since we are only talking about edm, then i would suggest giving this a try for drug of choice on a night out:
Mandy moonrocks are better suited for trance (prog and vocal), house (deep house)
Mephedrone and Blow would be better for those top 40 electro pop they play at shitty but popular clubs
Mephedrone also goes very well with repetitive shit too, but harder and grungier, like hard house , techno, hardstyle
back on to topic, to really vibe with those obnoxious loud sounds of dubstep, that would certainly make someone unfamiliar with the genre cringe and wear ear plugs, you need the proper substances. or a combo.
My favorite two combos for dubstep shows would be, AMP/Adderall + ketamine, or MXE + a couple of beers or low alcohol content beverages.
I have ought to try the AMP + MXE combo, and im eager to try it out. Probably tonight lol.
And I've also heard that K on the tail end of the plateau of a M roll is supposedly a great buzz too. Maybe be a good combo to be utilized at a 12+ hr festivals , when towards end of the night and just before dawn they usually have the heavy bass dj's spin around that time. So you will be having a mix of best of both worlds, where in the beginning you'd be munted as fuck , just jamming out, but then towards the end you still want to party but don't really know how to jam out to dubstep (which obviously lacks any sort of melody) and don't feel like redosing mandy, then that would be the time to rail some delicious good special k. u wouldn't mind frailing your arms about and headbanging like the rest of those silly bassheads.