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Ethylphenidate Discussion Thread

^ Esotericism is a cool guy, can't wait to read through these studies on ethylphenidate. Hopefully I find time tomorrow evening to get some reading done. :)
 
Once I've read through I might post up pertinent quotes, do remember though that these papers are the intellectual property of the authors and unless they have already been publicly distributed for free we can't just post the whole lot up. :)
 
thanks Esotericism and Mr B for all the great information and discussions, i have learnt greatly already and feel we will have good HR info in time for the lift off
 
^ I can't be bothered to look up IUPAC priorities for naming enantiomers, but yes I believe that is the name for the dextrorotary isomer of ethylphenidate.
 
^It's the levorotary isomer, check the diagrams in "Differential Pharmacokinetics and Pharmacodynamics of Methylphenidate Enantiomers Does Chirality Matter?"
 
^ Cheers brother, you are right indeed. :)

I'm only partway through reading the papers you sent due to a hellish week at work. I knew that + and - don't always correlate to dextro and levo, but wasn't sure on the priorities of the groups attached at the chiral carbon. :)

ETA: Also this is a threo compound it looks like so they wouldn't be enantiomers anyway... damn I need more coffee.
 
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AyahuascaSeeker13 said:
^ LOL WTF. I don't remember writing that. SO SORRY. To much MXE and Etiolaam at night lately. WAY to much I think. Tonight a little less, switched RCs to my small ass sample of Ethylphenidate, which is almost gone but working a fucking charm!!!!

SORRY, I feel like a cunt now!:(
Click to expand...


hahaha that's why I hate ket, mxe and anything to do with the above ;)

Hey, was your sample crystally/shiney?
 
In case anyone was interested, it turns out that ingestion of ethanol and methylphenidate produces the pharmacologically inactive l-ethylphenidate. Ingestion of ethanol does, however, increase maximum plasma concentrations of methylphenidate. Here is the conclusion from the relevant study:

Conclusion
Ethanol produced significant increases in both the AUC and
Cmax of d-MPH. Increases in both the rate and Cmax of MPH
have correlated with MPH abuse liability.20 Accordingly, in
view of this MPH–ethanol drug interaction, alternatives to
MPH pharmacotherapy may warrant consideration in the
rational treatment of adult ADHD with comorbid alcohol use
disorder and/or substance use disorder. In such cases,
other approved treatment options, such as amphetamine or
atomoxetine, offer alternatives to MPH therapy although not
being associated with reported ethanol pharmacokinetic
interactions in humans.
The metabolite ethylphenidate forms enantioselectively,
yielding primarily the inactive14 l-isomer. Thus, this metabolite
is unlikely to directly contribute to the pharmacodynamics
of the MPH–ethanol interaction. The novel MPHpoor
metabolizer identified in this study may represent a
distinct polymorph, or only a rare metabolic defect. Female
subjects reported significantly greater subjective effects to
MPH across treatments. This drug sensitivity could constitute
a sex-based differential vulnerability to MPH abuse.
Click to expand...

Influence of Ethanol and Gender on
Methylphenidate Pharmacokinetics and
Pharmacodynamics
KS Patrick1, AB Straughn2, RR Minhinnett1, SD Yeatts3, AE Herrin3, CL DeVane4, R Malcolm4,
GC Janis5 and JS Markowitz1,4
 
some1s getting hell excited wiv it, buying bulk
 
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I'm interested in hearing people's first hand experience with the different ROAs of ethylphenidate. What can be done with it? Or I should probably ask what can't be done with it? How do effects vary with different ROAs? Is it close enough to methylphenidate to treat literature on one as the same for the other?

I'm also interested to know about how it can be best utilised as a clarity/energy booster for someone who has a job which involves large amounts of reading and face to face time with clients. Would an oral dose of 20mg be a good first try? This would be for someone who has ZERO experience with stimulant substances (aside from coffee) and an increasing problem with attention deficiency...

Thanks
 
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