanax, clonazepam etc..), Gabapentin works on the same receptors (GABA), though it's kind of unclear as to what it actual does. For anxiety, gabapentin can definately be used. It's not as good as Xanax, clonazepam or diazepam IMO, but it's great for when you don't have access to those drugs. It kicks in after about 20 minutes when taken orally, and last a pretty long time. The one thing about it that sucks, is that once you reach a certain dosage (somewhere around 2 grams I believe), taking more of it will actually decrease how much actually gets absorbed. So the best way to use it for anxiety, I found, is to take it as needed, and if you must take it every day, than keep your dosage low, like 600mg/day.

Hope that helps some.
 
thanks, i'll search that now.

i went ahead and got the prescription. besides the four and a half hour wait, it was tolerable up until the last part, when the woman who gave me my discharge papers was a complete and utter cunt. i'm usually a pretty reasonable person, but i called her a fucking bitch as i left. i have zero tolerance for people who work in the mental health field and use it to take out their own issues by treating the patients like shit. it is SO hard to find a good psychiatrist. fucking hell, i hate the mental health industry. while i was waiting this idiot came in who was trying to get oxy's there! that's part of why people like me who actually need controlled substances can't get them.
 
Gabapentin does not work on GABA. It was developed as a GABA analogue but it doesn't seem to work on the same receptors (likewise with pregabalin---it's a total coincidence they actually ended up being among the greatest discoveries by Pharma in recent years)! It's exact mechanism of action is unclear.

http://en.wikipedia.org/wiki/Gabapentin#Pharmacology

For me, it takes two hours for gabapentin to kick in. If I drink coke or a carbonated beverage, it takes one hour.

Gabapentin's bioavailability does decrease with increased dosages, but I believe it's pretty dose dependent meaning that the more you take, the less bioavailable it becomes.

"Bioavailability for the immediate-release tablets decreases as dose increases; bioavailability is approximately 60%, 47%, 34%, 33%, and 27% following 900, 1,200, 2,400, 3,600, and 4,800 mg/day given in 3 divided doses, respectively. Food has ony a slight effect on rate and extent of absorption (14% increase in AUC and C max ). Bioavailability for the ER tablets is approximately 75% (with food) and 42% to 65% (fasting). T max was 7.3 h (with food) and 5 h (fasting)."

http://www.drugs.com/ppa/gabapentin.html
 
Today, after half a year, I did 3600mg of Gabapentin Neurontin brand. Usually, I would buy Lyrica, but for some reason, I choose Neurontin this time.
Well, In December 2011 I did 24/7 GBL. It was and is to this date, the best drug I have ever did, even if it harms your body or kills you; I know the risks of taking GBL.

In January 2012 I had a nasty WD of GBL. I felt *very* depressed for almost a week. I still think of buying more, but I couldn't.
The point of this story, is that today, after 5 hours of ingesting the pills, I felt like I was on GBL. Maybe not so euphoric as I was but... the happiness, the mood lift, the music enhanced, the "warm" feeling.. I don't know the pharmaceutical way of Gabapentin... I don't know how it works, even the prospect of Pfizer says they don't know how it works, but I can assure it feels like a low dose of GBL. It is awesome.

I just wanted to share this. Now I will do some Codeine because I have read it enhances opiates.

I would really like to know how GBL/GHB are connected with Gabapentin...
 
Just so you realise...

Neurontin is Gabapentin and Lyrica is Pregabalin... Two completely different drugs.

GBL/GHB is a GABAb agonist gabapentin is a GABA analogue.
 
Just so you realise...

Neurontin is Gabapentin and Lyrica is Pregabalin... Two completely different drugs.

GBL/GHB is a GABAb agonist gabapentin is a GABA analogue.

Of course I know that. I have read all the Wikipedia of Gabapentin, Pregabalin and GHB/GBL. But I'm not the only one who feels large doses of Gabapentin like a low GBL/GHB dose. As I said before, I would like to know why this happens. I can assure you it's not placebo. I wasn't even thinking about GBL when I did Gabapentin, yet I feel the same effects.
 
Of course I know that. I have read all the Wikipedia of Gabapentin, Pregabalin and GHB/GBL. But I'm not the only one who feels large doses of Gabapentin like a low GBL/GHB dose. As I said before, I would like to know why this happens. I can assure you it's not placebo. I wasn't even thinking about GBL when I did Gabapentin, yet I feel the same effects.

This surprises me. I guess I get the body high of GBL, but my mental intoxication off of gabapentin feels more like THC.
 
gababpentin with benzos and opies == sexxx...no maybe not secks, but its fucking mind blowing
 
People have found pregabalin and gapapentin to be highly promiscuous. They are predicted to bind to a ton of human proteins. So the way they exert their activity is through sophisticated network based multitargeting IMO (for now). They're targeting whole systems that regulate your body and this could include the GABA-based systems even though we know they don't bind GABA_A itself directly in vitro. Given the multtargeting nature and natural sequence variability of humans, this is why probably why you see the effect you do and others see a different effect. It is not wholly surprising at all. But I'd argue they are not exerting their activity through GABA directly but rather through other mechanisms. From Wikipedia:

"Gabapentin was initially synthesized to mimic the chemical structure of the neurotransmitter gamma-aminobutyric acid (GABA), but is not believed to act on the same brain receptors. The mechanism of action that leads to its rapid analgesic effect is simply unknown. Some of its activity may involve interaction with voltage-gated calcium channels. Gabapentin binds to the α2δ subunit (1 and 2) and has been found to reduce calcium currents after chronic but not acute application via an effect on trafficking[40] of voltage-dependent calcium channels in the central nervous system.[41] Another possible mechanism of action, reported by Ben Barres and colleagues in Cell in 2009, is that gabapentin halts the formation of new synapses.[42]"

(Hmm, interesting; I didn't know Ben Barres was looking into gabapentin.)

Of course I know that. I have read all the Wikipedia of Gabapentin, Pregabalin and GHB/GBL. But I'm not the only one who feels large doses of Gabapentin like a low GBL/GHB dose. As I said before, I would like to know why this happens. I can assure you it's not placebo. I wasn't even thinking about GBL when I did Gabapentin, yet I feel the same effects.
 
Gabapentin is great. So great and clean. I feel it just enhances and supplements the life around us, it does not interfere with it. It is probably my favorite compound.

Such a beautiful drug at high doses staggered. I achieve a brilliant hallucination in the mirror where I saw my soul tiling around me body. Then I rolled around on my floor and loved it. I felt so free. =D

I took 2.7g in 300mg staggered for about 8 hours. I did then pass out too, which was unexpected, but woke up and was still feeling it. I love how it binds to entire systems of proteins and thus affects everyone differently. What a great drug. I know there are some lovers on Bluelight of it too. 8o
 
Neurontin?

I might be going to be prescribed this, anybody have any experience with this?
 
It is a very good medication. Not much abuse potential. It has a calming effect, but not quite the same as a benzo does.

What are you being prescribed this for, and what is the dosage? Also what other daily medications do you take? I can answer better if I have more info.

It was originally an anti seizure med, but has been shown less effective in that capacity than the clinical trials led us to believe.
 
neuropathic pain is the main purpose, I don't take anything else, I don't know the dosage yet I am just getting insight I see the neurology specialist on monday.
 
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