As a fairly new user who has rolled 16 times since 2008 and is in the middle of a 4 month break ... everyone that I know who over used in their day ie: rolling Fri-Sun every single weekend for years on end ...they have damage.
Anxiety and depression that they all need to take meds for. I am talking at least 5 people I know. I only know 1 person that this didn't happen too out of that group and I am married to this Superman

of course none of them rolls like they used to. That's what happens from abuse of this drug.
It is thanks to these people and the people here on Bluelight plus my own constant research that has driven me to stop honeymooning and take breaks.
If it does cause serious damage, I hope to be one of the ones who escapes it by rolling responsibly. No more going 2 days straight with no food or sleep. No more going past normal dosage. Happy rolling everyone. PLUR