[FONT=Arial, sans-serif]Hiall.
I've been using the forum as an spectator,but now I feel my duty to help and avoid peoples bad trips oraccidents.
I have a PhD in Organic Synthesis and Pharmacology,so I have knowledge about a lot of stuff here. I'm also an user. I'mfrom certain country in America, and pretty much been trough all kindof stuff (Not Heroin or Crack). So I know some stuff quite well.
Myfirst contribution will be about one of my fav's here in theUK...Ethylphenidate.
As you all know a lot of this, I willskip to the details that might be wrong, or create somediscussion.
The LD50 of this is slightly higher than the oneof his parent compound Methylphenidate (195 mg/kg in mice, which isroughly 135 mg/kg in humansafter convertion), so pretty much an average John Doe need to take 10grams in a 4 hours (HL) to die (OD death, but previous reasonsexist). Below that you have the ED50 (0.085 mg/kg in mice, so it isabout 0.06 mg/kg in humans) of an average John Doe is 4.5 mgapprox.
Half life is 4 to 4:30 hours, main excretion route isurine, followed by feces. All the metabolism to the main molecule(Ritalinic Acid) is made in the Liver (so please, no IMAO's or heavymedications if trying this). The metabolic constant follow the firstorder rate, which means that the metabolism of the liver eliminateshalf of the quantity every 4 hours period. (If you take 100mgs, youwill have 50mg in your blood after 4 hours, this way until you arebelow the 4.5 mg we said before. Take this on mind whenre-dosing.
The ROA's are quite similar; IV is the fastest(right away!)...Try to dosage according previous numbers. IM,snorted, plugged and sub-lingual are the second most efficient ones(From 10 to 30 seconds), they by-pass the First metabolic route(Stomach-Liver) by delivering compound to the blood by osmoticconcentrations via blood vessels. Oral is the less efficient, havingthe compound in blood in about 5-10 mins in an empty stomach.
Themolecule itself has a pKa (the pH at which half of the drug is in anysalt form and the other half is the free base) is 8.9 in theNitrogen. This means that if you snort the salt (pH 7.2) you migh notsuffer as much as with the free base (9.68) wich will take a protonfrom anywhere in your body and cause a caustic burning.
Allthe -phenidates are metabolized (ester is broken) by theenzyme carboxylesterase CES1A1, which will give you thenon very active metabolite (ritalinic acid), and as an exchangableproton zwitterion, will be treated as a salt and excreted by thekidneys due to osmotic regulation.
So, jumping the scientificstuff, lets talk about what many asks.
My kidneys hurt aftertaking this: Well, is a vasoconstrictor, meaning it willdecrease the lumen of the blood vessels and increase the pressure, soa little bit of blood at high pressure will run trough your kidneys,causing physical damage by the pressure and as you have just littleblood, the temperature will decrease, causing hypothermia-likedamage. Haemodynamic failure and rhadomyolysis (due to the highquantity of proteins from destroyed over excited cells in your blood)are the worst conditions, but necrosis might happen. You can avoidthese symptoms by keeping yourself warm and drinking lots of warmliquids (you need to clean your blood, remember?), 1 liter of warmwater every 2 hours will do.
As it is triple action agonist(affect the transport proteins for reuptake of Dopamine [thestrongest, just like Methylphenidate], Norepinephrine[not as good as Methylphenidate, because of steric impediment due tobulkier ethyl group, about half the binding affinityy] andSerotonin [by binding the 5-HT1A receptor, it stimulates the releaseof Serotonine, but this affinity is quite low, so the Serotoninerelease is neglected]), meanin that you will have plenty of Dopamine,Norepinephrine and a little bit more of Serotonine in yourbloodstream. Also bind sligltly to the opioid σ1 receptor,meaning that will increase the permeation of Calcium and Potassiumions in the cell wall, causin numbness and light anesthesia as it isnot a full agonist. This causes the numbness in your nose/lip aftersnorting.
You all know the reactions of these lovelymolecules. The side effects are caused by neurotransmitter poisoning([Dopamine will cause you psychosis, nausea, pain of destroyedover-excited muscle fibers, and excess of shaking as direct sideeffects, Renal toxicity due to the proteins in urine will be a sideeffect, as well as not being able to sleep], [Norepinephrine willgive you energy, tachycardia, arousal {personal fav}, hypertensionand dehydration due to high Renal filtration as direct effects.Hearth damage due to fatigue, Renal damage due to high pressure,pulmonary damage due to alveolar damage due to pressure and braindamage due to pressure are secondary effects. [Serotonine poisoningis quite unusual, but can be increased intestinal movement and celltoxicity due to inhibition of Adenylate Cyclase {an enzyme thatbasically builds the cells} as direct effect, and as secondary effectyou can wait high blood pressure and kidney damage]) are usuallyreached when passing the TD of 5mg/kg in a 4 hours period. Any belowthere, means you are safe (assuming you have normal MAO levels, keepgood hydration and body temperature.
About the nose afterusing it as ROA, the best way to deal with it is to rinse withisotonic solution before (9 grams of salt in one liter of water, ifyou use only water [hypotonic], you will cause a dry nose as thecells in the membrane will try to absorb water to keep the osmoticequilibrium. If you use too salty [hypertonic] solution, yourmembrane will release water and the Ethylphenidate will be absorbedquicker, but more painfully as well) snorting, wait 5-10 mins toabsorb (by osmotic equilibrium, if you have too much Ethylphenidatein your nose, will not be absorbed as the equilibrium has beenreached) and rinse with isotonic solution or hypotonic if you wish torepeat a line. This apply only to the Ethylphenidate salt.Ethylphenidate base, as organic molecule, can permeate the cellmembrane slowly, but will be quite caustic due to the pH and it willbe 99.9% ionized in the water media (blood).
Well, I believethis were all the questions I had when I started RC. Feel free to askif I can help you with anything!
Cheers and stay safe.[/FONT]